Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity
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- Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity
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Infection with Plasmodium can elicit antibodies that inhibit parasite survival in the mosquito, when they are ingested in an infectious blood meal. Here, we determine the transmission-reducing activity (TRA) of naturally acquired antibodies from 648 malaria-exposed individuals using lab-based mosquito-feeding assays. Transmission inhibition is significantly associated with antibody responses to Pfs48/45, Pfs230, and to 43 novel gametocyte proteins assessed by protein microarray. In field-based mosquito-feeding assays the likelihood and rate of mosquito infection are significantly lower for individuals reactive to Pfs48/45, Pfs230 or to combinations of the novel TRA-associated proteins. We also show that naturally acquired purified antibodies against key transmission-blocking epitopes of Pfs48/45 and Pfs230 are mechanistically involved in TRA, whereas sera depleted of these antibodies retain high-level, complement-independent TRA. Our analysis demonstrates that host antibody responses to gametocyte proteins are associated with reduced malaria transmission efficiency from humans to mosquitoes.
Original language | English |
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Article number | 558 |
Journal | Nature Communications |
Volume | 9 |
Issue number | 1 |
Number of pages | 14 |
ISSN | 2041-1723 |
DOIs | |
Publication status | Published - 8 Feb 2018 |
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