Standard
Shared heritability and functional enrichment across six solid cancers. / Jiang, Xia; Finucane, Hilary K; Schumacher, Fredrick R; Schmit, Stephanie L; Tyrer, Jonathan P; Han, Younghun; Michailidou, Kyriaki; Lesseur, Corina; Kuchenbaecker, Karoline B; Dennis, Joe; Conti, David V; Casey, Graham; Gaudet, Mia M; Huyghe, Jeroen R; Albanes, Demetrius; Aldrich, Melinda C; Andrew, Angeline S; Andrulis, Irene L; Anton-Culver, Hoda; Antoniou, Antonis C; Antonenkova, Natalia N; Arnold, Susanne M; Aronson, Kristan J; Arun, Banu K; Bandera, Elisa V; Barkardottir, Rosa B; Barnes, Daniel R; Batra, Jyotsna; Beckmann, Matthias W; Benitez, Javier; Benlloch, Sara; Berchuck, Andrew; Berndt, Sonja I; Bickeböller, Heike; Bien, Stephanie A; Blomqvist, Carl; Boccia, Stefania; Bogdanova, Natalia V; Bojesen, Stig E; Bolla, Manjeet K; Brauch, Hiltrud; Brenner, Hermann; Brenton, James D; Brook, Mark N; Brunet, Joan; Brunnström, Hans; Buchanan, Daniel D; Burwinkel, Barbara; Butzow, Ralf; Cadoni, Gabriella; Caldés, Trinidad; Caligo, Maria A; Campbell, Ian; Campbell, Peter T; Cancel-Tassin, Géraldine; Cannon-Albright, Lisa; Campa, Daniele; Caporaso, Neil; Carvalho, André L; Chan, Andrew T; Chang-Claude, Jenny; Chanock, Stephen J; Chen, Chu; Christiani, David C; Claes, Kathleen B M; Claessens, Frank; Clements, Judith; Collée, J Margriet; Correa, Marcia Cruz; Couch, Fergus J; Cox, Angela; Cunningham, Julie M; Cybulski, Cezary; Czene, Kamila; Daly, Mary B; deFazio, Anna; Devilee, Peter; Diez, Orland; Gago-Dominguez, Manuela; Donovan, Jenny L; Dörk, Thilo; Duell, Eric J; Dunning, Alison M; Dwek, Miriam; Eccles, Diana M; Edlund, Christopher K; Edwards, Digna R Velez; Ellberg, Carolina; Evans, D Gareth; Fasching, Peter A; Ferris, Robert L; Liloglou, Triantafillos; Figueiredo, Jane C; Fletcher, Olivia; Fortner, Renée T; Fostira, Florentia; Franceschi, Silvia; Friedman, Eitan; Gallinger, Steven J; Ganz, Patricia A; Garber, Judy; García-Sáenz, José A; Gayther, Simon A; Giles, Graham G; Godwin, Andrew K; Goldberg, Mark S; Goldgar, David E; Goode, Ellen L; Goodman, Marc T; Goodman, Gary; Grankvist, Kjell; Greene, Mark H; Gronberg, Henrik; Gronwald, Jacek; Guénel, Pascal; Håkansson, Niclas; Hall, Per; Hamann, Ute; Hamdy, Freddie C; Hamilton, Robert J; Hampe, Jochen; Haugen, Aage; Heitz, Florian; Herrero, Rolando; Hillemanns, Peter; Hoffmeister, Michael; Høgdall, Estrid; Hong, Yun-Chul; Hopper, John L; Houlston, Richard; Hulick, Peter J; Hunter, David J; Huntsman, David G; Idos, Gregory; Imyanitov, Evgeny N; Ingles, Sue Ann; Isaacs, Claudine; Jakubowska, Anna; James, Paul; Jenkins, Mark A; Johansson, Mattias; Johansson, Mikael; John, Esther M; Joshi, Amit D; Kaneva, Radka; Karlan, Beth Y; Kelemen, Linda E; Kühl, Tabea; Khaw, Kay-Tee; Khusnutdinova, Elza; Kibel, Adam S; Kiemeney, Lambertus A; Kim, Jeri; Kjaer, Susanne K; Knight, Julia A; Kogevinas, Manolis; Kote-Jarai, Zsofia; Koutros, Stella; Kristensen, Vessela N; Kupryjanczyk, Jolanta; Lacko, Martin; Lam, Stephan; Lambrechts, Diether; Landi, Maria Teresa; Lazarus, Philip; Le, Nhu D; Lee, Eunjung; Lejbkowicz, Flavio; Lenz, Heinz-Josef; Leslie, Goska; Lessel, Davor; Lester, Jenny; Levine, Douglas A; Li, Li; Li, Christopher I; Lindblom, Annika; Lindor, Noralane M; Liu, Geoffrey; Loupakis, Fotios; Lubiński, Jan; Maehle, Lovise; Maier, Christiane; Mannermaa, Arto; Marchand, Loic Le; Margolin, Sara; May, Taymaa; McGuffog, Lesley; Meindl, Alfons; Middha, Pooja; Miller, Austin; Milne, Roger L; MacInnis, Robert J; Modugno, Francesmary; Montagna, Marco; Moreno, Victor; Moysich, Kirsten B; Mucci, Lorelei; Muir, Kenneth; Mulligan, Anna Marie; Nathanson, Katherine L; Neal, David E; Ness, Andrew R; Neuhausen, Susan L; Nevanlinna, Heli; Newcomb, Polly A; Newcomb, Lisa F; Nielsen, Finn Cilius; Nikitina-Zake, Liene; Nordestgaard, Børge G; Nussbaum, Robert L; Offit, Kenneth; Olah, Edith; Olama, Ali Amin Al; Olopade, Olufunmilayo I; Olshan, Andrew F; Olsson, Håkan; Osorio, Ana; Pandha, Hardev; Park, Jong Y; Pashayan, Nora; Parsons, Michael T; Pejovic, Tanja; Penney, Kathryn L; Peters, Wilbert H M; Phelan, Catherine M; Phipps, Amanda I; Plaseska-Karanfilska, Dijana; Pring, Miranda; Prokofyeva, Darya; Radice, Paolo; Stefansson, Kari; Ramus, Susan J; Raskin, Leon; Rennert, Gad; Rennert, Hedy S; van Rensburg, Elizabeth J; Riggan, Marjorie J; Risch, Harvey A; Risch, Angela; Roobol, Monique J; Rosenstein, Barry S; Rossing, Mary Anne; De