Role of astrocytes in rhythmic motor activity
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Role of astrocytes in rhythmic motor activity. / Montalant, Alexia; Carlsen, Eva M. M.; Perrier, Jean-Francois.
In: Physiological Reports, Vol. 9, No. 18, 15029, 2021.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Role of astrocytes in rhythmic motor activity
AU - Montalant, Alexia
AU - Carlsen, Eva M. M.
AU - Perrier, Jean-Francois
PY - 2021
Y1 - 2021
N2 - Rhythmic motor activities such as breathing, locomotion, tremor, or mastication are organized by groups of interconnected neurons. Most synapses in the central nervous system are in close apposition with processes belonging to astrocytes. Neurotransmitters released from neurons bind to receptors expressed by astrocytes, activating a signaling pathway that leads to an increase in calcium concentration and the release of gliotransmitters that eventually modulate synaptic transmission. It is therefore likely that the activation of astrocytes impacts motor control. Here we review recent studies demonstrating that astrocytes inhibit, modulate, or trigger motor rhythmic behaviors.
AB - Rhythmic motor activities such as breathing, locomotion, tremor, or mastication are organized by groups of interconnected neurons. Most synapses in the central nervous system are in close apposition with processes belonging to astrocytes. Neurotransmitters released from neurons bind to receptors expressed by astrocytes, activating a signaling pathway that leads to an increase in calcium concentration and the release of gliotransmitters that eventually modulate synaptic transmission. It is therefore likely that the activation of astrocytes impacts motor control. Here we review recent studies demonstrating that astrocytes inhibit, modulate, or trigger motor rhythmic behaviors.
KW - RETROTRAPEZOID NUCLEUS
KW - LOCOMOTOR-ACTIVITY
KW - CENTRAL PATTERN
KW - SPINAL-CORD
KW - ADENOSINE
KW - SENSITIVITY
KW - NETWORKS
KW - CAFFEINE
KW - NEURONS
KW - CHEMORECEPTION
U2 - 10.14814/phy2.15029
DO - 10.14814/phy2.15029
M3 - Review
C2 - 34558208
VL - 9
JO - Physiological Reports
JF - Physiological Reports
SN - 2051-817X
IS - 18
M1 - 15029
ER -
ID: 281095985