A Simplified Model Structure for Compression Characterization of Pharmaceutical Tablets
Research output: Contribution to journal › Journal article › Research › peer-review
Despite -or maybe because- many shortcomings, Heckel's equation is by far the most investigated compressibility model for decades. The somewhat overlooked Gurnham equation is proposed as a more stable and better fitting compressibility model. Combining this equation with a linear model for the strength/pressure relation provides a composite function identical with the often-used Ryshkewitch equation for the relation between strength and porosity. It is thus questioned whether the three-dimensional compression characterization presented in USP monograph <1062> is correct. Substantial errors in computed parameters are revealed with consequences for reproducibility or inter-lab assessments. Elastic recovery is proposed as a more interesting and relevant characteristic in relation to pharmaceutical tablet formulation.
Original language | English |
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Journal | Journal of Pharmaceutical Sciences |
Volume | 111 |
Issue number | 11 |
Pages (from-to) | 3088-3095 |
ISSN | 0022-3549 |
DOIs | |
Publication status | Published - 2022 |
- Compaction, Compression, Factorial design, Mathematical models, Tablets
Research areas
ID: 318194893