White matter maturation during 12 months in individuals at ultra-high-risk for psychosis
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White matter maturation during 12 months in individuals at ultra-high-risk for psychosis. / Krakauer, K; Nordentoft, M.; Glenthøj, B.Y.; Raghava, J M; Nordholm, D; Randers, L.; Glenthøj, L B; Ebdrup, B.H.; Rostrup, E.
In: Acta Psychiatrica Scandinavica, Vol. 137, No. 1, 2018, p. 65-78.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - White matter maturation during 12 months in individuals at ultra-high-risk for psychosis
AU - Krakauer, K
AU - Nordentoft, M.
AU - Glenthøj, B.Y.
AU - Raghava, J M
AU - Nordholm, D
AU - Randers, L.
AU - Glenthøj, L B
AU - Ebdrup, B.H.
AU - Rostrup, E.
N1 - © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
PY - 2018
Y1 - 2018
N2 - OBJECTIVE: The neurodevelopmental hypothesis of psychosis suggests that disrupted white matter (WM) maturation underlies disease onset. In this longitudinal study, we investigated WM connectivity and compared WM changes between individuals at ultra-high-risk for psychosis (UHR) and healthy controls (HCs).METHOD: Thirty UHR individuals and 23 HCs underwent MR diffusion tensor imaging before and after 12 months of non-manualized standard care. Positive and negative symptoms and level of functioning were assessed. Tract-based spatial statistics were employed.RESULTS: During 12 months, none of the UHR individuals transitioned to psychosis. Both UHR individuals and HCs increased significantly in fractional anisotropy (FA). UHR individuals showed significant FA increases predominantly in the left superior longitudinal fasciculus (SLF) (P = 0.01), and HCs showed significant FA increases in the left uncinate fasciculus (P = 0.03). Within UHR individuals, a significant positive correlation between FA change and age was observed predominantly in the left SLF (P = 0.02). Within HCs, no significant correlation between FA change and age was observed. No significant correlations between baseline FA and clinical outcomes were observed; however, FA changes were significantly positively correlated to changes in negative symptoms (P = 0.04).CONCLUSION: As normal brain maturation occurs in a posterior to frontal direction, our findings could suggest disturbed WM maturation in UHR individuals.
AB - OBJECTIVE: The neurodevelopmental hypothesis of psychosis suggests that disrupted white matter (WM) maturation underlies disease onset. In this longitudinal study, we investigated WM connectivity and compared WM changes between individuals at ultra-high-risk for psychosis (UHR) and healthy controls (HCs).METHOD: Thirty UHR individuals and 23 HCs underwent MR diffusion tensor imaging before and after 12 months of non-manualized standard care. Positive and negative symptoms and level of functioning were assessed. Tract-based spatial statistics were employed.RESULTS: During 12 months, none of the UHR individuals transitioned to psychosis. Both UHR individuals and HCs increased significantly in fractional anisotropy (FA). UHR individuals showed significant FA increases predominantly in the left superior longitudinal fasciculus (SLF) (P = 0.01), and HCs showed significant FA increases in the left uncinate fasciculus (P = 0.03). Within UHR individuals, a significant positive correlation between FA change and age was observed predominantly in the left SLF (P = 0.02). Within HCs, no significant correlation between FA change and age was observed. No significant correlations between baseline FA and clinical outcomes were observed; however, FA changes were significantly positively correlated to changes in negative symptoms (P = 0.04).CONCLUSION: As normal brain maturation occurs in a posterior to frontal direction, our findings could suggest disturbed WM maturation in UHR individuals.
KW - Adolescent
KW - Adult
KW - Anisotropy
KW - Brain/diagnostic imaging
KW - Case-Control Studies
KW - Diffusion Tensor Imaging
KW - Female
KW - Humans
KW - Longitudinal Studies
KW - Magnetic Resonance Imaging
KW - Male
KW - Prodromal Symptoms
KW - Psychotic Disorders/diagnostic imaging
KW - Risk
KW - White Matter/diagnostic imaging
KW - Young Adult
U2 - 10.1111/acps.12835
DO - 10.1111/acps.12835
M3 - Journal article
C2 - 29143980
VL - 137
SP - 65
EP - 78
JO - Acta Psychiatrica Scandinavica
JF - Acta Psychiatrica Scandinavica
SN - 0001-690X
IS - 1
ER -
ID: 215410404