Effects of Lifetime Exposures to Environmental Contaminants on the Adult Gut Microbiome

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Effects of Lifetime Exposures to Environmental Contaminants on the Adult Gut Microbiome. / Thompson, Kelsey N.; Oulhote, Youssef; Weihe, Pal; Wilkinson, Jeremy E.; Ma, Siyuan; Zhong, Huanzi; Li, Junhua; Kristiansen, Karsten; Huttenhower, Curtis; Grandjean, Philippe.

In: Environmental Science & Technology, Vol. 56, No. 23, 2022, p. 16985-16995.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Thompson, KN, Oulhote, Y, Weihe, P, Wilkinson, JE, Ma, S, Zhong, H, Li, J, Kristiansen, K, Huttenhower, C & Grandjean, P 2022, 'Effects of Lifetime Exposures to Environmental Contaminants on the Adult Gut Microbiome', Environmental Science & Technology, vol. 56, no. 23, pp. 16985-16995. https://doi.org/10.1021/acs.est.2c03185

APA

Thompson, K. N., Oulhote, Y., Weihe, P., Wilkinson, J. E., Ma, S., Zhong, H., Li, J., Kristiansen, K., Huttenhower, C., & Grandjean, P. (2022). Effects of Lifetime Exposures to Environmental Contaminants on the Adult Gut Microbiome. Environmental Science & Technology, 56(23), 16985-16995. https://doi.org/10.1021/acs.est.2c03185

Vancouver

Thompson KN, Oulhote Y, Weihe P, Wilkinson JE, Ma S, Zhong H et al. Effects of Lifetime Exposures to Environmental Contaminants on the Adult Gut Microbiome. Environmental Science & Technology. 2022;56(23):16985-16995. https://doi.org/10.1021/acs.est.2c03185

Author

Thompson, Kelsey N. ; Oulhote, Youssef ; Weihe, Pal ; Wilkinson, Jeremy E. ; Ma, Siyuan ; Zhong, Huanzi ; Li, Junhua ; Kristiansen, Karsten ; Huttenhower, Curtis ; Grandjean, Philippe. / Effects of Lifetime Exposures to Environmental Contaminants on the Adult Gut Microbiome. In: Environmental Science & Technology. 2022 ; Vol. 56, No. 23. pp. 16985-16995.

Bibtex

@article{cf2facf9e8b1457e943b60607ab16afb,

title = "Effects of Lifetime Exposures to Environmental Contaminants on the Adult Gut Microbiome",

abstract = "Emerging experimental evidence indicates that toxicant-induced alterations in gut microbiota composition and activity may affect host homeostasis. However, data from human studies are scarce; to our knowledge, no previous studies have quantified the association of lifetime exposure to environmental chemicals, across multiple time points, with the composition of the adult gut microbiome. Here we studied 124 individuals born in the Faroe Islands in 1986-1987 who were followed approximately every seven years from birth through age 28 years. Organochlorine compounds, including polychlorinated biphenyls (PCBs) and pesticides, perfluoroalkyl substances (PFAS), and mercury (Hg), were measured in cord blood and longitudinally in participants' blood. At age 28, the gut microbiome was assessed using shotgun metagenomic sequencing. Historical contaminant exposures had little direct effect on the adult gut microbiome, while a small number of fastidious anaerobes were weakly linked to recent PFAS/ PFOS exposures at age 28. In this cohort, our findings suggest no lasting effects of early life exposures on adult gut microbial composition, but proximal exposures may contribute to gut microbiome alterations. The methods developed and used for this investigation may help in future identification of small but lasting impacts of environmental toxicant exposure on the gut microbiome.",

keywords = "gut microbiome, early life exposure, NEUROBEHAVIORAL DEFICITS, METHYLMERCURIC CHLORIDE, MERCURY, METABOLISM, HEALTH, CHAIN",

