Optimising Controlled Human Malaria Infection Studies Using Cryopreserved P. falciparum Parasites Administered by Needle and Syringe
Research output: Contribution to journal › Journal article › Research › peer-review
Controlled human malaria infection (CHMI) studies have become a routine tool to evaluate efficacy of candidate anti-malarial drugs and vaccines. To date, CHMI trials have mostly been conducted using the bite of infected mosquitoes, restricting the number of trial sites that can perform CHMI studies. Aseptic, cryopreserved P. falciparum sporozoites (PfSPZ Challenge) provide a potentially more accurate, reproducible and practical alternative, allowing a known number of sporozoites to be administered simply by injection.
Original language | English |
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Journal | PLOS ONE |
Volume | 8 |
Issue number | 6 |
Pages (from-to) | e65960 |
ISSN | 1932-6203 |
DOIs | |
Publication status | Published - 2013 |
Externally published | Yes |
ID: 47234223