Ruyck, Kim; Saloustros, Emmanouil; Sandler, Dale P; Sawyer, Elinor J; Schabath, Matthew B; Schleutker, Johanna; Schmidt, Marjanka K; Setiawan, V Wendy; Shen, Hongbing; Siegel, Erin M; Sieh, Weiva; Singer, Christian F; Slattery, Martha L; Sorensen, Karina Dalsgaard; Southey, Melissa C; Spurdle, Amanda B; Stanford, Janet L; Stevens, Victoria L; Stintzing, Sebastian; Stone, Jennifer; Sundfeldt, Karin; Sutphen, Rebecca; Swerdlow, Anthony J; Tajara, Eloiza H; Tangen, Catherine M; Tardon, Adonina; Taylor, Jack A; Teare, M Dawn; Teixeira, Manuel R; Terry, Mary Beth; Terry, Kathryn L; Thibodeau, Stephen N; Thomassen, Mads; Bjørge, Line; Tischkowitz, Marc; Toland, Amanda E; Torres, Diana; Townsend, Paul A; Travis, Ruth C; Tung, Nadine; Tworoger, Shelley S; Ulrich, Cornelia M; Usmani, Nawaid; Vachon, Celine M; Van Nieuwenhuysen, Els; Vega, Ana; Aguado-Barrera, Miguel Elías; Wang, Qin; Webb, Penelope M; Weinberg, Clarice R; Weinstein, Stephanie; Weissler, Mark C; Weitzel, Jeffrey N; West, Catharine M L; White, Emily; Whittemore, Alice S; Wichmann, H-Erich; Wiklund, Fredrik; Winqvist, Robert; Wolk, Alicja; Woll, Penella; Woods, Michael; Wu, Anna H; Wu, Xifeng; Yannoukakos, Drakoulis; Zheng, Wei; Zienolddiny, Shanbeh; Ziogas, Argyrios; Zorn, Kristin K; Lane, Jacqueline M; Saxena, Richa; Thomas, Duncan; Hung, Rayjean J; Diergaarde, Brenda; McKay, James; Peters, Ulrike; Hsu, Li; García-Closas, Montserrat; Eeles, Rosalind A; Chenevix-Trench, Georgia; Brennan, Paul J; Haiman, Christopher A; Simard, Jacques; Easton, Douglas F; Gruber, Stephen B; Pharoah, Paul D P; Price, Alkes L; Pasaniuc, Bogdan; Amos, Christopher I; Kraft, Peter; Lindström, Sara.
In:
Nature Communications, Vol. 10, No. 1, 431, 25.01.2019.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Jiang, X, Finucane, HK, Schumacher, FR, Schmit, SL, Tyrer, JP, Han, Y, Michailidou, K, Lesseur, C, Kuchenbaecker, KB, Dennis, J, Conti, DV, Casey, G, Gaudet, MM, Huyghe, JR, Albanes, D, Aldrich, MC, Andrew, AS, Andrulis, IL, Anton-Culver, H, Antoniou, AC, Antonenkova, NN, Arnold, SM, Aronson, KJ, Arun, BK, Bandera, EV, Barkardottir, RB, Barnes, DR, Batra, J, Beckmann, MW, Benitez, J, Benlloch, S, Berchuck, A, Berndt, SI, Bickeböller, H, Bien, SA, Blomqvist, C, Boccia, S, Bogdanova, NV
, Bojesen, SE, Bolla, MK, Brauch, H, Brenner, H, Brenton, JD, Brook, MN, Brunet, J, Brunnström, H, Buchanan, DD, Burwinkel, B, Butzow, R, Cadoni, G, Caldés, T, Caligo, MA, Campbell, I, Campbell, PT, Cancel-Tassin, G, Cannon-Albright, L, Campa, D, Caporaso, N, Carvalho, AL, Chan, AT, Chang-Claude, J, Chanock, SJ, Chen, C, Christiani, DC, Claes, KBM, Claessens, F, Clements, J, Collée, JM, Correa, MC, Couch, FJ, Cox, A, Cunningham, JM, Cybulski, C, Czene, K, Daly, MB, deFazio, A, Devilee, P, Diez, O, Gago-Dominguez, M, Donovan, JL, Dörk, T, Duell, EJ, Dunning, AM, Dwek, M, Eccles, DM, Edlund, CK, Edwards, DRV, Ellberg, C, Evans, DG, Fasching, PA, Ferris, RL, Liloglou, T, Figueiredo, JC, Fletcher, O, Fortner, RT, Fostira, F, Franceschi, S, Friedman, E, Gallinger, SJ, Ganz, PA, Garber, J, García-Sáenz, JA, Gayther, SA, Giles, GG, Godwin, AK, Goldberg, MS, Goldgar, DE, Goode, EL, Goodman, MT, Goodman, G, Grankvist, K, Greene, MH, Gronberg, H, Gronwald, J, Guénel, P, Håkansson, N, Hall, P, Hamann, U, Hamdy, FC, Hamilton, RJ, Hampe, J, Haugen, A, Heitz, F, Herrero, R, Hillemanns, P, Hoffmeister, M
, Høgdall, E, Hong, Y-C, Hopper, JL, Houlston, R, Hulick, PJ, Hunter, DJ, Huntsman, DG, Idos, G, Imyanitov, EN, Ingles, SA, Isaacs, C, Jakubowska, A, James, P, Jenkins, MA, Johansson, M, Johansson, M, John, EM, Joshi, AD, Kaneva, R, Karlan, BY, Kelemen, LE, Kühl, T, Khaw, K-T, Khusnutdinova, E, Kibel, AS, Kiemeney, LA, Kim, J
, Kjaer, SK, Knight, JA, Kogevinas, M, Kote-Jarai, Z, Koutros, S, Kristensen, VN, Kupryjanczyk, J, Lacko, M, Lam, S, Lambrechts, D, Landi, MT, Lazarus, P, Le, ND, Lee, E, Lejbkowicz, F, Lenz, H-J, Leslie, G, Lessel, D, Lester, J, Levine, DA, Li, L, Li, CI, Lindblom, A, Lindor, NM, Liu, G, Loupakis, F, Lubiński, J, Maehle, L, Maier, C, Mannermaa, A, Marchand, LL, Margolin, S, May, T, McGuffog, L, Meindl, A, Middha, P, Miller, A, Milne, RL, MacInnis, RJ, Modugno, F, Montagna, M, Moreno, V, Moysich, KB, Mucci, L, Muir, K, Mulligan, AM, Nathanson, KL, Neal, DE, Ness, AR, Neuhausen, SL, Nevanlinna, H, Newcomb, PA, Newcomb, LF
, Nielsen, FC, Nikitina-Zake, L
