A critical period of corticomuscular and EMG-EMG coherence detection in healthy infants aged 9-25weeks
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A critical period of corticomuscular and EMG-EMG coherence detection in healthy infants aged 9-25weeks. / Ritterband-Rosenbaum, Anina; Herskind, Anna; Li, Xi; Willerslev-Olsen, Maria; Olsen, Mikkel Damgaard; Farmer, Simon Francis; Nielsen, Jens Bo.
In: The Journal of Physiology, Vol. 595, No. 8, 15.04.2017, p. 2699-2713.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - A critical period of corticomuscular and EMG-EMG coherence detection in healthy infants aged 9-25weeks
AU - Ritterband-Rosenbaum, Anina
AU - Herskind, Anna
AU - Li, Xi
AU - Willerslev-Olsen, Maria
AU - Olsen, Mikkel Damgaard
AU - Farmer, Simon Francis
AU - Nielsen, Jens Bo
PY - 2017/4/15
Y1 - 2017/4/15
N2 - The early postnatal development of functional corticospinal connections in human infants is not fully clarified. We used EEG and EMG to investigate the development of corticomuscular and intramuscular coherence as indicators of functional corticospinal connectivity in healthy infants aged 1–66 weeks. EEG was recorded over leg and hand area of motor cortex. EMG recordings were made from right ankle dorsiflexor and right wrist extensor muscles. Quantification of the amount of corticomuscular coherence in the 20–40 Hz frequency band showed a significantly larger coherence for infants aged 9–25 weeks compared to younger and older infants. Coherence between paired EMG recordings from tibialis anterior muscle in the 20–40 Hz frequency band was also significantly larger for the 9–25 week age group. A low-amplitude, broad-duration (40–50 ms) central peak of EMG–EMG synchronization was observed for infants younger than 9 weeks, whereas a short-lasting (10–20 ms) central peak was observed for EMG–EMG synchronization in older infants. This peak was largest for infants aged 9–25 weeks. These data suggest that the corticospinal drive to lower and upper limb muscles shows significant developmental changes with an increase in functional coupling in infants aged 9–25 weeks, a period which coincides partly with the developmental period of normal fidgety movements. We propose that these neurophysiological findings may reflect the existence of a sensitive period where the functional connections between corticospinal tract fibres and spinal motoneurones undergo activity-dependent reorganization. This may be relevant for the timing of early therapy interventions in infants with pre- and perinatal brain injury.
AB - The early postnatal development of functional corticospinal connections in human infants is not fully clarified. We used EEG and EMG to investigate the development of corticomuscular and intramuscular coherence as indicators of functional corticospinal connectivity in healthy infants aged 1–66 weeks. EEG was recorded over leg and hand area of motor cortex. EMG recordings were made from right ankle dorsiflexor and right wrist extensor muscles. Quantification of the amount of corticomuscular coherence in the 20–40 Hz frequency band showed a significantly larger coherence for infants aged 9–25 weeks compared to younger and older infants. Coherence between paired EMG recordings from tibialis anterior muscle in the 20–40 Hz frequency band was also significantly larger for the 9–25 week age group. A low-amplitude, broad-duration (40–50 ms) central peak of EMG–EMG synchronization was observed for infants younger than 9 weeks, whereas a short-lasting (10–20 ms) central peak was observed for EMG–EMG synchronization in older infants. This peak was largest for infants aged 9–25 weeks. These data suggest that the corticospinal drive to lower and upper limb muscles shows significant developmental changes with an increase in functional coupling in infants aged 9–25 weeks, a period which coincides partly with the developmental period of normal fidgety movements. We propose that these neurophysiological findings may reflect the existence of a sensitive period where the functional connections between corticospinal tract fibres and spinal motoneurones undergo activity-dependent reorganization. This may be relevant for the timing of early therapy interventions in infants with pre- and perinatal brain injury.
U2 - 10.1113/JP273090
DO - 10.1113/JP273090
M3 - Journal article
C2 - 28004392
VL - 595
SP - 2699
EP - 2713
JO - The Journal of Physiology
JF - The Journal of Physiology
SN - 0022-3751
IS - 8
ER -
ID: 182543672