The role of prenatal vitamin D on the development of childhood asthma and wheeze: An umbrella review of systematic reviews and meta-analyses

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

The role of prenatal vitamin D on the development of childhood asthma and wheeze : An umbrella review of systematic reviews and meta-analyses. / Thorsteinsdottir, Fanney; Walker, Karen Christina; Runstedt, Suzanne Elizabeth; Jacobsen, Ramune; Maslova, Ekaterina; Backer, Vibeke; Heitmann, Berit Lilienthal; Händel, Mina Nicole.

In: Clinical Nutrition, Vol. 41, No. 8, 2022, p. 1808-1817.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Thorsteinsdottir, F, Walker, KC, Runstedt, SE, Jacobsen, R, Maslova, E, Backer, V, Heitmann, BL & Händel, MN 2022, 'The role of prenatal vitamin D on the development of childhood asthma and wheeze: An umbrella review of systematic reviews and meta-analyses', Clinical Nutrition, vol. 41, no. 8, pp. 1808-1817. https://doi.org/10.1016/j.clnu.2022.06.040

APA

Thorsteinsdottir, F., Walker, K. C., Runstedt, S. E., Jacobsen, R., Maslova, E., Backer, V., Heitmann, B. L., & Händel, M. N. (2022). The role of prenatal vitamin D on the development of childhood asthma and wheeze: An umbrella review of systematic reviews and meta-analyses. Clinical Nutrition, 41(8), 1808-1817. https://doi.org/10.1016/j.clnu.2022.06.040

Vancouver

Thorsteinsdottir F, Walker KC, Runstedt SE, Jacobsen R, Maslova E, Backer V et al. The role of prenatal vitamin D on the development of childhood asthma and wheeze: An umbrella review of systematic reviews and meta-analyses. Clinical Nutrition. 2022;41(8):1808-1817. https://doi.org/10.1016/j.clnu.2022.06.040

Author

Thorsteinsdottir, Fanney ; Walker, Karen Christina ; Runstedt, Suzanne Elizabeth ; Jacobsen, Ramune ; Maslova, Ekaterina ; Backer, Vibeke ; Heitmann, Berit Lilienthal ; Händel, Mina Nicole. / The role of prenatal vitamin D on the development of childhood asthma and wheeze : An umbrella review of systematic reviews and meta-analyses. In: Clinical Nutrition. 2022 ; Vol. 41, No. 8. pp. 1808-1817.

Bibtex

@article{46a0dacd274e4486902bd9ff6a6b9001,
title = "The role of prenatal vitamin D on the development of childhood asthma and wheeze: An umbrella review of systematic reviews and meta-analyses",
abstract = "Background & objective: It has been suggested that prenatal vitamin D plays a role in the development of childhood asthma and wheeze. Several systematic reviews have been conducted, but the results are inconsistent, and the methodological quality has not been studied. Therefore, the objective of this umbrella review was to assess the internal validity of the evidence base and the evidence for an association between prenatal vitamin D and asthma or wheezing in the offspring. Methods: We searched the electronic databases Embase, PubMed, and Cochrane Library for studies on prenatal vitamin D using search words such as vitamin D, 25-hydroxyvitamin D, calcidiol, fetal, and neonatal. The search was conducted in June 2020, and the databases were searched from their date of establishment. We included systematic reviews and/or meta-analyses of experimental and observational studies assessing the association between prenatal vitamin D or asthma and wheeze. We excluded narrative reviews, commentaries, and other umbrella reviews. The methodological quality of systematic reviews was assessed using AMSTAR 2 tool. PROSPERO reg. no. CRD42020151329. Results: We identified 22 eligible systematic reviews (17 on asthma and 20 on wheeze). Using the AMSTAR 2 quality assessment tool, the methodological quality was rated as critically low in 21 out of 22 systematic reviews, suggesting that previous reviews and meta-analyses did not provide accurate and comprehensive summaries of the included studies and that conclusions reached were potentially flawed. The majority of the included reviews reported that prenatal vitamin D reduces the risk of wheeze in the offspring. Conclusion: Prior to informing public guidelines, high-quality systematic reviews of the current evidence are greatly warranted.",
keywords = "25(OH)D, Asthma, Systematic review, Vitamin D, Wheezing",
author = "Fanney Thorsteinsdottir and Walker, {Karen Christina} and Runstedt, {Suzanne Elizabeth} and Ramune Jacobsen and Ekaterina Maslova and Vibeke Backer and Heitmann, {Berit Lilienthal} and H{\"a}ndel, {Mina Nicole}",
note = "Publisher Copyright: {\textcopyright} 2022 The Author(s)",
year = "2022",
doi = "10.1016/j.clnu.2022.06.040",
language = "English",
volume = "41",
pages = "1808--1817",
journal = "Clinical Nutrition",
issn = "0261-5614",
publisher = "Elsevier",
number = "8",

