Virulence Factors for Hemolytic Uremic Syndrome, Denmark
Research output: Contribution to journal › Journal article › Research › peer-review
We present an analysis of strain and patient factors associated with the development of bloody diarrhea and hemolytic uremic syndrome (HUS) among Shiga toxin-producing Escherichia coli (STEC) patients registered in Denmark in a 6-year period. Of 343 STEC patients, bloody diarrhea developed in 36.4% and HUS in 6.1%. In a multivariate logistic regression model, risk factors for bloody diarrhea were the eae and stx2 genes, O groups 0157 and O103, and increasing age. Risk factors for HUS were presence of the stx2 (odds ratio [OR] 18.9) and eae (OR undefined) genes, being a child, and having bloody diarrhea. O group O157, although associated with HUS in a univariate analysis (OR 4.0), was not associated in the multivariate analysis (OR 1.1). This finding indicates that, rather than the O group, the combined presence of the eae and stx2 genes is an important predictor of HUS.
Original language | English |
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Journal | Emerging Infectious Diseases |
Volume | 10 |
Issue number | 5 |
Pages (from-to) | 842-847 |
Number of pages | 6 |
ISSN | 1080-6040 |
DOIs | |
Publication status | Published - 1 Jan 2004 |
ID: 203887662