, Nordestgaard, BG, Nussbaum, RL, Offit, K, Olah, E, Olama, AAA, Olopade, OI, Olshan, AF, Olsson, H, Osorio, A, Pandha, H, Park, JY, Pashayan, N, Parsons, MT, Pejovic, T, Penney, KL, Peters, WHM, Phelan, CM, Phipps, AI, Plaseska-Karanfilska, D, Pring, M, Prokofyeva, D, Radice, P, Stefansson, K, Ramus, SJ, Raskin, L, Rennert, G, Rennert, HS, van Rensburg, EJ, Riggan, MJ, Risch, HA, Risch, A, Roobol, MJ, Rosenstein, BS, Rossing, MA, De Ruyck, K, Saloustros, E, Sandler, DP, Sawyer, EJ, Schabath, MB, Schleutker, J, Schmidt, MK, Setiawan, VW, Shen, H, Siegel, EM, Sieh, W, Singer, CF, Slattery, ML, Sorensen, KD, Southey, MC, Spurdle, AB, Stanford, JL, Stevens, VL, Stintzing, S, Stone, J, Sundfeldt, K, Sutphen, R, Swerdlow, AJ, Tajara, EH, Tangen, CM, Tardon, A, Taylor, JA, Teare, MD, Teixeira, MR, Terry, MB, Terry, KL, Thibodeau, SN, Thomassen, M, Bjørge, L, Tischkowitz, M, Toland, AE, Torres, D, Townsend, PA, Travis, RC, Tung, N, Tworoger, SS, Ulrich, CM, Usmani, N, Vachon, CM, Van Nieuwenhuysen, E, Vega, A, Aguado-Barrera, ME, Wang, Q, Webb, PM, Weinberg, CR, Weinstein, S, Weissler, MC, Weitzel, JN, West, CML, White, E, Whittemore, AS, Wichmann, H-E, Wiklund, F, Winqvist, R, Wolk, A, Woll, P, Woods, M, Wu, AH, Wu, X, Yannoukakos, D, Zheng, W, Zienolddiny, S, Ziogas, A, Zorn, KK, Lane, JM, Saxena, R, Thomas, D, Hung, RJ, Diergaarde, B, McKay, J, Peters, U, Hsu, L, García-Closas, M, Eeles, RA, Chenevix-Trench, G, Brennan, PJ, Haiman, CA, Simard, J, Easton, DF, Gruber, SB, Pharoah, PDP, Price, AL, Pasaniuc, B, Amos, CI, Kraft, P & Lindström, S 2019, '
Shared heritability and functional enrichment across six solid cancers',
Nature Communications, vol. 10, no. 1, 431.
https://doi.org/10.1038/s41467-018-08054-4APA
Jiang, X., Finucane, H. K., Schumacher, F. R., Schmit, S. L., Tyrer, J. P., Han, Y., Michailidou, K., Lesseur, C., Kuchenbaecker, K. B., Dennis, J., Conti, D. V., Casey, G., Gaudet, M. M., Huyghe, J. R., Albanes, D., Aldrich, M. C., Andrew, A. S., Andrulis, I. L., Anton-Culver, H., ... Lindström, S. (2019).
Shared heritability and functional enrichment across six solid cancers.
Nature Communications,
10(1), [431].
https://doi.org/10.1038/s41467-018-08054-4Vancouver
Jiang X, Finucane HK, Schumacher FR, Schmit SL, Tyrer JP, Han Y et al.
Shared heritability and functional enrichment across six solid cancers.
Nature Communications. 2019 Jan 25;10(1). 431.
https://doi.org/10.1038/s41467-018-08054-4Author
Jiang, Xia ; Finucane, Hilary K ; Schumacher, Fredrick R ; Schmit, Stephanie L ; Tyrer, Jonathan P ; Han, Younghun ; Michailidou, Kyriaki ; Lesseur, Corina ; Kuchenbaecker, Karoline B ; Dennis, Joe ; Conti, David V ; Casey, Graham ; Gaudet, Mia M ; Huyghe, Jeroen R ; Albanes, Demetrius ; Aldrich, Melinda C ; Andrew, Angeline S ; Andrulis, Irene L ; Anton-Culver, Hoda ; Antoniou, Antonis C ; Antonenkova, Natalia N ; Arnold, Susanne M ; Aronson, Kristan J ; Arun, Banu K ; Bandera, Elisa V ; Barkardottir, Rosa B ; Barnes, Daniel R ; Batra, Jyotsna ; Beckmann, Matthias W ; Benitez, Javier ; Benlloch, Sara ; Berchuck, Andrew ; Berndt, Sonja I ; Bickeböller, Heike ; Bien, Stephanie A ; Blomqvist, Carl ; Boccia, Stefania ; Bogdanova, Natalia V ; Bojesen, Stig E ; Bolla, Manjeet K ; Brauch, Hiltrud ; Brenner, Hermann ; Brenton, James D ; Brook, Mark N ; Brunet, Joan ; Brunnström, Hans ; Buchanan, Daniel D ; Burwinkel, Barbara ; Butzow, Ralf ; Cadoni, Gabriella ; Caldés, Trinidad ; Caligo, Maria A ; Campbell, Ian ; Campbell, Peter T ; Cancel-Tassin, Géraldine ; Cannon-Albright, Lisa ; Campa, Daniele ; Caporaso, Neil ; Carvalho, André L ; Chan, Andrew T ; Chang-Claude, Jenny ; Chanock, Stephen J ; Chen, Chu ; Christiani, David C ; Claes, Kathleen B M ; Claessens, Frank ; Clements, Judith ; Collée, J Margriet ; Correa, Marcia Cruz ; Couch, Fergus J ; Cox, Angela ; Cunningham, Julie M ; Cybulski, Cezary ; Czene, Kamila ; Daly, Mary B ; deFazio, Anna ; Devilee, Peter ; Diez, Orland ; Gago-Dominguez, Manuela ; Donovan, Jenny L ; Dörk, Thilo ; Duell, Eric J ; Dunning, Alison M ; Dwek, Miriam ; Eccles, Diana M ; Edlund, Christopher K ; Edwards, Digna R Velez ; Ellberg, Carolina ; Evans, D Gareth ; Fasching, Peter A ; Ferris, Robert L ; Liloglou, Triantafillos ; Figueiredo, Jane C ; Fletcher, Olivia ; Fortner, Renée T ; Fostira, Florentia ; Franceschi, Silvia ; Friedman, Eitan ; Gallinger, Steven J ; Ganz, Patricia A ; Garber, Judy ; García-Sáenz, José A ; Gayther, Simon A ; Giles, Graham G ; Godwin, Andrew K ; Goldberg, Mark S ; Goldgar, David E ; Goode, Ellen L ; Goodman, Marc T ; Goodman, Gary ; Grankvist, Kjell ; Greene, Mark H ; Gronberg, Henrik ; Gronwald, Jacek ; Guénel, Pascal ; Håkansson, Niclas ; Hall, Per ; Hamann, Ute ; Hamdy, Freddie C ; Hamilton, Robert J ; Hampe, Jochen ; Haugen, Aage ; Heitz, Florian ; Herrero, Rolando ; Hillemanns, Peter ; Hoffmeister, Michael ; Høgdall, Estrid ; Hong, Yun-Chul ; Hopper, John L ; Houlston, Richard ; Hulick, Peter J ; Hunter, David J ; Huntsman, David G ; Idos, Gregory ; Imyanitov, Evgeny N ; Ingles, Sue Ann ; Isaacs, Claudine ; Jakubowska, Anna ; James, Paul ; Jenkins, Mark A ; Johansson, Mattias ; Johansson, Mikael ; John, Esther M ; Joshi, Amit D ; Kaneva, Radka ; Karlan, Beth Y ; Kelemen, Linda E ; Kühl, Tabea ; Khaw, Kay-Tee ; Khusnutdinova, Elza ; Kibel, Adam S ; Kiemeney, Lambertus A ; Kim, Jeri ; Kjaer, Susanne K ; Knight, Julia A ; Kogevinas, Manolis ; Kote-Jarai, Zsofia ; Koutros, Stella ; Kristensen, Vessela N ; Kupryjanczyk, Jolanta ; Lacko, Martin ; Lam, Stephan ; Lambrechts, Diether ; Landi, Maria Teresa ; Lazarus, Philip ; Le, Nhu D ; Lee, Eunjung ; Lejbkowicz, Flavio ; Lenz, Heinz-Josef ; Leslie, Goska ; Lessel, Davor ; Lester, Jenny ; Levine, Douglas A ; Li, Li ; Li, Christopher I ; Lindblom, Annika ; Lindor, Noralane M ; Liu, Geoffrey ; Loupakis, Fotios ; Lubiński, Jan ; Maehle, Lovise ; Maier, Christiane ; Mannermaa, Arto ; Marchand, Loic Le ; Margolin, Sara ; May, Taymaa ; McGuffog, Lesley ; Meindl, Alfons ; Middha, Pooja ; Miller, Austin ; Milne, Roger L ; MacInnis, Robert J ; Modugno, Francesmary ; Montagna, Marco ; Moreno, Victor ; Moysich, Kirsten B ; Mucci, Lorelei ; Muir, Kenneth ; Mulligan, Anna Marie ; Nathanson, Katherine L ; Neal, David E ; Ness, Andrew R ; Neuhausen, Susan L ; Nevanlinna, Heli ; Newcomb, Polly A ; Newcomb, Lisa F ; Nielsen, Finn Cilius ; Nikitina-Zake, Liene ; Nordestgaard, Børge G ; Nussbaum, Robert L ; Offit, Kenneth ; Olah, Edith ; Olama, Ali Amin Al ; Olopade, Olufunmilayo I ; Olshan, Andrew F ; Olsson, Håkan ; Osorio, Ana ; Pandha, Hardev ; Park, Jong Y ; Pashayan, Nora ; Parsons, Michael T ; Pejovic, Tanja ; Penney, Kathryn L ; Peters, Wilbert H M ; Phelan, Catherine M ; Phipps, Amanda I ; Plaseska-Karanfilska, Dijana ; Pring, Miranda ; Prokofyeva, Darya ; Radice, Paolo ; Stefansson, Kari ; Ramus, Susan J ; Raskin, Leon ; Rennert, Gad ; Rennert, Hedy S ; van Rensburg, Elizabeth J ; Riggan, Marjorie J ; Risch, Harvey A ; Risch, Angela ; Roobol, Monique J ; Rosenstein, Barry S ; Rossing, Mary Anne ; De Ruyck, Kim ; Saloustros, Emmanouil ; Sandler, Dale P ; Sawyer, Elinor J ; Schabath, Matthew B ; Schleutker, Johanna ; Schmidt, Marjanka K ; Setiawan, V Wendy ; Shen, Hongbing ; Siegel, Erin M ; Sieh, Weiva ; Singer, Christian F ; Slattery, Martha L ; Sorensen, Karina Dalsgaard ; Southey, Melissa C ; Spurdle, Amanda B ; Stanford, Janet L ; Stevens, Victoria L ; Stintzing, Sebastian ; Stone, Jennifer ; Sundfeldt, Karin ; Sutphen, Rebecca ; Swerdlow, Anthony J ; Tajara, Eloiza H ; Tangen, Catherine M ; Tardon, Adonina ; Taylor, Jack A ; Teare, M Dawn ; Teixeira, Manuel R ; Terry, Mary Beth ; Terry, Kathryn L ; Thibodeau, Stephen N ; Thomassen, Mads ; Bjørge, Line ; Tischkowitz, Marc ; Toland, Amanda E ; Torres, Diana ; Townsend, Paul A ; Travis, Ruth C ; Tung, Nadine ; Tworoger, Shelley S ; Ulrich, Cornelia M ; Usmani, Nawaid ; Vachon, Celine M ; Van Nieuwenhuysen, Els ; Vega, Ana ; Aguado-Barrera, Miguel Elías ; Wang, Qin ; Webb, Penelope M ; Weinberg, Clarice R ; Weinstein, Stephanie ; Weissler, Mark C ; Weitzel, Jeffrey N ; West, Catharine M L ; White, Emily ; Whittemore, Alice S ; Wichmann, H-Erich ; Wiklund, Fredrik ; Winqvist, Robert ; Wolk, Alicja ; Woll, Penella ; Woods, Michael ; Wu, Anna H ; Wu, Xifeng ; Yannoukakos, Drakoulis ; Zheng, Wei ; Zienolddiny, Shanbeh ; Ziogas, Argyrios ; Zorn, Kristin K ; Lane, Jacqueline M ; Saxena, Richa ; Thomas, Duncan ; Hung, Rayjean J ; Diergaarde, Brenda ; McKay, James ; Peters, Ulrike ; Hsu, Li ; García-Closas, Montserrat ; Eeles, Rosalind A ; Chenevix-Trench, Georgia ; Brennan, Paul J ; Haiman, Christopher A ; Simard, Jacques ; Easton, Douglas F ; Gruber, Stephen B ; Pharoah, Paul D P ; Price, Alkes L ; Pasaniuc, Bogdan ; Amos, Christopher I ; Kraft, Peter ; Lindström, Sara. / Shared heritability and functional enrichment across six solid cancers. In: Nature Communications. 2019 ; Vol. 10, No. 1.
