Low birth weight, adult BMI and inflammation in middle age

Research output: Contribution to journalConference articleResearchpeer-review

This study examines the association between birthweight and adult
BMI with inflammation in middle age measured by interleukin 6 (IL-
6), interleukin 10 (IL-10), interleukin 18 (IL-18), high sensitivity Creactive
protein (hsCRP) and tumor necrosis factor alpha (tnf-α). The
study is based on participants with continued participation in the Copenhagen
Perinatal cohort and Copenhagen Aging and Midlife Biobank
clinical examination (n=1,719). Birthweight was negatively associated
with hsCRP and IL-18.No association was identified with tnf-α, IL-6
and IL-10. Adult BMI was positively and significantly associated with
all measures of inflammation besides IL-10. Finally, participants in both
the lowest tertile of birthweight and highest tertile of adult BMI had
the highest levels of all inflammatory markers. Low birthweight and
high adult BMI are risk factors for inflammation in middle age. While
the prenatal period may be sensitive for development of inflammation
it appears that modification by adult BMI occurred in this sample.
Original languageEnglish
Issue numbersuppl. 1
Pages (from-to)380
Publication statusPublished - 2013

ID: 118448788