TY - JOUR

T1 - Increased Risk of Anemia, Neutropenia, and Thrombocytopenia in People with Human Immunodeficiency Virus and Well-Controlled Viral Replication

AU - Akdag, Delal

AU - Knudsen, Andreas Dehlbæk

AU - Thudium, Rebekka Faber

AU - Kirkegaard-Klitbo, Ditte Marie

AU - Nielsen, Chivit

AU - Brown, Peter

AU - Afzal, Shoaib

AU - Nordestgaard, Børge G.

AU - Lundgren, Jens

AU - Nielsen, Susanne Dam

PY - 2019

Y1 - 2019

N2 - Background: Prior to the introduction of combination antiretroviral therapy (cART), cytopenias were common in people with human immunodeficiency virus (PWH), but it is unknown if well-controlled HIV infection is a risk factor for cytopenia. In this study we aimed to determine if HIV infection is an independent risk factor for anemia, neutropenia, lymphocytopenia, and thrombocytopenia. Methods: PWH with undetectable viral replication and absence of chronic hepatitis infection (n = 796) were recruited from the Copenhagen Comorbidity in HIV Infection (COCOMO) study and matched uninfected controls from the Copenhagen General Population Study (n = 2388). Hematology was analyzed in venous blood samples. Logistic regression analyses adjusted for age, sex, ethnicity, smoking status, alcohol, and high-sensitivity C-reactive protein were performed to determine possible associations between HIV and cytopenias. Results: PWH had a higher prevalence of anemia (6.9% vs 3.4%, P <. 001), neutropenia (1.3% vs 0.2%, P <. 001), and thrombocytopenia (5.5% vs 2.7%, P <. 001) compared with uninfected controls. HIV was independently associated with anemia-Adjusted odds ratio (aOR) of 2.0 (95% confidence interval [CI], 1.4-3.0); neutropenia aOR, 6.3 (95% CI, 2.0-19.6); and thrombocytopenia aOR, 2.7 (95% CI, 1.8-4.2). No association was found between HIV and lymphocytopenia. Conclusions: Cytopenia is rare in people with well-controlled HIV, but HIV remains a risk factor for anemia, neutropenia, and thrombocytopenia and requires ongoing attention and monitoring.

AB - Background: Prior to the introduction of combination antiretroviral therapy (cART), cytopenias were common in people with human immunodeficiency virus (PWH), but it is unknown if well-controlled HIV infection is a risk factor for cytopenia. In this study we aimed to determine if HIV infection is an independent risk factor for anemia, neutropenia, lymphocytopenia, and thrombocytopenia. Methods: PWH with undetectable viral replication and absence of chronic hepatitis infection (n = 796) were recruited from the Copenhagen Comorbidity in HIV Infection (COCOMO) study and matched uninfected controls from the Copenhagen General Population Study (n = 2388). Hematology was analyzed in venous blood samples. Logistic regression analyses adjusted for age, sex, ethnicity, smoking status, alcohol, and high-sensitivity C-reactive protein were performed to determine possible associations between HIV and cytopenias. Results: PWH had a higher prevalence of anemia (6.9% vs 3.4%, P <. 001), neutropenia (1.3% vs 0.2%, P <. 001), and thrombocytopenia (5.5% vs 2.7%, P <. 001) compared with uninfected controls. HIV was independently associated with anemia-Adjusted odds ratio (aOR) of 2.0 (95% confidence interval [CI], 1.4-3.0); neutropenia aOR, 6.3 (95% CI, 2.0-19.6); and thrombocytopenia aOR, 2.7 (95% CI, 1.8-4.2). No association was found between HIV and lymphocytopenia. Conclusions: Cytopenia is rare in people with well-controlled HIV, but HIV remains a risk factor for anemia, neutropenia, and thrombocytopenia and requires ongoing attention and monitoring.

KW - Anemia

KW - Cytopenia

KW - HIV

KW - Lymphocytopenia

KW - Neutropenia

KW - Thrombocytopenia

U2 - 10.1093/infdis/jiz394

DO - 10.1093/infdis/jiz394

M3 - Journal article

C2 - 31414119

AN - SCOPUS:85073663199

VL - 220

SP - 1834

EP - 1842

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 11

ER -