There Is No Association Between the Circadian Clock Gene HPER3 and Cognitive Dysfunction After Noncardiac Surgery
Research output: Contribution to journal › Journal article › Research › peer-review
The specific clock-gene PERIOD3 is important with regard to circadian rhythmicity, sleep homeostasis, and cognitive function. The allele PER3(5/5) has been associated with worse cognitive performance in response to sleep deprivation. We hypothesized that patients with the PER3(5/5) genotype would have an increased risk of postoperative cognitive dysfunction (POCD) 1 week after noncardiac surgery.
| Original language | English |
|---|---|
| Journal | Anesthesia and Analgesia |
| Volume | 115 |
| Issue number | 2 |
| Pages (from-to) | 379-85 |
| Number of pages | 7 |
| ISSN | 0003-2999 |
| DOIs | |
| Publication status | Published - 2012 |
ID: 40191116