Activation of the renal GLP-1R leads to expression of Ren1 in the renal vascular tree
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Activation of the renal GLP-1R leads to expression of Ren1 in the renal vascular tree. / Bjørnholm, Katrine Dahl; Ougaard, Maria Elm; Skovsted, Gry Freja; Knudsen, Lotte Bjerre; Pyke, Charles.
In: Endocrinology, Diabetes and Metabolism, Vol. 4, No. 3, e00234, 2021.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Activation of the renal GLP-1R leads to expression of Ren1 in the renal vascular tree
AU - Bjørnholm, Katrine Dahl
AU - Ougaard, Maria Elm
AU - Skovsted, Gry Freja
AU - Knudsen, Lotte Bjerre
AU - Pyke, Charles
PY - 2021
Y1 - 2021
N2 - The GLP-1 receptor (GLP-1R) in the kidney is expressed exclusively in vascular smooth muscle cells in arteries and arterioles. Downstream effects of the activation of the renal vascular GLP-1R are elusive but may involve regulation of the renin-angiotensin-aldosterone system (RAAS). The expression of Ren1 in the mouse renal vasculature was investigated by in situ hybridization after a single subcutaneous dose of liraglutide, semaglutide and after repeated injections of liraglutide. Single and repeated exposure to GLP-1R agonists induced expression of Ren1 in the renal vascular smooth muscle cell compartment compared with vehicle injected controls (p <.0001) for both semaglutide and liraglutide. The present data show a robust induction of Ren1 expression in the vascular smooth muscle cells of the kidney after single and repeated GLP-1R activation and this renin recruitment may be involved in the effects of GLP-1R agonist treatment on kidney disease.
AB - The GLP-1 receptor (GLP-1R) in the kidney is expressed exclusively in vascular smooth muscle cells in arteries and arterioles. Downstream effects of the activation of the renal vascular GLP-1R are elusive but may involve regulation of the renin-angiotensin-aldosterone system (RAAS). The expression of Ren1 in the mouse renal vasculature was investigated by in situ hybridization after a single subcutaneous dose of liraglutide, semaglutide and after repeated injections of liraglutide. Single and repeated exposure to GLP-1R agonists induced expression of Ren1 in the renal vascular smooth muscle cell compartment compared with vehicle injected controls (p <.0001) for both semaglutide and liraglutide. The present data show a robust induction of Ren1 expression in the vascular smooth muscle cells of the kidney after single and repeated GLP-1R activation and this renin recruitment may be involved in the effects of GLP-1R agonist treatment on kidney disease.
KW - GLP-1
KW - GLP-1 receptor
KW - GLP-1R agonists
KW - in situ hybridization
KW - renal vasculature
KW - renin recruitment
U2 - 10.1002/edm2.234
DO - 10.1002/edm2.234
M3 - Journal article
C2 - 34277961
AN - SCOPUS:85102654727
VL - 4
JO - Endocrinology, Diabetes and Metabolism
JF - Endocrinology, Diabetes and Metabolism
SN - 2398-9238
IS - 3
M1 - e00234
ER -
ID: 259101357