Bibtex
@article{d761349df14444d084190579c7900588,
title = "Shared heritability and functional enrichment across six solid cancers",
abstract = "Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg = 0.57, p = 4.6 × 10-8), breast and ovarian cancer (rg = 0.24, p = 7 × 10-5), breast and lung cancer (rg = 0.18, p =1.5 × 10-6) and breast and colorectal cancer (rg = 0.15, p = 1.1 × 10-4). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.",
keywords = "Breast Neoplasms/diagnosis, Case-Control Studies, Colorectal Neoplasms/diagnosis, European Continental Ancestry Group, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Head and Neck Neoplasms/diagnosis, Humans, Inheritance Patterns, Lung Neoplasms/diagnosis, Male, Mental Disorders/ethnology, Neoplasm Proteins/genetics, Ovarian Neoplasms/diagnosis, Phenotype, Polymorphism, Single Nucleotide, Prostatic Neoplasms/diagnosis, Smoking/ethnology",
author = "Xia Jiang and Finucane, {Hilary K} and Schumacher, {Fredrick R} and Schmit, {Stephanie L} and Tyrer, {Jonathan P} and Younghun Han and Kyriaki Michailidou and Corina Lesseur and Kuchenbaecker, {Karoline B} and Joe Dennis and Conti, {David V} and Graham Casey and Gaudet, {Mia M} and Huyghe, {Jeroen R} and Demetrius Albanes and Aldrich, {Melinda C} and Andrew, {Angeline S} and Andrulis, {Irene L} and Hoda Anton-Culver and Antoniou, {Antonis C} and Antonenkova, {Natalia N} and Arnold, {Susanne M} and Aronson, {Kristan J} and Arun, {Banu K} and Bandera, {Elisa V} and Barkardottir, {Rosa B} and Barnes, {Daniel R} and Jyotsna Batra and Beckmann, {Matthias W} and Javier Benitez and Sara Benlloch and Andrew Berchuck and Berndt, {Sonja I} and Heike Bickeb{\"o}ller and Bien, {Stephanie A} and Carl Blomqvist and Stefania Boccia and Bogdanova, {Natalia V} and Bojesen, {Stig E} and Bolla, {Manjeet K} and Hiltrud Brauch and Hermann Brenner and Brenton, {James D} and Brook, {Mark N} and Joan Brunet and Hans Brunnstr{\"o}m and Buchanan, {Daniel D} and Barbara Burwinkel and Ralf Butzow and Gabriella Cadoni and Trinidad Cald{\'e}s and Caligo, {Maria A} and Ian Campbell and Campbell, {Peter T} and G{\'e}raldine Cancel-Tassin and Lisa Cannon-Albright and Daniele Campa and Neil Caporaso and Carvalho, {Andr{\'e} L} and Chan, {Andrew T} and Jenny Chang-Claude and Chanock, {Stephen J} and Chu Chen and Christiani, {David C} and Claes, {Kathleen B M} and Frank Claessens and Judith Clements and Coll{\'e}e, {J Margriet} and Correa, {Marcia Cruz} and Couch, {Fergus J} and Angela Cox and Cunningham, {Julie M} and Cezary Cybulski and Kamila Czene and Daly, {Mary B} and Anna deFazio and Peter Devilee and Orland Diez and Manuela Gago-Dominguez and Donovan, {Jenny L} and Thilo D{\"o}rk and Duell, {Eric J} and Dunning, {Alison M} and Miriam Dwek and Eccles, {Diana M} and Edlund, {Christopher K} and Edwards, {Digna R Velez} and Carolina Ellberg and Evans, {D Gareth} and Fasching, {Peter A} and Ferris, {Robert L} and Triantafillos Liloglou and Figueiredo, {Jane C} and Olivia Fletcher and Fortner, {Ren{\'e}e T} and Florentia Fostira and Silvia Franceschi and Eitan Friedman and Gallinger, {Steven J} and Ganz, {Patricia A} and Judy Garber and Garc{\'i}a-S{\'a}enz, {Jos{\'e} A} and Gayther, {Simon A} and Giles, {Graham G} and Godwin, {Andrew K} and Goldberg, {Mark S} and Goldgar, {David E} and Goode, {Ellen L} and Goodman, {Marc T} and Gary Goodman and Kjell Grankvist and Greene, {Mark H} and Henrik Gronberg and Jacek Gronwald and Pascal Gu{\'e}nel and Niclas H{\aa}kansson and Per Hall and Ute Hamann and Hamdy, {Freddie C} and Hamilton, {Robert J} and Jochen Hampe and Aage Haugen and Florian Heitz and Rolando Herrero and Peter Hillemanns and Michael Hoffmeister and Estrid H{\o}gdall and Yun-Chul Hong and Hopper, {John L} and Richard Houlston and Hulick, {Peter J} and Hunter, {David J} and Huntsman, {David G} and Gregory Idos and Imyanitov, {Evgeny N} and Ingles, {Sue Ann} and Claudine Isaacs and Anna Jakubowska and Paul James and Jenkins, {Mark A} and Mattias Johansson and Mikael Johansson and John, {Esther M} and Joshi, {Amit D} and Radka Kaneva and Karlan, {Beth Y} and Kelemen, {Linda E} and Tabea K{\"u}hl and Kay-Tee Khaw and Elza Khusnutdinova and Kibel, {Adam S} and Kiemeney, {Lambertus A} and Jeri Kim and Kjaer, {Susanne K} and Knight, {Julia A} and