Dietary and Circulating Fatty Acids and Ovarian Cancer Risk in the European Prospective Investigation into Cancer and Nutrition

Research output: Contribution to journal › Journal article › Research › peer-review

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Dietary and Circulating Fatty Acids and Ovarian Cancer Risk in the European Prospective Investigation into Cancer and Nutrition. / Yammine, Sahar; Huybrechts, Inge; Biessy, Carine; Dossus, Laure; Aglago, Elom K.; Naudin, Sabine; Ferrari, Pietro; Weiderpass, Elisabete; Tjønneland, Anne; Hansen, Louise; Overvad, Kim; Mancini, Francesca R.; Boutron-Ruault, Marie-Christine; Kvaskoff, Marina; Fortner, Renee T.; Kaaks, Rudolf; Schulze, Matthias B.; Boeing, Heiner; Trichopoulou, Antonia; Karakatsani, Anna; La Vecchia, Carlo; Benetou, Vassiliki; Masala, Giovanna; Krogh, Vittorio; Mattiello, Amalia; Macciotta, Alessandra; Gram, Inger T.; Skeie, Guri; Quiros, Jose R.; Agudo, Antonio; Sanchez, Maria-Jose; Chirlaque, Maria-Dolores; Ardanaz, Eva; Gil, Leire; Sartor, Hanna; Drake, Isabel; Idahl, Annika; Lundin, Eva; Aune, Dagfinn; Ward, Heather; Merritt, Melissa A.; Allen, Naomi E.; Gunter, Marc J.; Chajes, Veronique.

In: Cancer Epidemiology, Biomarkers & Prevention, Vol. 29, No. 9, 2020, p. 1739-1749.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Yammine, S, Huybrechts, I, Biessy, C, Dossus, L, Aglago, EK, Naudin, S, Ferrari, P, Weiderpass, E, Tjønneland, A, Hansen, L, Overvad, K, Mancini, FR, Boutron-Ruault, M-C, Kvaskoff, M, Fortner, RT, Kaaks, R, Schulze, MB, Boeing, H, Trichopoulou, A, Karakatsani, A, La Vecchia, C, Benetou, V, Masala, G, Krogh, V, Mattiello, A, Macciotta, A, Gram, IT, Skeie, G, Quiros, JR, Agudo, A, Sanchez, M-J, Chirlaque, M-D, Ardanaz, E, Gil, L, Sartor, H, Drake, I, Idahl, A, Lundin, E, Aune, D, Ward, H, Merritt, MA, Allen, NE, Gunter, MJ & Chajes, V 2020, 'Dietary and Circulating Fatty Acids and Ovarian Cancer Risk in the European Prospective Investigation into Cancer and Nutrition', Cancer Epidemiology, Biomarkers & Prevention, vol. 29, no. 9, pp. 1739-1749. https://doi.org/10.1158/1055-9965.EPI-19-1477

APA

Yammine, S., Huybrechts, I., Biessy, C., Dossus, L., Aglago, E. K., Naudin, S., Ferrari, P., Weiderpass, E., Tjønneland, A., Hansen, L., Overvad, K., Mancini, F. R., Boutron-Ruault, M-C., Kvaskoff, M., Fortner, R. T., Kaaks, R., Schulze, M. B., Boeing, H., Trichopoulou, A., ... Chajes, V. (2020). Dietary and Circulating Fatty Acids and Ovarian Cancer Risk in the European Prospective Investigation into Cancer and Nutrition. Cancer Epidemiology, Biomarkers & Prevention, 29(9), 1739-1749. https://doi.org/10.1158/1055-9965.EPI-19-1477

Vancouver

Yammine S, Huybrechts I, Biessy C, Dossus L, Aglago EK, Naudin S et al. Dietary and Circulating Fatty Acids and Ovarian Cancer Risk in the European Prospective Investigation into Cancer and Nutrition. Cancer Epidemiology, Biomarkers & Prevention. 2020;29(9):1739-1749. https://doi.org/10.1158/1055-9965.EPI-19-1477

Author

Yammine, Sahar ; Huybrechts, Inge ; Biessy, Carine ; Dossus, Laure ; Aglago, Elom K. ; Naudin, Sabine ; Ferrari, Pietro ; Weiderpass, Elisabete ; Tjønneland, Anne ; Hansen, Louise ; Overvad, Kim ; Mancini, Francesca R. ; Boutron-Ruault, Marie-Christine ; Kvaskoff, Marina ; Fortner, Renee T. ; Kaaks, Rudolf ; Schulze, Matthias B. ; Boeing, Heiner ; Trichopoulou, Antonia ; Karakatsani, Anna ; La Vecchia, Carlo ; Benetou, Vassiliki ; Masala, Giovanna ; Krogh, Vittorio ; Mattiello, Amalia ; Macciotta, Alessandra ; Gram, Inger T. ; Skeie, Guri ; Quiros, Jose R. ; Agudo, Antonio ; Sanchez, Maria-Jose ; Chirlaque, Maria-Dolores ; Ardanaz, Eva ; Gil, Leire ; Sartor, Hanna ; Drake, Isabel ; Idahl, Annika ; Lundin, Eva ; Aune, Dagfinn ; Ward, Heather ; Merritt, Melissa A. ; Allen, Naomi E. ; Gunter, Marc J. ; Chajes, Veronique. / Dietary and Circulating Fatty Acids and Ovarian Cancer Risk in the European Prospective Investigation into Cancer and Nutrition. In: Cancer Epidemiology, Biomarkers & Prevention. 2020 ; Vol. 29, No. 9. pp. 1739-1749.

