Towards nutrition with precision: unlocking biomarkers as dietary assessment tools
Research output: Contribution to journal › Review › Research › peer-review
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Towards nutrition with precision : unlocking biomarkers as dietary assessment tools. / Cuparencu, Cătălina; Bulmuş-Tüccar, Tuğçe; Stanstrup, Jan; La Barbera, Giorgia; Roager, Henrik M.; Dragsted, Lars O.
In: Nature Metabolism, 2024.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Towards nutrition with precision
T2 - unlocking biomarkers as dietary assessment tools
AU - Cuparencu, Cătălina
AU - Bulmuş-Tüccar, Tuğçe
AU - Stanstrup, Jan
AU - La Barbera, Giorgia
AU - Roager, Henrik M.
AU - Dragsted, Lars O.
N1 - Publisher Copyright: © Springer Nature Limited 2024.
PY - 2024
Y1 - 2024
N2 - Precision nutrition requires precise tools to monitor dietary habits. Yet current dietary assessment instruments are subjective, limiting our understanding of the causal relationships between diet and health. Biomarkers of food intake (BFIs) hold promise to increase the objectivity and accuracy of dietary assessment, enabling adjustment for compliance and misreporting. Here, we update current concepts and provide a comprehensive overview of BFIs measured in urine and blood. We rank BFIs based on a four-level utility scale to guide selection and identify combinations of BFIs that specifically reflect complex food intakes, making them applicable as dietary instruments. We discuss the main challenges in biomarker development and illustrate key solutions for the application of BFIs in human studies, highlighting different strategies for selecting and combining BFIs to support specific study designs. Finally, we present a roadmap for BFI development and implementation to leverage current knowledge and enable precision in nutrition research.
AB - Precision nutrition requires precise tools to monitor dietary habits. Yet current dietary assessment instruments are subjective, limiting our understanding of the causal relationships between diet and health. Biomarkers of food intake (BFIs) hold promise to increase the objectivity and accuracy of dietary assessment, enabling adjustment for compliance and misreporting. Here, we update current concepts and provide a comprehensive overview of BFIs measured in urine and blood. We rank BFIs based on a four-level utility scale to guide selection and identify combinations of BFIs that specifically reflect complex food intakes, making them applicable as dietary instruments. We discuss the main challenges in biomarker development and illustrate key solutions for the application of BFIs in human studies, highlighting different strategies for selecting and combining BFIs to support specific study designs. Finally, we present a roadmap for BFI development and implementation to leverage current knowledge and enable precision in nutrition research.
U2 - 10.1038/s42255-024-01067-y
DO - 10.1038/s42255-024-01067-y
M3 - Review
C2 - 38956322
AN - SCOPUS:85197469245
JO - Nature Metabolism
JF - Nature Metabolism
SN - 2522-5812
ER -
ID: 398062226