Manolis Kogevinas and Zsofia Kote-Jarai and Stella Koutros and Kristensen, {Vessela N} and Jolanta Kupryjanczyk and Martin Lacko and Stephan Lam and Diether Lambrechts and Landi, {Maria Teresa} and Philip Lazarus and Le, {Nhu D} and Eunjung Lee and Flavio Lejbkowicz and Heinz-Josef Lenz and Goska Leslie and Davor Lessel and Jenny Lester and Levine, {Douglas A} and Li Li and Li, {Christopher I} and Annika Lindblom and Lindor, {Noralane M} and Geoffrey Liu and Fotios Loupakis and Jan Lubi{\'n}ski and Lovise Maehle and Christiane Maier and Arto Mannermaa and Marchand, {Loic Le} and Sara Margolin and Taymaa May and Lesley McGuffog and Alfons Meindl and Pooja Middha and Austin Miller and Milne, {Roger L} and MacInnis, {Robert J} and Francesmary Modugno and Marco Montagna and Victor Moreno and Moysich, {Kirsten B} and Lorelei Mucci and Kenneth Muir and Mulligan, {Anna Marie} and Nathanson, {Katherine L} and Neal, {David E} and Ness, {Andrew R} and Neuhausen, {Susan L} and Heli Nevanlinna and Newcomb, {Polly A} and Newcomb, {Lisa F} and Nielsen, {Finn Cilius} and Liene Nikitina-Zake and Nordestgaard, {B{\o}rge G} and Nussbaum, {Robert L} and Kenneth Offit and Edith Olah and Olama, {Ali Amin Al} and Olopade, {Olufunmilayo I} and Olshan, {Andrew F} and H{\aa}kan Olsson and Ana Osorio and Hardev Pandha and Park, {Jong Y} and Nora Pashayan and Parsons, {Michael T} and Tanja Pejovic and Penney, {Kathryn L} and Peters, {Wilbert H M} and Phelan, {Catherine M} and Phipps, {Amanda I} and Dijana Plaseska-Karanfilska and Miranda Pring and Darya Prokofyeva and Paolo Radice and Kari Stefansson and Ramus, {Susan J} and Leon Raskin and Gad Rennert and Rennert, {Hedy S} and {van Rensburg}, {Elizabeth J} and Riggan, {Marjorie J} and Risch, {Harvey A} and Angela Risch and Roobol, {Monique J} and Rosenstein, {Barry S} and Rossing, {Mary Anne} and {De Ruyck}, Kim and Emmanouil Saloustros and Sandler, {Dale P} and Sawyer, {Elinor J} and Schabath, {Matthew B} and Johanna Schleutker and Schmidt, {Marjanka K} and Setiawan, {V Wendy} and Hongbing Shen and Siegel, {Erin M} and Weiva Sieh and Singer, {Christian F} and Slattery, {Martha L} and Sorensen, {Karina Dalsgaard} and Southey, {Melissa C} and Spurdle, {Amanda B} and Stanford, {Janet L} and Stevens, {Victoria L} and Sebastian Stintzing and Jennifer Stone and Karin Sundfeldt and Rebecca Sutphen and Swerdlow, {Anthony J} and Tajara, {Eloiza H} and Tangen, {Catherine M} and Adonina Tardon and Taylor, {Jack A} and Teare, {M Dawn} and Teixeira, {Manuel R} and Terry, {Mary Beth} and Terry, {Kathryn L} and Thibodeau, {Stephen N} and Mads Thomassen and Line Bj{\o}rge and Marc Tischkowitz and Toland, {Amanda E} and Diana Torres and Townsend, {Paul A} and Travis, {Ruth C} and Nadine Tung and Tworoger, {Shelley S} and Ulrich, {Cornelia M} and Nawaid Usmani and Vachon, {Celine M} and {Van Nieuwenhuysen}, Els and Ana Vega and Aguado-Barrera, {Miguel El{\'i}as} and Qin Wang and Webb, {Penelope M} and Weinberg, {Clarice R} and Stephanie Weinstein and Weissler, {Mark C} and Weitzel, {Jeffrey N} and West, {Catharine M L} and Emily White and Whittemore, {Alice S} and H-Erich Wichmann and Fredrik Wiklund and Robert Winqvist and Alicja Wolk and Penella Woll and Michael Woods and Wu, {Anna H} and Xifeng Wu and Drakoulis Yannoukakos and Wei Zheng and Shanbeh Zienolddiny and Argyrios Ziogas and Zorn, {Kristin K} and Lane, {Jacqueline M} and Richa Saxena and Duncan Thomas and Hung, {Rayjean J} and Brenda Diergaarde and James McKay and Ulrike Peters and Li Hsu and Montserrat Garc{\'i}a-Closas and Eeles, {Rosalind A} and Georgia Chenevix-Trench and Brennan, {Paul J} and Haiman, {Christopher A} and Jacques Simard and Easton, {Douglas F} and Gruber, {Stephen B} and Pharoah, {Paul D P} and Price, {Alkes L} and Bogdan Pasaniuc and Amos, {Christopher I} and Peter Kraft and Sara Lindstr{\"o}m",
year = "2019",
month = jan,
day = "25",
doi = "10.1038/s41467-018-08054-4",
language = "English",
volume = "10",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",
number = "1",
}
RIS
TY - JOUR
T1 - Shared heritability and functional enrichment across six solid cancers
AU - Jiang, Xia
AU - Finucane, Hilary K
AU - Schumacher, Fredrick R
AU - Schmit, Stephanie L
AU - Tyrer, Jonathan P
AU - Han, Younghun
AU - Michailidou, Kyriaki
