Coating of bone implants with silica, hyperbranched polyethyleneimine, and gentamicin prevents development of osteomyelitis in a porcine model

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  • Mats Bue
  • Pelle Hanberg
  • Yuly López
  • Sara M. Soto
  • Marilina Douloudi
  • Michaela Papageorgiou
  • Eleni Nikoli
  • Michael Arkas
  • Ignacio Gutiérrez-del-Río
  • Sara López-Ibáñez
  • Claudio J. Villar
  • Felipe Lombó
  • Paraskevi Gkomoza
  • Ioanna Kitsou
  • Athina Tsetsekou
  • Michalis Vardavoulias

The use of bone implants and prostheses has contributed to a revolution in modern medicine; however, in the beginning, not much was asked from the implant and prosthetic materials per se. Therefore, the next game-changer in orthopedic research will come from new material designs which for instance can aid in prevention of implant-associated bone infections. Here, we describe the development of a new sol-gel coating technique that can deliver an efficient antimicrobial surface coating on orthopedic implants. Gentamicin was stocked in a novel nanocomposite xerogel made from silica and hyperbranched polyethyleneimine. The xerogel was anchored inside a porous surface made by coating of bone implants with titanium microspheres. Thereby, only the small water-soluble gentamicin molecules diffused in an aqueous environment, i.e., just after surgical insertion and leaving behind a titanium scaffold for osseointegration. The novel xerogel coating prevented development of severe Staphylococcus aureus induced osteomyelitis in a porcine model, which untreated, replicated the pathology seen in stage 3A on the Cierny–Mader classification system for osteomyelitis in adults.

Original languageEnglish
Article number101473
Publication statusPublished - 2022

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© 2022 The Authors

    Research areas

  • Antibacterial coating, Bone implants, Osteomyelitis, Porcine model

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