Tumor-tracking radiotherapy of moving targets; verification using 3D polymer gel, 2D ion-chamber array and biplanar diode array
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Tumor-tracking radiotherapy of moving targets; verification using 3D polymer gel, 2D ion-chamber array and biplanar diode array. / Ceberg, Sofie; Falk, Marianne; Af Rosenschöld, Per Munck; Cattell, Herbert; Gustafsson, Helen; Keall, Paul; Korreman, Stine S.; Medin, Joakim; Nordström, Fredrik; Persson, Gitte; Sawant, Amit; Svatos, Michelle; Zimmerman, Jens; Bäck, Sven Å J.
In: Journal of Physics: Conference Series, Vol. 250, 012051, 2010, p. 235-239.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Tumor-tracking radiotherapy of moving targets; verification using 3D polymer gel, 2D ion-chamber array and biplanar diode array
AU - Ceberg, Sofie
AU - Falk, Marianne
AU - Af Rosenschöld, Per Munck
AU - Cattell, Herbert
AU - Gustafsson, Helen
AU - Keall, Paul
AU - Korreman, Stine S.
AU - Medin, Joakim
AU - Nordström, Fredrik
AU - Persson, Gitte
AU - Sawant, Amit
AU - Svatos, Michelle
AU - Zimmerman, Jens
AU - Bäck, Sven Å J.
PY - 2010
Y1 - 2010
N2 - The aim of this study was to carry out a dosimetric verification of a dynamic multileaf collimator (DMLC)-based tumor-tracking delivery during respiratory-like motion. The advantage of tumor-tracking radiation delivery is the ability to allow a tighter margin around the target by continuously following and adapting the dose delivery to its motion. However, there are geometric and dosimetric uncertainties associated with beam delivery system constraints and output variations, and several investigations have to be accomplished before a clinical integration of this tracking technique. Two types of delivery were investigated in this study I) a single beam perpendicular to a target with a one dimensional motion parallel to the MLC moving direction, and II) an intensity modulated arc delivery (RapidArc®) with a target motion diagonal to the MLC moving direction. The feasibility study (I) was made using an 2D ionisation chamber array and a true 3D polymer gel. The arc delivery (II) was verified using polymer gel and a biplanar diode array. Good agreement in absorbed dose was found between delivery to a static target and to a moving target with DMLC tracking using all three detector systems. However, due to the limited spatial resolution of the 2D array a detailed comparison was not possible. The RapidArc® plan delivery was successfully verified using the biplanar diode array and true 3D polymer gel, and both detector systems could verify that the DMLC-based tumor-tracking delivery system has a very good ability to account for respiratory target motion.
AB - The aim of this study was to carry out a dosimetric verification of a dynamic multileaf collimator (DMLC)-based tumor-tracking delivery during respiratory-like motion. The advantage of tumor-tracking radiation delivery is the ability to allow a tighter margin around the target by continuously following and adapting the dose delivery to its motion. However, there are geometric and dosimetric uncertainties associated with beam delivery system constraints and output variations, and several investigations have to be accomplished before a clinical integration of this tracking technique. Two types of delivery were investigated in this study I) a single beam perpendicular to a target with a one dimensional motion parallel to the MLC moving direction, and II) an intensity modulated arc delivery (RapidArc®) with a target motion diagonal to the MLC moving direction. The feasibility study (I) was made using an 2D ionisation chamber array and a true 3D polymer gel. The arc delivery (II) was verified using polymer gel and a biplanar diode array. Good agreement in absorbed dose was found between delivery to a static target and to a moving target with DMLC tracking using all three detector systems. However, due to the limited spatial resolution of the 2D array a detailed comparison was not possible. The RapidArc® plan delivery was successfully verified using the biplanar diode array and true 3D polymer gel, and both detector systems could verify that the DMLC-based tumor-tracking delivery system has a very good ability to account for respiratory target motion.
UR - http://www.scopus.com/inward/record.url?scp=78650584020&partnerID=8YFLogxK
U2 - 10.1088/1742-6596/250/1/012051
DO - 10.1088/1742-6596/250/1/012051
M3 - Journal article
AN - SCOPUS:78650584020
VL - 250
SP - 235
EP - 239
JO - Journal of Physics: Conference Series
JF - Journal of Physics: Conference Series
SN - 1742-6588
M1 - 012051
ER -
ID: 357333171