}

RIS

TY - JOUR

T1 - The role of prenatal vitamin D on the development of childhood asthma and wheeze

T2 - An umbrella review of systematic reviews and meta-analyses

AU - Thorsteinsdottir, Fanney

AU - Walker, Karen Christina

AU - Runstedt, Suzanne Elizabeth

AU - Jacobsen, Ramune

AU - Maslova, Ekaterina

AU - Backer, Vibeke

AU - Heitmann, Berit Lilienthal

AU - Händel, Mina Nicole

N1 - Publisher Copyright: © 2022 The Author(s)

PY - 2022

Y1 - 2022

N2 - Background & objective: It has been suggested that prenatal vitamin D plays a role in the development of childhood asthma and wheeze. Several systematic reviews have been conducted, but the results are inconsistent, and the methodological quality has not been studied. Therefore, the objective of this umbrella review was to assess the internal validity of the evidence base and the evidence for an association between prenatal vitamin D and asthma or wheezing in the offspring. Methods: We searched the electronic databases Embase, PubMed, and Cochrane Library for studies on prenatal vitamin D using search words such as vitamin D, 25-hydroxyvitamin D, calcidiol, fetal, and neonatal. The search was conducted in June 2020, and the databases were searched from their date of establishment. We included systematic reviews and/or meta-analyses of experimental and observational studies assessing the association between prenatal vitamin D or asthma and wheeze. We excluded narrative reviews, commentaries, and other umbrella reviews. The methodological quality of systematic reviews was assessed using AMSTAR 2 tool. PROSPERO reg. no. CRD42020151329. Results: We identified 22 eligible systematic reviews (17 on asthma and 20 on wheeze). Using the AMSTAR 2 quality assessment tool, the methodological quality was rated as critically low in 21 out of 22 systematic reviews, suggesting that previous reviews and meta-analyses did not provide accurate and comprehensive summaries of the included studies and that conclusions reached were potentially flawed. The majority of the included reviews reported that prenatal vitamin D reduces the risk of wheeze in the offspring. Conclusion: Prior to informing public guidelines, high-quality systematic reviews of the current evidence are greatly warranted.

AB - Background & objective: It has been suggested that prenatal vitamin D plays a role in the development of childhood asthma and wheeze. Several systematic reviews have been conducted, but the results are inconsistent, and the methodological quality has not been studied. Therefore, the objective of this umbrella review was to assess the internal validity of the evidence base and the evidence for an association between prenatal vitamin D and asthma or wheezing in the offspring. Methods: We searched the electronic databases Embase, PubMed, and Cochrane Library for studies on prenatal vitamin D using search words such as vitamin D, 25-hydroxyvitamin D, calcidiol, fetal, and neonatal. The search was conducted in June 2020, and the databases were searched from their date of establishment. We included systematic reviews and/or meta-analyses of experimental and observational studies assessing the association between prenatal vitamin D or asthma and wheeze. We excluded narrative reviews, commentaries, and other umbrella reviews. The methodological quality of systematic reviews was assessed using AMSTAR 2 tool. PROSPERO reg. no. CRD42020151329. Results: We identified 22 eligible systematic reviews (17 on asthma and 20 on wheeze). Using the AMSTAR 2 quality assessment tool, the methodological quality was rated as critically low in 21 out of 22 systematic reviews, suggesting that previous reviews and meta-analyses did not provide accurate and comprehensive summaries of the included studies and that conclusions reached were potentially flawed. The majority of the included reviews reported that prenatal vitamin D reduces the risk of wheeze in the offspring. Conclusion: Prior to informing public guidelines, high-quality systematic reviews of the current evidence are greatly warranted.

KW - 25(OH)D

KW - Asthma

KW - Systematic review

KW - Vitamin D

KW - Wheezing

U2 - 10.1016/j.clnu.2022.06.040

DO - 10.1016/j.clnu.2022.06.040

M3 - Journal article

C2 - 35834913

AN - SCOPUS:85133920006

VL - 41

SP - 1808

EP - 1817

JO - Clinical Nutrition

JF - Clinical Nutrition

SN - 0261-5614

IS - 8

ER -

ID: 314627017