Meat consumption, N-acetyl transferase 1 and 2 polymorphism and risk of breast cancer in Danish postmenopausal women

Research output: Contribution to journalJournal articleResearchpeer-review

  • Rikke Egeberg
  • Anja Olsen
  • Herman Autrup
  • Jane Christensen
  • Connie Stripp
  • Tetens, Inge
  • Kim Overvad
  • Anne Tjønneland

The aim of this study was to investigate whether polymorphisms in N-acetyl transferase 1 and 2 modify the association between meat consumption and risk of breast cancer. A nested case-control study was conducted among 24 697 postmenopausal women included in the 'Diet, Cancer and Health' cohort study (1993-2000). Three hundred and seventy-eight breast cancer cases were identified and matched to 378 controls. The incidence rate ratio (95% confidence interval) for breast cancer was 1.09 (1.02-1.17) for total meat, 1.15 (1.01-1.31) for red meat and 1.23 (1.04-1.45) for processed meat per 25 g daily increment in intake. Compared with slow acetylators, the IRR (95% confidence interval) among fast N-acetyl transferase 1 acetylators was 1.43 (1.03-1.99) and 1.13 (0.83-1.54) among intermediate/fast N-acetyl transferase 2 acetylators. Interaction analyses revealed that the positive associations between total meat intake and red meat intake and breast cancer risk were confined to intermediate/fast N-acetyl transferase 2 acetylators (Pinteraction = 0.03 and 0.04). Our findings support an association between meat consumption and breast cancer risk and that N-acetyl transferase 2 polymorphism has a modifying effect on the association, indicating that the association is confined to only genetically susceptible women.

Original languageEnglish
JournalEuropean Journal of Cancer Prevention
Issue number1
Pages (from-to)39-47
Number of pages9
Publication statusPublished - 2008
Externally publishedYes

    Research areas

  • Arylamine N-Acetyltransferase, Breast Neoplasms, Case-Control Studies, Cohort Studies, Denmark, Female, Genotype, Humans, Isoenzymes, Meat, Middle Aged, Polymorphism, Genetic, Postmenopause, Risk Factors, Comparative Study, Breast cancer, Meat consumption, NAT polymorphism, Prospective cohort study

ID: 184389995