The glymphatic system: A novel component of fundamental neurobiology
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The glymphatic system : A novel component of fundamental neurobiology. / Hablitz, Lauren M.; Nedergaard, Maiken.
In: Journal of Neuroscience, Vol. 41, No. 37, 2021, p. 7698-7711.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - The glymphatic system
T2 - A novel component of fundamental neurobiology
AU - Hablitz, Lauren M.
AU - Nedergaard, Maiken
N1 - Publisher Copyright: © 2021 the authors
PY - 2021
Y1 - 2021
N2 - Throughout the body, lymphatic fluid movement supports critical functions including clearance of excess fluid and metabolic waste. The glymphatic system is the analog of the lymphatic system in the CNS. As such, the glymphatic system plays a key role in regulating directional interstitial fluid movement, waste clearance, and, potentially, brain immunity. The glymphatic system enables bulk movement of CSF from the subarachnoid space along periarterial spaces, where it mixes with interstitial fluid within the parenchyma before ultimately exiting from the parenchyma via perivenous spaces. This review focuses on important questions about the structure of this system, why the brain needs a fluid transport system, and unexplored aspects of brain fluid transport. We provide evidence that astrocytes and blood vessels determine the shape of the perivascular space, ultimately controlling the movement of perivascular fluid. Glymphatic fluid movement has the potential to alter local as well as global transport of signaling molecules and metabolites. We also highlight the evidence for cross talk among the glymphatic system, cardiovascular system, gastrointestinal tract, and lymphatic system. Much remains to be studied, but we propose that the glymphatic/lymphatic system acts as a cornerstone in signaling between the brain and body.
AB - Throughout the body, lymphatic fluid movement supports critical functions including clearance of excess fluid and metabolic waste. The glymphatic system is the analog of the lymphatic system in the CNS. As such, the glymphatic system plays a key role in regulating directional interstitial fluid movement, waste clearance, and, potentially, brain immunity. The glymphatic system enables bulk movement of CSF from the subarachnoid space along periarterial spaces, where it mixes with interstitial fluid within the parenchyma before ultimately exiting from the parenchyma via perivenous spaces. This review focuses on important questions about the structure of this system, why the brain needs a fluid transport system, and unexplored aspects of brain fluid transport. We provide evidence that astrocytes and blood vessels determine the shape of the perivascular space, ultimately controlling the movement of perivascular fluid. Glymphatic fluid movement has the potential to alter local as well as global transport of signaling molecules and metabolites. We also highlight the evidence for cross talk among the glymphatic system, cardiovascular system, gastrointestinal tract, and lymphatic system. Much remains to be studied, but we propose that the glymphatic/lymphatic system acts as a cornerstone in signaling between the brain and body.
KW - Astrocyte
KW - Cerebrospinal fluid
KW - Choroid plexus
KW - Glymphatic
KW - Peptides
KW - Perivascular space
U2 - 10.1523/JNEUROSCI.0619-21.2021
DO - 10.1523/JNEUROSCI.0619-21.2021
M3 - Review
C2 - 34526407
AN - SCOPUS:85115288297
VL - 41
SP - 7698
EP - 7711
JO - The Journal of neuroscience : the official journal of the Society for Neuroscience
JF - The Journal of neuroscience : the official journal of the Society for Neuroscience
SN - 0270-6474
IS - 37
ER -
ID: 286927469