Two-year follow-up survey of patients with allergic contact dermatitis from an occupational cohort: is the prognosis dependent on the omnipresence of the allergen?
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Two-year follow-up survey of patients with allergic contact dermatitis from an occupational cohort : is the prognosis dependent on the omnipresence of the allergen? / Clemmensen, Kim Katrine Bjerring; Carøe, T K; Thomsen, S F; Ebbehøj, N E; Agner, T.
In: British Journal of Dermatology, Vol. 170, No. 5, 2014, p. 1100-1105.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Two-year follow-up survey of patients with allergic contact dermatitis from an occupational cohort
T2 - is the prognosis dependent on the omnipresence of the allergen?
AU - Clemmensen, Kim Katrine Bjerring
AU - Carøe, T K
AU - Thomsen, S F
AU - Ebbehøj, N E
AU - Agner, T
N1 - © 2013 British Association of Dermatologists.
PY - 2014
Y1 - 2014
N2 - BACKGROUND: Skin diseases are the most frequently recognized occupational diseases in Denmark. The prognosis for occupational contact dermatitis is often poor.OBJECTIVES: To investigate the prognosis, assessed by eczema, job status and skin-related quality of life, among patients allergic to rubber chemicals and latex (ubiquitous allergens) and epoxy (nonubiquitous allergen), 2 years after recognition of occupational allergic contact dermatitis.METHODS: From a cohort of all patients recognized as having occupational dermatitis by the Danish National Board of Industrial Injuries in 2010, 199 patients with relevant rubber allergy (contact allergy to rubber chemicals or contact urticaria from latex) or epoxy allergy were identified. Follow-up consisted of a questionnaire covering current severity of eczema, employment, exposure and quality of life.RESULTS: The response rate was 75%. Clearance of eczema was reported by 11% of patients and 67% reported improvement. Overall 22% of patients with allergy to a nonubiquitous allergen had total clearance of eczema compared with 10% of cases allergic to ubiquitous allergens and 0% of those with contact urticaria (P = 0·116). Improvement was significantly more frequent in those who had changed jobs compared with those who had not (P = 0·01).CONCLUSIONS: At follow-up, patients with contact urticaria had significantly poorer prognosis than those with contact allergy, and there was a trend towards a poorer prognosis for those with contact allergy to rubber chemicals than those with allergy to epoxy. A significant positive association between job change and improvement was found.
AB - BACKGROUND: Skin diseases are the most frequently recognized occupational diseases in Denmark. The prognosis for occupational contact dermatitis is often poor.OBJECTIVES: To investigate the prognosis, assessed by eczema, job status and skin-related quality of life, among patients allergic to rubber chemicals and latex (ubiquitous allergens) and epoxy (nonubiquitous allergen), 2 years after recognition of occupational allergic contact dermatitis.METHODS: From a cohort of all patients recognized as having occupational dermatitis by the Danish National Board of Industrial Injuries in 2010, 199 patients with relevant rubber allergy (contact allergy to rubber chemicals or contact urticaria from latex) or epoxy allergy were identified. Follow-up consisted of a questionnaire covering current severity of eczema, employment, exposure and quality of life.RESULTS: The response rate was 75%. Clearance of eczema was reported by 11% of patients and 67% reported improvement. Overall 22% of patients with allergy to a nonubiquitous allergen had total clearance of eczema compared with 10% of cases allergic to ubiquitous allergens and 0% of those with contact urticaria (P = 0·116). Improvement was significantly more frequent in those who had changed jobs compared with those who had not (P = 0·01).CONCLUSIONS: At follow-up, patients with contact urticaria had significantly poorer prognosis than those with contact allergy, and there was a trend towards a poorer prognosis for those with contact allergy to rubber chemicals than those with allergy to epoxy. A significant positive association between job change and improvement was found.
KW - Adolescent
KW - Adult
KW - Aged
KW - Allergens
KW - Denmark
KW - Dermatitis, Allergic Contact
KW - Dermatitis, Occupational
KW - Eczema
KW - Employment
KW - Female
KW - Follow-Up Studies
KW - Humans
KW - Latex Hypersensitivity
KW - Male
KW - Middle Aged
KW - Prognosis
KW - Quality of Life
KW - Urticaria
KW - Young Adult
U2 - 10.1111/bjd.12795
DO - 10.1111/bjd.12795
M3 - Journal article
C2 - 24359102
VL - 170
SP - 1100
EP - 1105
JO - British Journal of Dermatology
JF - British Journal of Dermatology
SN - 0007-0963
IS - 5
ER -
ID: 138284701