Pharmacokinetics/Pharmacodynamics of Colistin and Imipenem on Mucoid and Nonmucoid Pseudomonas aeruginosa Biofilms
Research output: Contribution to journal › Journal article › Research › peer-review
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Pharmacokinetics/Pharmacodynamics of Colistin and Imipenem on Mucoid and Nonmucoid Pseudomonas aeruginosa Biofilms. / Hengzhuang, Wang; Wu, Hong; Ciofu, Oana; Song, Zhijun; Høiby, Niels.
In: Antimicrobial Agents and Chemotherapy, Vol. 55, No. 9, 01.09.2011, p. 4469-74.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Pharmacokinetics/Pharmacodynamics of Colistin and Imipenem on Mucoid and Nonmucoid Pseudomonas aeruginosa Biofilms
AU - Hengzhuang, Wang
AU - Wu, Hong
AU - Ciofu, Oana
AU - Song, Zhijun
AU - Høiby, Niels
PY - 2011/9/1
Y1 - 2011/9/1
N2 - The time course activity of Colistin and Imipenem on mucoid and non-mucoid biofilm-growing P. aeruginosa showed that compared with planktonic bacteria, the kinetics of Colistin and Imipenem retained the concentration- and time-dependent killings, respectively but higher doses of antibiotics and for longer periods were required for biofilm eradication. Biofilms of mucoid P. aeruginosa were more difficult to eradicate compared to non-mucoid biofilms.
AB - The time course activity of Colistin and Imipenem on mucoid and non-mucoid biofilm-growing P. aeruginosa showed that compared with planktonic bacteria, the kinetics of Colistin and Imipenem retained the concentration- and time-dependent killings, respectively but higher doses of antibiotics and for longer periods were required for biofilm eradication. Biofilms of mucoid P. aeruginosa were more difficult to eradicate compared to non-mucoid biofilms.
U2 - 10.1128/AAC.00126-11
DO - 10.1128/AAC.00126-11
M3 - Journal article
C2 - 21670181
VL - 55
SP - 4469
EP - 4474
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 9
ER -
ID: 33842494