AU - Lesseur, Corina
AU - Kuchenbaecker, Karoline B
AU - Dennis, Joe
AU - Conti, David V
AU - Casey, Graham
AU - Gaudet, Mia M
AU - Huyghe, Jeroen R
AU - Albanes, Demetrius
AU - Aldrich, Melinda C
AU - Andrew, Angeline S
AU - Andrulis, Irene L
AU - Anton-Culver, Hoda
AU - Antoniou, Antonis C
AU - Antonenkova, Natalia N
AU - Arnold, Susanne M
AU - Aronson, Kristan J
AU - Arun, Banu K
AU - Bandera, Elisa V
AU - Barkardottir, Rosa B
AU - Barnes, Daniel R
AU - Batra, Jyotsna
AU - Beckmann, Matthias W
AU - Benitez, Javier
AU - Benlloch, Sara
AU - Berchuck, Andrew
AU - Berndt, Sonja I
AU - Bickeböller, Heike
AU - Bien, Stephanie A
AU - Blomqvist, Carl
AU - Boccia, Stefania
AU - Bogdanova, Natalia V
AU - Bojesen, Stig E
AU - Bolla, Manjeet K
AU - Brauch, Hiltrud
AU - Brenner, Hermann
AU - Brenton, James D
AU - Brook, Mark N
AU - Brunet, Joan
AU - Brunnström, Hans
AU - Buchanan, Daniel D
AU - Burwinkel, Barbara
AU - Butzow, Ralf
AU - Cadoni, Gabriella
AU - Caldés, Trinidad
AU - Caligo, Maria A
AU - Campbell, Ian
AU - Campbell, Peter T
AU - Cancel-Tassin, Géraldine
AU - Cannon-Albright, Lisa
AU - Campa, Daniele
AU - Caporaso, Neil
AU - Carvalho, André L
AU - Chan, Andrew T
AU - Chang-Claude, Jenny
AU - Chanock, Stephen J
AU - Chen, Chu
AU - Christiani, David C
AU - Claes, Kathleen B M
AU - Claessens, Frank
AU - Clements, Judith
AU - Collée, J Margriet
AU - Correa, Marcia Cruz
AU - Couch, Fergus J
AU - Cox, Angela
AU - Cunningham, Julie M
AU - Cybulski, Cezary
AU - Czene, Kamila
AU - Daly, Mary B
AU - deFazio, Anna
AU - Devilee, Peter
AU - Diez, Orland
AU - Gago-Dominguez, Manuela
AU - Donovan, Jenny L
AU - Dörk, Thilo
AU - Duell, Eric J
AU - Dunning, Alison M
AU - Dwek, Miriam
AU - Eccles, Diana M
AU - Edlund, Christopher K
AU - Edwards, Digna R Velez
AU - Ellberg, Carolina
AU - Evans, D Gareth
AU - Fasching, Peter A
AU - Ferris, Robert L
AU - Liloglou, Triantafillos
AU - Figueiredo, Jane C
AU - Fletcher, Olivia
AU - Fortner, Renée T
AU - Fostira, Florentia
AU - Franceschi, Silvia
AU - Friedman, Eitan
AU - Gallinger, Steven J
AU - Ganz, Patricia A
AU - Garber, Judy
AU - García-Sáenz, José A
AU - Gayther, Simon A
AU - Giles, Graham G
AU - Godwin, Andrew K
AU - Goldberg, Mark S
AU - Goldgar, David E
AU - Goode, Ellen L
AU - Goodman, Marc T
AU - Goodman, Gary
AU - Grankvist, Kjell
AU - Greene, Mark H
AU - Gronberg, Henrik
AU - Gronwald, Jacek
AU - Guénel, Pascal
AU - Håkansson, Niclas
AU - Hall, Per
AU - Hamann, Ute
AU - Hamdy, Freddie C
AU - Hamilton, Robert J
AU - Hampe, Jochen
AU - Haugen, Aage
AU - Heitz, Florian
AU - Herrero, Rolando
AU - Hillemanns, Peter
AU - Hoffmeister, Michael
AU - Høgdall, Estrid
AU - Hong, Yun-Chul
AU - Hopper, John L
AU - Houlston, Richard
AU - Hulick, Peter J
AU - Hunter, David J
AU - Huntsman, David G
AU - Idos, Gregory
AU - Imyanitov, Evgeny N
AU - Ingles, Sue Ann
AU - Isaacs, Claudine
AU - Jakubowska, Anna
AU - James, Paul
AU - Jenkins, Mark A
AU - Johansson, Mattias
AU - Johansson, Mikael
AU - John, Esther M
AU - Joshi, Amit D
AU - Kaneva, Radka
AU - Karlan, Beth Y
AU - Kelemen, Linda E
AU - Kühl, Tabea
AU - Khaw, Kay-Tee
AU - Khusnutdinova, Elza
AU - Kibel, Adam S
AU - Kiemeney, Lambertus A
AU - Kim, Jeri
AU - Kjaer, Susanne K
AU - Knight, Julia A
AU - Kogevinas, Manolis
AU - Kote-Jarai, Zsofia
AU - Koutros, Stella
AU - Kristensen, Vessela N
AU - Kupryjanczyk, Jolanta
AU - Lacko, Martin
AU - Lam, Stephan
AU - Lambrechts, Diether
AU - Landi, Maria Teresa
AU - Lazarus, Philip
AU - Le, Nhu D
AU - Lee, Eunjung
AU - Lejbkowicz, Flavio
AU - Lenz, Heinz-Josef
AU - Leslie, Goska
AU - Lessel, Davor
AU - Lester, Jenny
AU - Levine, Douglas A
AU - Li, Li
AU - Li, Christopher I
AU - Lindblom, Annika
AU - Lindor, Noralane M
AU - Liu, Geoffrey
AU - Loupakis, Fotios
AU - Lubiński, Jan
AU - Maehle, Lovise
AU - Maier, Christiane
AU - Mannermaa, Arto
AU - Marchand, Loic Le
AU - Margolin, Sara
AU - May, Taymaa
AU - McGuffog, Lesley
AU - Meindl, Alfons
AU - Middha, Pooja
AU - Miller, Austin
AU - Milne, Roger L
AU - MacInnis, Robert J
AU - Modugno, Francesmary
AU - Montagna, Marco
AU - Moreno, Victor
AU - Moysich, Kirsten B
AU - Mucci, Lorelei
AU - Muir, Kenneth
AU - Mulligan, Anna Marie
AU - Nathanson, Katherine L
AU - Neal, David E
AU - Ness, Andrew R
AU - Neuhausen, Susan L
AU - Nevanlinna, Heli
