Zinc intake, zinc status and growth in a longitudinal study of healthy Danish infants
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Zinc intake, zinc status and growth in a longitudinal study of healthy Danish infants. / Michaelsen, Kim F.; Samuelson, G; Graham, T W; Lönnerdal, B.
In: Acta Pædiatrica, Vol. 83, No. 11, 1994, p. 1115-1121.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Zinc intake, zinc status and growth in a longitudinal study of healthy Danish infants
AU - Michaelsen, Kim F.
AU - Samuelson, G
AU - Graham, T W
AU - Lönnerdal, B
PY - 1994
Y1 - 1994
N2 - Mild, growth-limiting zinc deficiency might be prevalent in otherwise healthy infants according to recent studies. We examined zinc intake and status in 91 healthy term infants from birth to 12 months, as part of the Copenhagen Cohort Study on Infant Nutrition and Growth. Zinc intake was recorded monthly and the amount of zinc absorbed was estimated. These estimates were below recently published FAO/WHO/IAEA values for basal requirements in 68%, 62% and 14% of the infants at 2, 4 and 9 months of age, respectively. Serum zinc decreased significantly (p < 0.01) from 10.6 μmol/l at 6 months to 8.4μmol/1 at 9 months of age (normal range 10-18 μmol/l). Erythrocyte metallothionein values, a tentative indicator of long-term zinc status, decreased significantly from 2 to 6 months (p < 0.001) and from 6 to 9 months (p < 0.01). Serum zinc at 9 months was positively associated with growth velocity during the period from 6 to 9 months (weight: p = 0.05; knee-heel length: p = 0.002). The results provide descriptive data on zinc intake and zinc status in healthy Danish infants. Although some of our data suggest suboptimal zinc status during late infancy, evidence for this can only be obtained through a randomized intervention study.
AB - Mild, growth-limiting zinc deficiency might be prevalent in otherwise healthy infants according to recent studies. We examined zinc intake and status in 91 healthy term infants from birth to 12 months, as part of the Copenhagen Cohort Study on Infant Nutrition and Growth. Zinc intake was recorded monthly and the amount of zinc absorbed was estimated. These estimates were below recently published FAO/WHO/IAEA values for basal requirements in 68%, 62% and 14% of the infants at 2, 4 and 9 months of age, respectively. Serum zinc decreased significantly (p < 0.01) from 10.6 μmol/l at 6 months to 8.4μmol/1 at 9 months of age (normal range 10-18 μmol/l). Erythrocyte metallothionein values, a tentative indicator of long-term zinc status, decreased significantly from 2 to 6 months (p < 0.001) and from 6 to 9 months (p < 0.01). Serum zinc at 9 months was positively associated with growth velocity during the period from 6 to 9 months (weight: p = 0.05; knee-heel length: p = 0.002). The results provide descriptive data on zinc intake and zinc status in healthy Danish infants. Although some of our data suggest suboptimal zinc status during late infancy, evidence for this can only be obtained through a randomized intervention study.
KW - Breast feeding
KW - Erytrocyte metallothionein
KW - Infant nutrition
KW - Weaning foods
KW - Zinc deficiency
UR - http://www.scopus.com/inward/record.url?scp=0028113917&partnerID=8YFLogxK
U2 - 10.1111/j.1651-2227.1994.tb18262.x
DO - 10.1111/j.1651-2227.1994.tb18262.x
M3 - Journal article
C2 - 7841721
AN - SCOPUS:0028113917
VL - 83
SP - 1115
EP - 1121
JO - Acta Paediatrica
JF - Acta Paediatrica
SN - 0803-5253
IS - 11
ER -
ID: 258031828