Trigeminal ganglion neurons are directly activated by influx of CSF solutes in a migraine model

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Trigeminal ganglion neurons are directly activated by influx of CSF solutes in a migraine model. / Kaag Rasmussen, Martin; Møllgård, Kjeld; Bork, Peter A R; Weikop, Pia; Esmail, Tina; Drici, Lylia; Wewer Albrechtsen, Nicolai J; Carlsen, Jonathan Frederik; Huynh, Nguyen P T; Ghitani, Nima; Mann, Matthias; Goldman, Steven A; Mori, Yuki; Chesler, Alexander T; Nedergaard, Maiken.

In: Science (New York, N.Y.), Vol. 385, No. 6704, 2024, p. 80-86.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kaag Rasmussen, M, Møllgård, K, Bork, PAR, Weikop, P, Esmail, T, Drici, L, Wewer Albrechtsen, NJ, Carlsen, JF, Huynh, NPT, Ghitani, N, Mann, M, Goldman, SA, Mori, Y, Chesler, AT & Nedergaard, M 2024, 'Trigeminal ganglion neurons are directly activated by influx of CSF solutes in a migraine model', Science (New York, N.Y.), vol. 385, no. 6704, pp. 80-86. https://doi.org/10.1126/science.adl0544

APA

Kaag Rasmussen, M., Møllgård, K., Bork, P. A. R., Weikop, P., Esmail, T., Drici, L., Wewer Albrechtsen, N. J., Carlsen, J. F., Huynh, N. P. T., Ghitani, N., Mann, M., Goldman, S. A., Mori, Y., Chesler, A. T., & Nedergaard, M. (2024). Trigeminal ganglion neurons are directly activated by influx of CSF solutes in a migraine model. Science (New York, N.Y.), 385(6704), 80-86. https://doi.org/10.1126/science.adl0544

Vancouver

Kaag Rasmussen M, Møllgård K, Bork PAR, Weikop P, Esmail T, Drici L et al. Trigeminal ganglion neurons are directly activated by influx of CSF solutes in a migraine model. Science (New York, N.Y.). 2024;385(6704):80-86. https://doi.org/10.1126/science.adl0544

Author

Kaag Rasmussen, Martin ; Møllgård, Kjeld ; Bork, Peter A R ; Weikop, Pia ; Esmail, Tina ; Drici, Lylia ; Wewer Albrechtsen, Nicolai J ; Carlsen, Jonathan Frederik ; Huynh, Nguyen P T ; Ghitani, Nima ; Mann, Matthias ; Goldman, Steven A ; Mori, Yuki ; Chesler, Alexander T ; Nedergaard, Maiken. / Trigeminal ganglion neurons are directly activated by influx of CSF solutes in a migraine model. In: Science (New York, N.Y.). 2024 ; Vol. 385, No. 6704. pp. 80-86.

Bibtex

@article{88abc1d013c24d4a8cb86babae63da64,
title = "Trigeminal ganglion neurons are directly activated by influx of CSF solutes in a migraine model",
abstract = "Classical migraine patients experience aura, which is transient neurological deficits associated with cortical spreading depression (CSD), preceding headache attacks. It is not currently understood how a pathological event in cortex can affect peripheral sensory neurons. In this study, we show that cerebrospinal fluid (CSF) flows into the trigeminal ganglion, establishing nonsynaptic signaling between brain and trigeminal cells. After CSD, ~11% of the CSF proteome is altered, with up-regulation of proteins that directly activate receptors in the trigeminal ganglion. CSF collected from animals exposed to CSD activates trigeminal neurons in na{\"i}ve mice in part by CSF-borne calcitonin gene-related peptide (CGRP). We identify a communication pathway between the central and peripheral nervous system that might explain the relationship between migrainous aura and headache.",
keywords = "Animals, Mice, Calcitonin Gene-Related Peptide/cerebrospinal fluid, Cerebrospinal Fluid/metabolism, Cortical Spreading Depression, Disease Models, Animal, Migraine Disorders/cerebrospinal fluid, Proteome/metabolism, Signal Transduction, Trigeminal Ganglion/metabolism",
author = "{Kaag Rasmussen}, Martin and Kjeld M{\o}llg{\aa}rd and Bork, {Peter A R} and Pia Weikop and Tina Esmail and Lylia Drici and {Wewer Albrechtsen}, {Nicolai J} and Carlsen, {Jonathan Frederik} and Huynh, {Nguyen P T} and Nima Ghitani and Matthias Mann and Goldman, {Steven A} and Yuki Mori and Chesler, {Alexander T} and Maiken Nedergaard",
year = "2024",
doi = "10.1126/science.adl0544",
language = "English",
volume = "385",
pages = "80--86",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6704",

}

RIS

TY - JOUR

T1 - Trigeminal ganglion neurons are directly activated by influx of CSF solutes in a migraine model

AU - Kaag Rasmussen, Martin

AU - Møllgård, Kjeld

AU - Bork, Peter A R

AU - Weikop, Pia

AU - Esmail, Tina

AU - Drici, Lylia

AU - Wewer Albrechtsen, Nicolai J

AU - Carlsen, Jonathan Frederik

AU - Huynh, Nguyen P T

AU - Ghitani, Nima

AU - Mann, Matthias

AU - Goldman, Steven A

AU - Mori, Yuki

AU - Chesler, Alexander T

AU - Nedergaard, Maiken

PY - 2024

Y1 - 2024

N2 - Classical migraine patients experience aura, which is transient neurological deficits associated with cortical spreading depression (CSD), preceding headache attacks. It is not currently understood how a pathological event in cortex can affect peripheral sensory neurons. In this study, we show that cerebrospinal fluid (CSF) flows into the trigeminal ganglion, establishing nonsynaptic signaling between brain and trigeminal cells. After CSD, ~11% of the CSF proteome is altered, with up-regulation of proteins that directly activate receptors in the trigeminal ganglion. CSF collected from animals exposed to CSD activates trigeminal neurons in naïve mice in part by CSF-borne calcitonin gene-related peptide (CGRP). We identify a communication pathway between the central and peripheral nervous system that might explain the relationship between migrainous aura and headache.

AB - Classical migraine patients experience aura, which is transient neurological deficits associated with cortical spreading depression (CSD), preceding headache attacks. It is not currently understood how a pathological event in cortex can affect peripheral sensory neurons. In this study, we show that cerebrospinal fluid (CSF) flows into the trigeminal ganglion, establishing nonsynaptic signaling between brain and trigeminal cells. After CSD, ~11% of the CSF proteome is altered, with up-regulation of proteins that directly activate receptors in the trigeminal ganglion. CSF collected from animals exposed to CSD activates trigeminal neurons in naïve mice in part by CSF-borne calcitonin gene-related peptide (CGRP). We identify a communication pathway between the central and peripheral nervous system that might explain the relationship between migrainous aura and headache.

KW - Animals

KW - Mice

KW - Calcitonin Gene-Related Peptide/cerebrospinal fluid

KW - Cerebrospinal Fluid/metabolism

KW - Cortical Spreading Depression

KW - Disease Models, Animal

KW - Migraine Disorders/cerebrospinal fluid

KW - Proteome/metabolism

KW - Signal Transduction

KW - Trigeminal Ganglion/metabolism

U2 - 10.1126/science.adl0544

DO - 10.1126/science.adl0544

M3 - Journal article

C2 - 38963846

VL - 385

SP - 80

EP - 86

JO - Science

JF - Science

SN - 0036-8075

IS - 6704

ER -

ID: 397721692