The potential of human milk oligosaccharides to impact the microbiota-gut-brain axis through modulation of the gut microbiota
Research output: Contribution to journal › Review › Research › peer-review
Standard
The potential of human milk oligosaccharides to impact the microbiota-gut-brain axis through modulation of the gut microbiota. / Al-Khafaji, Alia H.; Jepsen, Stine Dam; Christensen, Kristine Rothaus; Vigsnæs, Louise Kristine.
In: Journal of Functional Foods, Vol. 74, 104176, 2020.Research output: Contribution to journal › Review › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - The potential of human milk oligosaccharides to impact the microbiota-gut-brain axis through modulation of the gut microbiota
AU - Al-Khafaji, Alia H.
AU - Jepsen, Stine Dam
AU - Christensen, Kristine Rothaus
AU - Vigsnæs, Louise Kristine
PY - 2020
Y1 - 2020
N2 - Human milk oligosaccharides (HMOs) are the first prebiotics humans meet in life. HMOs provide many benefits to infants including impact on gut bacteria, promotion of postnatal brain development, and modulation of the immune system. A complex bidirectional communication pathway called the microbiota-gut-brain axis links gut homeostasis and microbial composition with the central nervous system (CNS). Several mechanisms regulated by the gut microbiota are known to affect this axis. Dynamics in microbiota composition changes the metabolite profile in the gut, including neuroactive biomolecules that influence brain function and health. The gut microbiota also has the potential to affect and interact with the neurologic, immunologic and endocrine pathways of the microbiota-gut-brain axis. In this review, we discuss the potential role of HMOs in microbiota-gut-brain axis and CNS disorders, by describing the role of the gut microbiota in relation to brain health and the importance of dietary interventions in manipulating the microbiota-gut-brain axis.
AB - Human milk oligosaccharides (HMOs) are the first prebiotics humans meet in life. HMOs provide many benefits to infants including impact on gut bacteria, promotion of postnatal brain development, and modulation of the immune system. A complex bidirectional communication pathway called the microbiota-gut-brain axis links gut homeostasis and microbial composition with the central nervous system (CNS). Several mechanisms regulated by the gut microbiota are known to affect this axis. Dynamics in microbiota composition changes the metabolite profile in the gut, including neuroactive biomolecules that influence brain function and health. The gut microbiota also has the potential to affect and interact with the neurologic, immunologic and endocrine pathways of the microbiota-gut-brain axis. In this review, we discuss the potential role of HMOs in microbiota-gut-brain axis and CNS disorders, by describing the role of the gut microbiota in relation to brain health and the importance of dietary interventions in manipulating the microbiota-gut-brain axis.
KW - Brain disorders
KW - Human gut
KW - Human milk oligosaccharides
KW - Microbiota
KW - Microbiota-gut-brain axis
KW - Neuroactive molecules
U2 - 10.1016/j.jff.2020.104176
DO - 10.1016/j.jff.2020.104176
M3 - Review
AN - SCOPUS:85091356377
VL - 74
JO - Journal of Functional Foods
JF - Journal of Functional Foods
SN - 1756-4646
M1 - 104176
ER -
ID: 249425626