Unique splicing pattern of the TCF7L2 gene in human pancreatic islets
Research output: Contribution to journal › Journal article › Research › peer-review
Intronic variation in the TCF7L2 gene exhibits the strongest association to type 2 diabetes observed to date, but the mechanism whereby this genetic variation translates into altered biological function is largely unknown. A possible explanation is a genotype-dependent difference in the complex splicing pattern; however, this has not previously been characterised in pancreatic or insulin target tissues. Here, the detailed TCF7L2 splicing pattern in five human tissues is described and dependence on risk genotype explored.
Original language | English |
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Journal | Diabetologia |
Volume | 52 |
Issue number | 5 |
Pages (from-to) | 850-4 |
Number of pages | 5 |
ISSN | 0012-186X |
DOIs | |
Publication status | Published - May 2009 |
- Adipose Tissue, Adult, Aged, Alternative Splicing, Cadaver, Diabetes Mellitus, Type 2, Exons, Female, Genetic Variation, Humans, Islets of Langerhans, Lymphocytes, Male, Middle Aged, Muscle, Skeletal, RNA, Reference Values, Reverse Transcriptase Polymerase Chain Reaction, TCF Transcription Factors, Tissue Donors, Transcription Factor 7-Like 2 Protein, Transcription, Genetic
Research areas
ID: 46404471