Differential transcriptional responses to Ebola and Marburg virus infection in bat and human cells: [Plus] Corrigendum
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Differential transcriptional responses to Ebola and Marburg virus infection in bat and human cells : [Plus] Corrigendum. / Hölzer, Martin; Krähling, Verena; Amman, Fabian; Barth, Emanuel; Bernhart, Stephan H.; Carmelo, Victor Adriano Okstoft; Collatz, Maximilian; Doose, Gero; Eggenhofer, Florian; Ewald, Jan; Fallmann, Jörg; Feldhahn, Lasse M.; Fricke, Markus; Gebauer, Juliane; Gruber, Andreas J.; Hufsky, Franziska; Indrischek, Henrike; Kanton, Sabina; Linde, Jörg; Mostajo, Nelly; Ochsenreiter, Roman; Riege, Konstantin; Rivarola-Duarte, Lorena; Sahyoun, Abdullah H.; Saunders, Sita J.; Seemann, Ernst Stefan; Tanzer, Andrea; Vogel, Bertram; Wehner, Stefanie; Wolfinger, Michael T.; Backofen, Rolf; Gorodkin, Jan; Grosse, Ivo; Hofacker, Ivo; Hoffmann, Steve; Kaleta, Christoph; Stadler, Peter F.; Becker, Stephan; Marz, Manja.
In: Scientific Reports, Vol. 6, 34589, 07.10.2016.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Differential transcriptional responses to Ebola and Marburg virus infection in bat and human cells
T2 - [Plus] Corrigendum
AU - Hölzer, Martin
AU - Krähling, Verena
AU - Amman, Fabian
AU - Barth, Emanuel
AU - Bernhart, Stephan H.
AU - Carmelo, Victor Adriano Okstoft
AU - Collatz, Maximilian
AU - Doose, Gero
AU - Eggenhofer, Florian
AU - Ewald, Jan
AU - Fallmann, Jörg
AU - Feldhahn, Lasse M.
AU - Fricke, Markus
AU - Gebauer, Juliane
AU - Gruber, Andreas J.
AU - Hufsky, Franziska
AU - Indrischek, Henrike
AU - Kanton, Sabina
AU - Linde, Jörg
AU - Mostajo, Nelly
AU - Ochsenreiter, Roman
AU - Riege, Konstantin
AU - Rivarola-Duarte, Lorena
AU - Sahyoun, Abdullah H.
AU - Saunders, Sita J.
AU - Seemann, Ernst Stefan
AU - Tanzer, Andrea
AU - Vogel, Bertram
AU - Wehner, Stefanie
AU - Wolfinger, Michael T.
AU - Backofen, Rolf
AU - Gorodkin, Jan
AU - Grosse, Ivo
AU - Hofacker, Ivo
AU - Hoffmann, Steve
AU - Kaleta, Christoph
AU - Stadler, Peter F.
AU - Becker, Stephan
AU - Marz, Manja
PY - 2016/10/7
Y1 - 2016/10/7
N2 - The unprecedented outbreak of Ebola in West Africa resulted in over 28,000 cases and 11,000 deaths, underlining the need for a better understanding of the biology of this highly pathogenic virus to develop specific counter strategies. Two filoviruses, the Ebola and Marburg viruses, result in a severe and often fatal infection in humans. However, bats are natural hosts and survive filovirus infections without obvious symptoms. The molecular basis of this striking difference in the response to filovirus infections is not well understood. We report a systematic overview of differentially expressed genes, activity motifs and pathways in human and bat cells infected with the Ebola and Marburg viruses, and we demonstrate that the replication of filoviruses is more rapid in human cells than in bat cells. We also found that the most strongly regulated genes upon filovirus infection are chemokine ligands and transcription factors. We observed a strong induction of the JAK/STAT pathway, of several genes encoding inhibitors of MAP kinases (DUSP genes) and of PPP1R15A, which is involved in ER stress-induced cell death. We used comparative transcriptomics to provide a data resource that can be used to identify cellular responses that might allow bats to survive filovirus infections.
AB - The unprecedented outbreak of Ebola in West Africa resulted in over 28,000 cases and 11,000 deaths, underlining the need for a better understanding of the biology of this highly pathogenic virus to develop specific counter strategies. Two filoviruses, the Ebola and Marburg viruses, result in a severe and often fatal infection in humans. However, bats are natural hosts and survive filovirus infections without obvious symptoms. The molecular basis of this striking difference in the response to filovirus infections is not well understood. We report a systematic overview of differentially expressed genes, activity motifs and pathways in human and bat cells infected with the Ebola and Marburg viruses, and we demonstrate that the replication of filoviruses is more rapid in human cells than in bat cells. We also found that the most strongly regulated genes upon filovirus infection are chemokine ligands and transcription factors. We observed a strong induction of the JAK/STAT pathway, of several genes encoding inhibitors of MAP kinases (DUSP genes) and of PPP1R15A, which is involved in ER stress-induced cell death. We used comparative transcriptomics to provide a data resource that can be used to identify cellular responses that might allow bats to survive filovirus infections.
UR - http://10.1038/srep39421
U2 - 10.1038/srep34589
DO - 10.1038/srep34589
M3 - Journal article
C2 - 27713552
VL - 6
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
M1 - 34589
ER -
ID: 168324938