Modulation of blood pressure in response to low ambient temperature: The role of DNA methylation of zinc finger genes
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Modulation of blood pressure in response to low ambient temperature : The role of DNA methylation of zinc finger genes. / Lim, Youn-Hee; Han, Changwoo; Bae, Sanghyuk; Hong, Yun-Chul.
In: Environmental Research, Vol. 153, 2017, p. 106-111.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Modulation of blood pressure in response to low ambient temperature
T2 - The role of DNA methylation of zinc finger genes
AU - Lim, Youn-Hee
AU - Han, Changwoo
AU - Bae, Sanghyuk
AU - Hong, Yun-Chul
N1 - Copyright © 2016 Elsevier Inc. All rights reserved.
PY - 2017
Y1 - 2017
N2 - BACKGROUND: Blood pressure rises with a drop in external temperature, but the role of DNA methylation in such blood pressure modulation has not been studied in detail. We evaluated blood pressure and DNA methylation of vascular disease-related genes in association with low temperature.METHODS: To examine changes in blood pressure and DNA methylation associated with low temperature, we conducted repeated measures analysis among 50 participants over 3 repeated visits, and validated the association among another 52 participants. In addition, the mean of methylation changes in the identified CpG sites was evaluated with changes in blood pressure. Mediation analyses were also conducted to model the indirect association between low ambient temperature and blood pressure through changes in DNA methylation.RESULTS: With a 1°C decrease in temperature, increases of 0.6mmHg (standard error (SE), 0.2) in SBP and 0.3mmHg (SE, 0.1) in DBP occurred (P<0.05). Of 24,490 CpG sites in vascular genes, 2 CpG sites of zinc finger (ZNF) genes were significantly associated with temperature after Bonferroni's correction in discovery and replication data. A 10% increase in methylation expression in 2 CpG sites in ZNF genes was associated with a 4-mmHg elevation in DBP (SE, 1.8; P=0.0236). The hypermethylation was attributable to the association of ambient temperature with DBP (proportion of mediation=11.8-20.4%).CONCLUSIONS: Methylation changes in ZNF genes might be involved in the elevation of blood pressure when the body is exposed to cold temperature.
AB - BACKGROUND: Blood pressure rises with a drop in external temperature, but the role of DNA methylation in such blood pressure modulation has not been studied in detail. We evaluated blood pressure and DNA methylation of vascular disease-related genes in association with low temperature.METHODS: To examine changes in blood pressure and DNA methylation associated with low temperature, we conducted repeated measures analysis among 50 participants over 3 repeated visits, and validated the association among another 52 participants. In addition, the mean of methylation changes in the identified CpG sites was evaluated with changes in blood pressure. Mediation analyses were also conducted to model the indirect association between low ambient temperature and blood pressure through changes in DNA methylation.RESULTS: With a 1°C decrease in temperature, increases of 0.6mmHg (standard error (SE), 0.2) in SBP and 0.3mmHg (SE, 0.1) in DBP occurred (P<0.05). Of 24,490 CpG sites in vascular genes, 2 CpG sites of zinc finger (ZNF) genes were significantly associated with temperature after Bonferroni's correction in discovery and replication data. A 10% increase in methylation expression in 2 CpG sites in ZNF genes was associated with a 4-mmHg elevation in DBP (SE, 1.8; P=0.0236). The hypermethylation was attributable to the association of ambient temperature with DBP (proportion of mediation=11.8-20.4%).CONCLUSIONS: Methylation changes in ZNF genes might be involved in the elevation of blood pressure when the body is exposed to cold temperature.
KW - Aged
KW - Blood Pressure/genetics
KW - CpG Islands
KW - DNA Methylation
KW - DNA-Binding Proteins/genetics
KW - Female
KW - Humans
KW - Male
KW - Republic of Korea
KW - Seasons
KW - Temperature
KW - Transcription Factors/genetics
KW - Tumor Suppressor Proteins/genetics
KW - Zinc Fingers/genetics
U2 - 10.1016/j.envres.2016.11.019
DO - 10.1016/j.envres.2016.11.019
M3 - Journal article
C2 - 27918981
VL - 153
SP - 106
EP - 111
JO - Environmental Research
JF - Environmental Research
SN - 0013-9351
ER -
ID: 230069415