Bibtex

@article{53cfd60db4c044b3bcd95f62f960d33f,

title = "Dietary and Circulating Fatty Acids and Ovarian Cancer Risk in the European Prospective Investigation into Cancer and Nutrition",

abstract = "Background: Fatty acids impact obesity, estrogens, and inflammation, which are risk factors for ovarian cancer. Few epidemiologic studies have investigated the association of fatty acids with ovarian cancer.Methods: Within the European Prospective Investigation into Cancer and Nutrition (EPIC), 1,486 incident ovarian cancer cases were identified. Cox proportional hazard models with adjustment for ovarian cancer risk factors were used to estimate HRs of ovarian cancer across quintiles of intake of fatty acids. False discovery rate was computed to control for multiple testing. Multivariable conditional logistic regression models were used to estimate ORs of ovarian cancer across tertiles of plasma fatty acids among 633 cases and two matched controls in a nested case-control analysis.Results: Apositive association was found between ovarian cancer and intake of industrial trans elaidic acid [HR comparing fifth with first quintile(Q5-Q1) = 1.29; 95% confidence interval (CI) = 1.03-1.62; P-trend = 0.02, q-value = 0.06]. Dietary intakes of n-6 linoleic acid (HRQ5-Q1 = 1.10; 95% CI = 1.01-1.21; P-trend = 0.03) and n-3 alpha-linolenic acid (HRQ5-Q1 = 1.18; 95% CI = 1.05-1.34; P-trend = 0.007) from deep-frying fats were also positively associated with ovarian cancer. Suggestive associations were reported for circulating elaidic (OR comparing third with first tertile(T3-T1) = 1.39; 95% CI = 0.99-1.94; P-trend = 0.06) anda-linolenic acids (ORT3-T1 = 1.30; 95% CI = 0.98-1.72; P-trend = 0.06).Conclusions: Our results suggest that higher intakes and circulating levels of industrial trans elaidic acid, and higher intakes of linoleic acid and alpha-linolenic acid from deep-frying fat, may be associated with greater risk of ovarian cancer.Impact: If causal, eliminating industrial trans-fatty acids could offer a straightforward public health action for reducing ovarian cancer risk.",

keywords = "EPIC PROJECT, DATABASE",

author = "Sahar Yammine and Inge Huybrechts and Carine Biessy and Laure Dossus and Aglago, {Elom K.} and Sabine Naudin and Pietro Ferrari and Elisabete Weiderpass and Anne Tj{\o}nneland and Louise Hansen and Kim Overvad and Mancini, {Francesca R.} and Marie-Christine Boutron-Ruault and Marina Kvaskoff and Fortner, {Renee T.} and Rudolf Kaaks and Schulze, {Matthias B.} and Heiner Boeing and Antonia Trichopoulou and Anna Karakatsani and {La Vecchia}, Carlo and Vassiliki Benetou and Giovanna Masala and Vittorio Krogh and Amalia Mattiello and Alessandra Macciotta and Gram, {Inger T.} and Guri Skeie and Quiros, {Jose R.} and Antonio Agudo and Maria-Jose Sanchez and Maria-Dolores Chirlaque and Eva Ardanaz and Leire Gil and Hanna Sartor and Isabel Drake and Annika Idahl and Eva Lundin and Dagfinn Aune and Heather Ward and Merritt, {Melissa A.} and Allen, {Naomi E.} and Gunter, {Marc J.} and Veronique Chajes",

year = "2020",

doi = "10.1158/1055-9965.EPI-19-1477",

language = "English",

volume = "29",

pages = "1739--1749",

journal = "Cancer Epidemiology, Biomarkers & Prevention",

issn = "1055-9965",

publisher = "American Association for Cancer Research (A A C R)",

number = "9",

}

RIS

TY - JOUR

T1 - Dietary and Circulating Fatty Acids and Ovarian Cancer Risk in the European Prospective Investigation into Cancer and Nutrition

AU - Yammine, Sahar

AU - Huybrechts, Inge

AU - Biessy, Carine

AU - Dossus, Laure

AU - Aglago, Elom K.

AU - Naudin, Sabine

AU - Ferrari, Pietro

AU - Weiderpass, Elisabete

AU - Tjønneland, Anne

AU - Hansen, Louise

AU - Overvad, Kim

AU - Mancini, Francesca R.

AU - Boutron-Ruault, Marie-Christine

AU - Kvaskoff, Marina

AU - Fortner, Renee T.

AU - Kaaks, Rudolf

AU - Schulze, Matthias B.

AU - Boeing, Heiner

AU - Trichopoulou, Antonia

AU - Karakatsani, Anna

AU - La Vecchia, Carlo

AU - Benetou, Vassiliki

AU - Masala, Giovanna

AU - Krogh, Vittorio

AU - Mattiello, Amalia

AU - Macciotta, Alessandra

AU - Gram, Inger T.

