Vitamin C pharmacokinetics*
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
The absorption, distribution, and retention of vitamin C are primarily governed by the family of sodium-dependent vitamin C transporters (SVCTs). The diverse expression and concentration dependency of these transporters throughout the body have resulted in the highly complex, compartmentalized, and nonlinear pharmacokinetics of vitamin C at physiologic levels. Moreover, studies of human SVCTs have identified a number of polymorphisms and suggested that these may have significant impact on the pharmacokinetics of vitamin C. In addition to its many biological functions, the putative effect of vitamin C in cancer treatment has been the subject of much debate. However, following the critical realization that oral administration of vitamin C profoundly limits the maximum achievable plasma concentration, vitamin C is currently being reinvestigated for its specific toxicity to cancer cells at high concentrations only achievable by intravenous infusion. Here, the pharmacokinetics of vitamin C appears to change from zero to first order, displaying a constant and dose-independent half-life. The present chapter examines the pharmacokinetics of vitamin C under various conditions and discusses its implications for vitamin C homeostasis.
Original language | English |
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Title of host publication | Vitamin C : New Biochemical and Functional Insights |
Number of pages | 16 |
Publisher | CRC Press |
Publication date | 1 Jan 2020 |
Pages | 55-70 |
ISBN (Print) | 9781138337992 |
ISBN (Electronic) | 9780429807817 |
DOIs | |
Publication status | Published - 1 Jan 2020 |
Bibliographical note
Publisher Copyright:
© 2020 by Taylor & Francis Group, LLC.
ID: 390396114