Umpolung Reactivity of Aldehydes toward Carbon Dioxide
Research output: Contribution to journal › Journal article › Research › peer-review
Abstract Carbon dioxide is an intrinsically stable molecule. Therefore, its activation requires extra energy input in the form of reactive reagents and/or activated catalysts and, often, harsh reaction conditions. Reported here is a direct carboxylation reaction of aromatic aldehydes with carbon dioxide to afford α-keto acids as added-value products. In situ generation of a reactive cyanohydrin was the key to the successful carboxylation reaction under operationally mild reaction conditions (25?40?°C, 1?atm CO2). The resulting α-keto acids served as a platform for α-amino acid synthesis by reductive amination reactions, illustrating the chemical synthesis of essential bioactive molecules from carbon dioxide.
Original language | English |
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Journal | Angewandte Chemie International Edition |
Volume | 57 |
Issue number | 38 |
Pages (from-to) | 12318-12322 |
Number of pages | 5 |
ISSN | 1433-7851 |
DOIs | |
Publication status | Published - 17 Sep 2018 |
Bibliographical note
doi: 10.1002/anie.201806569
- amino acids, carbon dioxide fixation, carboxylation, reaction mechanisms, umpolung
Research areas
ID: 202235524