Physiology of Astroglia
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Physiology of Astroglia. / Verkhratsky, Alexei; Parpura, Vladimir; Vardjan, Nina; Zorec, Robert.
Neuroglia in Neurodegenerative Diseases. ed. / Alexei Verkhratsky; Margaret S. Ho; Robert Zorec; Vladimir Parpura. Springer, 2019. p. 45-91 (Advances in Experimental Medicine and Biology, Vol. 1175).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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TY - CHAP
T1 - Physiology of Astroglia
AU - Verkhratsky, Alexei
AU - Parpura, Vladimir
AU - Vardjan, Nina
AU - Zorec, Robert
PY - 2019
Y1 - 2019
N2 - Astrocytes are principal cells responsible for maintaining the brain homeostasis. Additionally, these glial cells are also involved in homocellular (astrocyte-astrocyte) and heterocellular (astrocyte-other cell types) signalling and metabolism. These astroglial functions require an expression of the assortment of molecules, be that transporters or pumps, to maintain ion concentration gradients across the plasmalemma and the membrane of the endoplasmic reticulum. Astrocytes sense and balance their neurochemical environment via variety of transmitter receptors and transporters. As they are electrically non-excitable, astrocytes display intracellular calcium and sodium fluctuations, which are not only used for operative signalling but can also affect metabolism. In this chapter we discuss the molecules that achieve ionic gradients and underlie astrocyte signalling.
AB - Astrocytes are principal cells responsible for maintaining the brain homeostasis. Additionally, these glial cells are also involved in homocellular (astrocyte-astrocyte) and heterocellular (astrocyte-other cell types) signalling and metabolism. These astroglial functions require an expression of the assortment of molecules, be that transporters or pumps, to maintain ion concentration gradients across the plasmalemma and the membrane of the endoplasmic reticulum. Astrocytes sense and balance their neurochemical environment via variety of transmitter receptors and transporters. As they are electrically non-excitable, astrocytes display intracellular calcium and sodium fluctuations, which are not only used for operative signalling but can also affect metabolism. In this chapter we discuss the molecules that achieve ionic gradients and underlie astrocyte signalling.
KW - Astrocytes
KW - Brain homoeostasis
KW - Ca signalling
KW - Ion channels
KW - Na signalling
KW - Neurotransmitter receptors
KW - SLC transporters
U2 - 10.1007/978-981-13-9913-8_3
DO - 10.1007/978-981-13-9913-8_3
M3 - Book chapter
C2 - 31583584
AN - SCOPUS:85072916918
SN - 978-981-13-9912-1
T3 - Advances in Experimental Medicine and Biology
SP - 45
EP - 91
BT - Neuroglia in Neurodegenerative Diseases
A2 - Verkhratsky, Alexei
A2 - Ho, Margaret S.
A2 - Zorec, Robert
A2 - Parpura, Vladimir
PB - Springer
ER -
ID: 231243566