Urinary fluoride excretion after application of fluoride varnish and use of fluoride toothpaste in young children
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Urinary fluoride excretion after application of fluoride varnish and use of fluoride toothpaste in young children. / Lockner, Frida; Twetman, Svante; Stecksén-Blicks, Christina.
In: International Journal of Paediatric Dentistry, Vol. 27, No. 6, 11.2017, p. 463-468.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Urinary fluoride excretion after application of fluoride varnish and use of fluoride toothpaste in young children
AU - Lockner, Frida
AU - Twetman, Svante
AU - Stecksén-Blicks, Christina
N1 - © 2017 BSPD, IAPD and John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
PY - 2017/11
Y1 - 2017/11
N2 - BACKGROUND: The efficacy and safety of combined use of topical fluoride products are essential issues that must be monitored.AIM: To assess urinary excretion of fluoride after application of two different dental varnishes containing 2.26% fluoride in 3- to 4-year-old children and to compare the levels with and without parallel use of fluoride toothpaste.DESIGN: Fifteen healthy children were enrolled to a randomized crossover trial that was performed in two parts: Part I with twice-daily tooth brushing with fluoride toothpaste and Part II with twice-daily brushing with a non-fluoride toothpaste. After a 1-week run-in period, 0.1 mL of the two fluoride varnishes (Duraphat and Profluorid Varnish) was topically applied in a randomized order. Baseline and experimental urine was collected during 6-h periods. The fluoride content was determined with an ion-sensitive electrode.RESULTS: There was a statistically significant increase in the 6-h fluoride excretion after application of both experimental varnishes, with and without parallel use of fluoride toothpaste (P < 0.01). When fluoridated toothpaste was used, the mean fluoride excretion was 0.20 mg/6 h after application of Duraphat and 0.29 mg/6 h after application of Profluorid Varnish (P = 0.18).CONCLUSIONS: Topical applications of 0.1 mL of fluoride varnish significantly increased the 6-h fluoride excretion. As some individuals displayed excretion levels exceeding the optimal fluoride exposure, a restricted use of fluoride toothpaste in connection with the varnish applications would decrease fluoride exposure.
AB - BACKGROUND: The efficacy and safety of combined use of topical fluoride products are essential issues that must be monitored.AIM: To assess urinary excretion of fluoride after application of two different dental varnishes containing 2.26% fluoride in 3- to 4-year-old children and to compare the levels with and without parallel use of fluoride toothpaste.DESIGN: Fifteen healthy children were enrolled to a randomized crossover trial that was performed in two parts: Part I with twice-daily tooth brushing with fluoride toothpaste and Part II with twice-daily brushing with a non-fluoride toothpaste. After a 1-week run-in period, 0.1 mL of the two fluoride varnishes (Duraphat and Profluorid Varnish) was topically applied in a randomized order. Baseline and experimental urine was collected during 6-h periods. The fluoride content was determined with an ion-sensitive electrode.RESULTS: There was a statistically significant increase in the 6-h fluoride excretion after application of both experimental varnishes, with and without parallel use of fluoride toothpaste (P < 0.01). When fluoridated toothpaste was used, the mean fluoride excretion was 0.20 mg/6 h after application of Duraphat and 0.29 mg/6 h after application of Profluorid Varnish (P = 0.18).CONCLUSIONS: Topical applications of 0.1 mL of fluoride varnish significantly increased the 6-h fluoride excretion. As some individuals displayed excretion levels exceeding the optimal fluoride exposure, a restricted use of fluoride toothpaste in connection with the varnish applications would decrease fluoride exposure.
U2 - 10.1111/ipd.12284
DO - 10.1111/ipd.12284
M3 - Journal article
C2 - 28105705
VL - 27
SP - 463
EP - 468
JO - International Journal of Paediatric Dentistry
JF - International Journal of Paediatric Dentistry
SN - 0960-7439
IS - 6
ER -
ID: 173155775