AU - Newcomb, Polly A
AU - Newcomb, Lisa F
AU - Nielsen, Finn Cilius
AU - Nikitina-Zake, Liene
AU - Nordestgaard, Børge G
AU - Nussbaum, Robert L
AU - Offit, Kenneth
AU - Olah, Edith
AU - Olama, Ali Amin Al
AU - Olopade, Olufunmilayo I
AU - Olshan, Andrew F
AU - Olsson, Håkan
AU - Osorio, Ana
AU - Pandha, Hardev
AU - Park, Jong Y
AU - Pashayan, Nora
AU - Parsons, Michael T
AU - Pejovic, Tanja
AU - Penney, Kathryn L
AU - Peters, Wilbert H M
AU - Phelan, Catherine M
AU - Phipps, Amanda I
AU - Plaseska-Karanfilska, Dijana
AU - Pring, Miranda
AU - Prokofyeva, Darya
AU - Radice, Paolo
AU - Stefansson, Kari
AU - Ramus, Susan J
AU - Raskin, Leon
AU - Rennert, Gad
AU - Rennert, Hedy S
AU - van Rensburg, Elizabeth J
AU - Riggan, Marjorie J
AU - Risch, Harvey A
AU - Risch, Angela
AU - Roobol, Monique J
AU - Rosenstein, Barry S
AU - Rossing, Mary Anne
AU - De Ruyck, Kim
AU - Saloustros, Emmanouil
AU - Sandler, Dale P
AU - Sawyer, Elinor J
AU - Schabath, Matthew B
AU - Schleutker, Johanna
AU - Schmidt, Marjanka K
AU - Setiawan, V Wendy
AU - Shen, Hongbing
AU - Siegel, Erin M
AU - Sieh, Weiva
AU - Singer, Christian F
AU - Slattery, Martha L
AU - Sorensen, Karina Dalsgaard
AU - Southey, Melissa C
AU - Spurdle, Amanda B
AU - Stanford, Janet L
AU - Stevens, Victoria L
AU - Stintzing, Sebastian
AU - Stone, Jennifer
AU - Sundfeldt, Karin
AU - Sutphen, Rebecca
AU - Swerdlow, Anthony J
AU - Tajara, Eloiza H
AU - Tangen, Catherine M
AU - Tardon, Adonina
AU - Taylor, Jack A
AU - Teare, M Dawn
AU - Teixeira, Manuel R
AU - Terry, Mary Beth
AU - Terry, Kathryn L
AU - Thibodeau, Stephen N
AU - Thomassen, Mads
AU - Bjørge, Line
AU - Tischkowitz, Marc
AU - Toland, Amanda E
AU - Torres, Diana
AU - Townsend, Paul A
AU - Travis, Ruth C
AU - Tung, Nadine
AU - Tworoger, Shelley S
AU - Ulrich, Cornelia M
AU - Usmani, Nawaid
AU - Vachon, Celine M
AU - Van Nieuwenhuysen, Els
AU - Vega, Ana
AU - Aguado-Barrera, Miguel Elías
AU - Wang, Qin
AU - Webb, Penelope M
AU - Weinberg, Clarice R
AU - Weinstein, Stephanie
AU - Weissler, Mark C
AU - Weitzel, Jeffrey N
AU - West, Catharine M L
AU - White, Emily
AU - Whittemore, Alice S
AU - Wichmann, H-Erich
AU - Wiklund, Fredrik
AU - Winqvist, Robert
AU - Wolk, Alicja
AU - Woll, Penella
AU - Woods, Michael
AU - Wu, Anna H
AU - Wu, Xifeng
AU - Yannoukakos, Drakoulis
AU - Zheng, Wei
AU - Zienolddiny, Shanbeh
AU - Ziogas, Argyrios
AU - Zorn, Kristin K
AU - Lane, Jacqueline M
AU - Saxena, Richa
AU - Thomas, Duncan
AU - Hung, Rayjean J
AU - Diergaarde, Brenda
AU - McKay, James
AU - Peters, Ulrike
AU - Hsu, Li
AU - García-Closas, Montserrat
AU - Eeles, Rosalind A
AU - Chenevix-Trench, Georgia
AU - Brennan, Paul J
AU - Haiman, Christopher A
AU - Simard, Jacques
AU - Easton, Douglas F
AU - Gruber, Stephen B
AU - Pharoah, Paul D P
AU - Price, Alkes L
AU - Pasaniuc, Bogdan
AU - Amos, Christopher I
AU - Kraft, Peter
AU - Lindström, Sara
PY - 2019/1/25
Y1 - 2019/1/25
N2 - Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg = 0.57, p = 4.6 × 10-8), breast and ovarian cancer (rg = 0.24, p = 7 × 10-5), breast and lung cancer (rg = 0.18, p =1.5 × 10-6) and breast and colorectal cancer (rg = 0.15, p = 1.1 × 10-4). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.
AB - Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg = 0.57, p = 4.6 × 10-8), breast and ovarian cancer (rg = 0.24, p = 7 × 10-5), breast and lung cancer (rg = 0.18, p =1.5 × 10-6) and breast and colorectal cancer (rg = 0.15, p = 1.1 × 10-4). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.
KW - Breast Neoplasms/diagnosis
KW - Case-Control Studies
KW - Colorectal Neoplasms/diagnosis
KW - European Continental Ancestry Group
KW - Female
KW - Genetic Predisposition to Disease
KW - Genome-Wide Association Study
KW - Head and Neck Neoplasms/diagnosis
KW - Humans
KW - Inheritance Patterns
KW - Lung Neoplasms/diagnosis
KW - Male
KW - Mental Disorders/ethnology
KW - Neoplasm Proteins/genetics
KW - Ovarian Neoplasms/diagnosis
KW - Phenotype
KW - Polymorphism, Single Nucleotide
KW - Prostatic Neoplasms/diagnosis
KW - Smoking/ethnology
UR - https://www.nature.com/articles/s41467-019-12095-8
U2 - 10.1038/s41467-018-08054-4
DO - 10.1038/s41467-018-08054-4
M3 - Journal article
C2 - 30683880
VL - 10
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
IS - 1
M1 - 431
ER -