AU - Skeie, Guri

AU - Quiros, Jose R.

AU - Agudo, Antonio

AU - Sanchez, Maria-Jose

AU - Chirlaque, Maria-Dolores

AU - Ardanaz, Eva

AU - Gil, Leire

AU - Sartor, Hanna

AU - Drake, Isabel

AU - Idahl, Annika

AU - Lundin, Eva

AU - Aune, Dagfinn

AU - Ward, Heather

AU - Merritt, Melissa A.

AU - Allen, Naomi E.

AU - Gunter, Marc J.

AU - Chajes, Veronique

PY - 2020

Y1 - 2020

N2 - Background: Fatty acids impact obesity, estrogens, and inflammation, which are risk factors for ovarian cancer. Few epidemiologic studies have investigated the association of fatty acids with ovarian cancer.Methods: Within the European Prospective Investigation into Cancer and Nutrition (EPIC), 1,486 incident ovarian cancer cases were identified. Cox proportional hazard models with adjustment for ovarian cancer risk factors were used to estimate HRs of ovarian cancer across quintiles of intake of fatty acids. False discovery rate was computed to control for multiple testing. Multivariable conditional logistic regression models were used to estimate ORs of ovarian cancer across tertiles of plasma fatty acids among 633 cases and two matched controls in a nested case-control analysis.Results: Apositive association was found between ovarian cancer and intake of industrial trans elaidic acid [HR comparing fifth with first quintile(Q5-Q1) = 1.29; 95% confidence interval (CI) = 1.03-1.62; P-trend = 0.02, q-value = 0.06]. Dietary intakes of n-6 linoleic acid (HRQ5-Q1 = 1.10; 95% CI = 1.01-1.21; P-trend = 0.03) and n-3 alpha-linolenic acid (HRQ5-Q1 = 1.18; 95% CI = 1.05-1.34; P-trend = 0.007) from deep-frying fats were also positively associated with ovarian cancer. Suggestive associations were reported for circulating elaidic (OR comparing third with first tertile(T3-T1) = 1.39; 95% CI = 0.99-1.94; P-trend = 0.06) anda-linolenic acids (ORT3-T1 = 1.30; 95% CI = 0.98-1.72; P-trend = 0.06).Conclusions: Our results suggest that higher intakes and circulating levels of industrial trans elaidic acid, and higher intakes of linoleic acid and alpha-linolenic acid from deep-frying fat, may be associated with greater risk of ovarian cancer.Impact: If causal, eliminating industrial trans-fatty acids could offer a straightforward public health action for reducing ovarian cancer risk.

AB - Background: Fatty acids impact obesity, estrogens, and inflammation, which are risk factors for ovarian cancer. Few epidemiologic studies have investigated the association of fatty acids with ovarian cancer.Methods: Within the European Prospective Investigation into Cancer and Nutrition (EPIC), 1,486 incident ovarian cancer cases were identified. Cox proportional hazard models with adjustment for ovarian cancer risk factors were used to estimate HRs of ovarian cancer across quintiles of intake of fatty acids. False discovery rate was computed to control for multiple testing. Multivariable conditional logistic regression models were used to estimate ORs of ovarian cancer across tertiles of plasma fatty acids among 633 cases and two matched controls in a nested case-control analysis.Results: Apositive association was found between ovarian cancer and intake of industrial trans elaidic acid [HR comparing fifth with first quintile(Q5-Q1) = 1.29; 95% confidence interval (CI) = 1.03-1.62; P-trend = 0.02, q-value = 0.06]. Dietary intakes of n-6 linoleic acid (HRQ5-Q1 = 1.10; 95% CI = 1.01-1.21; P-trend = 0.03) and n-3 alpha-linolenic acid (HRQ5-Q1 = 1.18; 95% CI = 1.05-1.34; P-trend = 0.007) from deep-frying fats were also positively associated with ovarian cancer. Suggestive associations were reported for circulating elaidic (OR comparing third with first tertile(T3-T1) = 1.39; 95% CI = 0.99-1.94; P-trend = 0.06) anda-linolenic acids (ORT3-T1 = 1.30; 95% CI = 0.98-1.72; P-trend = 0.06).Conclusions: Our results suggest that higher intakes and circulating levels of industrial trans elaidic acid, and higher intakes of linoleic acid and alpha-linolenic acid from deep-frying fat, may be associated with greater risk of ovarian cancer.Impact: If causal, eliminating industrial trans-fatty acids could offer a straightforward public health action for reducing ovarian cancer risk.

KW - EPIC PROJECT

KW - DATABASE

U2 - 10.1158/1055-9965.EPI-19-1477

DO - 10.1158/1055-9965.EPI-19-1477

M3 - Journal article

C2 - 32616494

VL - 29

SP - 1739

EP - 1749

JO - Cancer Epidemiology, Biomarkers & Prevention

JF - Cancer Epidemiology, Biomarkers & Prevention

SN - 1055-9965

IS - 9

ER -

ID: 248848553