An antileishmanial chalcone from Chinese licorice roots

Research output: Contribution to journalJournal articleResearchpeer-review

A bioassay guided fractionation of an extract of Chinese licorice roots led to the isolation of (E)-1-[2,4-dihydroxy-3-(3-methyl-2-butenyl)phenyl]-3-[4- hydroxy-3-(3-methyl-2-butenyl]phenyl-2-propen-1-one, which in vitro showed potent antileishmanial activity. In addition, the novel chalcone (E)-1-[2,4-dihydroxy-3-(3-methyl-2- butenyl)phenyl]-3-(2,2-dimethyl-8-hydroxy-2H-benzopyran-6-yl)-2-prope n-1-one was isolated from the roots. The latter compound only showed antileishmanial activity at high concentrations.
Original languageEnglish
JournalPlanta Medica
Issue number2
Pages (from-to)121-3
Number of pages2
Publication statusPublished - 1994

Bibliographical note

Keywords: Animals; Antiprotozoal Agents; Chalcone; Chalcones; China; Glycyrrhiza; Leishmania donovani; Magnetic Resonance Spectroscopy; Molecular Structure; Plants, Medicinal

ID: 6766658