The association between null mutations in the filaggrin gene and contact sensitization to nickel and other chemicals in the general population
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The association between null mutations in the filaggrin gene and contact sensitization to nickel and other chemicals in the general population. / Thyssen, J P; Johansen, J D; Linneberg, A; Menné, T; Nielsen, N H; Meldgaard, M; Szecsi, P B; Stender, S; Carlsen, B C; Stender, Steen.
In: British Journal of Dermatology, Vol. 162, No. 6, 01.06.2010, p. 1278-85.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The association between null mutations in the filaggrin gene and contact sensitization to nickel and other chemicals in the general population
AU - Thyssen, J P
AU - Johansen, J D
AU - Linneberg, A
AU - Menné, T
AU - Nielsen, N H
AU - Meldgaard, M
AU - Szecsi, P B
AU - Stender, S
AU - Carlsen, B C
AU - Stender, Steen
N1 - © 2010 The Authors. Journal Compilation © 2010 British Association of Dermatologists.
PY - 2010/6/1
Y1 - 2010/6/1
N2 - It was recently shown that filaggrin gene (FLG) null mutations are positively associated with nickel sensitization. We have hypothesized that histidine-rich filaggrin proteins in the epidermis chelate nickel ions and prevent their skin penetration and exposure to Langerhans cells. Furthermore, we have proposed that the low degree of genetic predisposition to nickel sensitization found by a Danish twin study was explained by a high prevalence of ear piercing among participants resulting in 'bypassing' of the filaggrin proteins.
AB - It was recently shown that filaggrin gene (FLG) null mutations are positively associated with nickel sensitization. We have hypothesized that histidine-rich filaggrin proteins in the epidermis chelate nickel ions and prevent their skin penetration and exposure to Langerhans cells. Furthermore, we have proposed that the low degree of genetic predisposition to nickel sensitization found by a Danish twin study was explained by a high prevalence of ear piercing among participants resulting in 'bypassing' of the filaggrin proteins.
U2 - http://dx.doi.org/10.1111/j.1365-2133.2010.09708.x
DO - http://dx.doi.org/10.1111/j.1365-2133.2010.09708.x
M3 - Journal article
VL - 162
SP - 1278
EP - 1285
JO - British Journal of Dermatology
JF - British Journal of Dermatology
SN - 0007-0963
IS - 6
ER -
ID: 34093853