Is GLUT4 translocation the answer to exercise stimulated muscle glucose uptake?

Research output: Contribution to journalJournal articleResearchpeer-review

Exercise increases muscle glucose uptake up to 100 fold compared to rest. The magnitude of increase depends on exercise intensity and duration. While KO of GLUT4 convincingly has shown that GLUT4 is necessary for exercise to increase muscle glucose uptake, studies only show an approximate 2-fold increase in GLUT4 translocation to the muscle cell membrane when transitioning from rest to exercise. Therefore, there is a big discrepancy between the increase in glucose uptake and GLUT4 translocation. It is suggested that either the methods for measurements of GLUT4 translocation in muscle grossly underestimate the real translocation of GLUT4 or alternatively that GLUT4 intrinsic activity increases in muscle during exercise, perhaps due to increased muscle temperature and/or mechanical effects during contraction/relaxation cycles.

Original languageEnglish
JournalAmerican Journal of Physiology: Endocrinology and Metabolism
Issue number2
Pages (from-to)E240-E243
Number of pages4
Publication statusPublished - 2021

    Research areas

  • Faculty of Science - Muscle glucose uptake, Exercise, GLUT4, Glucose transport, GLUT4 translocation

Number of downloads are based on statistics from Google Scholar and

No data available

ID: 251309578