author = "Thompson, {Kelsey N.} and Youssef Oulhote and Pal Weihe and Wilkinson, {Jeremy E.} and Siyuan Ma and Huanzi Zhong and Junhua Li and Karsten Kristiansen and Curtis Huttenhower and Philippe Grandjean",

year = "2022",

doi = "10.1021/acs.est.2c03185",

language = "English",

volume = "56",

pages = "16985--16995",

journal = "Environmental Science & Technology",

issn = "0013-936X",

publisher = "American Chemical Society",

number = "23",

}

RIS

TY - JOUR

T1 - Effects of Lifetime Exposures to Environmental Contaminants on the Adult Gut Microbiome

AU - Thompson, Kelsey N.

AU - Oulhote, Youssef

AU - Weihe, Pal

AU - Wilkinson, Jeremy E.

AU - Ma, Siyuan

AU - Zhong, Huanzi

AU - Li, Junhua

AU - Kristiansen, Karsten

AU - Huttenhower, Curtis

AU - Grandjean, Philippe

PY - 2022

Y1 - 2022

N2 - Emerging experimental evidence indicates that toxicant-induced alterations in gut microbiota composition and activity may affect host homeostasis. However, data from human studies are scarce; to our knowledge, no previous studies have quantified the association of lifetime exposure to environmental chemicals, across multiple time points, with the composition of the adult gut microbiome. Here we studied 124 individuals born in the Faroe Islands in 1986-1987 who were followed approximately every seven years from birth through age 28 years. Organochlorine compounds, including polychlorinated biphenyls (PCBs) and pesticides, perfluoroalkyl substances (PFAS), and mercury (Hg), were measured in cord blood and longitudinally in participants' blood. At age 28, the gut microbiome was assessed using shotgun metagenomic sequencing. Historical contaminant exposures had little direct effect on the adult gut microbiome, while a small number of fastidious anaerobes were weakly linked to recent PFAS/ PFOS exposures at age 28. In this cohort, our findings suggest no lasting effects of early life exposures on adult gut microbial composition, but proximal exposures may contribute to gut microbiome alterations. The methods developed and used for this investigation may help in future identification of small but lasting impacts of environmental toxicant exposure on the gut microbiome.

AB - Emerging experimental evidence indicates that toxicant-induced alterations in gut microbiota composition and activity may affect host homeostasis. However, data from human studies are scarce; to our knowledge, no previous studies have quantified the association of lifetime exposure to environmental chemicals, across multiple time points, with the composition of the adult gut microbiome. Here we studied 124 individuals born in the Faroe Islands in 1986-1987 who were followed approximately every seven years from birth through age 28 years. Organochlorine compounds, including polychlorinated biphenyls (PCBs) and pesticides, perfluoroalkyl substances (PFAS), and mercury (Hg), were measured in cord blood and longitudinally in participants' blood. At age 28, the gut microbiome was assessed using shotgun metagenomic sequencing. Historical contaminant exposures had little direct effect on the adult gut microbiome, while a small number of fastidious anaerobes were weakly linked to recent PFAS/ PFOS exposures at age 28. In this cohort, our findings suggest no lasting effects of early life exposures on adult gut microbial composition, but proximal exposures may contribute to gut microbiome alterations. The methods developed and used for this investigation may help in future identification of small but lasting impacts of environmental toxicant exposure on the gut microbiome.

KW - gut microbiome

KW - early life exposure

KW - NEUROBEHAVIORAL DEFICITS

KW - METHYLMERCURIC CHLORIDE

KW - MERCURY

KW - METABOLISM

KW - HEALTH

KW - CHAIN

U2 - 10.1021/acs.est.2c03185

DO - 10.1021/acs.est.2c03185

M3 - Journal article

C2 - 36394280

VL - 56

SP - 16985

EP - 16995

JO - Environmental Science & Technology

JF - Environmental Science & Technology

SN - 0013-936X

IS - 23

ER -

ID: 329572441