Therapeutic application of multipotent stem cells
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Therapeutic application of multipotent stem cells. / Mirzaei, Hamed; Sahebkar, Amirhossein; Sichani, Laleh Shiri; Moridikia, Abdullah; Nazari, Sara; Sadri Nahand, Javid; salehi, Hossein; Stenvang, Jan; Masoudifar, Aria; Mirzaei, Hamid R.; Jaafari, Mahmoud R.
In: Journal of Cellular Physiology, Vol. 233, No. 4, 2018, p. 2815–2823.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Therapeutic application of multipotent stem cells
AU - Mirzaei, Hamed
AU - Sahebkar, Amirhossein
AU - Sichani, Laleh Shiri
AU - Moridikia, Abdullah
AU - Nazari, Sara
AU - Sadri Nahand, Javid
AU - salehi, Hossein
AU - Stenvang, Jan
AU - Masoudifar, Aria
AU - Mirzaei, Hamid R.
AU - Jaafari, Mahmoud R.
PY - 2018
Y1 - 2018
N2 - Cell therapy is an emerging fields in the treatment of various diseases such as cardiovascular, pulmonary, hepatic, and neoplastic diseases. Stem cells are an integral tool for cell therapy. Multipotent stem cells are an important class of stem cells which have the ability to self-renew through dividing and developing into multiple specific cell types in a specific tissue or organ. These cells are capable to activate or inhibit a sequence of cellular and molecular pathways leading to anti-inflammatory and anti-apoptotic effects which might contribute to the treatment of various diseases. It has been showed that multipotent stem cells exert their therapeutic effects via inhibition/activation of a sequence of cellular and molecular pathways. Although the advantages of multipotent stem cells are numerous, further investigation is still necessary to clarify the biology and safety of these cells before they could be considered as a potential treatment for different types of diseases. This review summarizes different features of multipotent stem cells including isolation, differentiation, and therapeutic applications.
AB - Cell therapy is an emerging fields in the treatment of various diseases such as cardiovascular, pulmonary, hepatic, and neoplastic diseases. Stem cells are an integral tool for cell therapy. Multipotent stem cells are an important class of stem cells which have the ability to self-renew through dividing and developing into multiple specific cell types in a specific tissue or organ. These cells are capable to activate or inhibit a sequence of cellular and molecular pathways leading to anti-inflammatory and anti-apoptotic effects which might contribute to the treatment of various diseases. It has been showed that multipotent stem cells exert their therapeutic effects via inhibition/activation of a sequence of cellular and molecular pathways. Although the advantages of multipotent stem cells are numerous, further investigation is still necessary to clarify the biology and safety of these cells before they could be considered as a potential treatment for different types of diseases. This review summarizes different features of multipotent stem cells including isolation, differentiation, and therapeutic applications.
KW - Differentiation
KW - Multipotent stem cells
KW - Therapy
U2 - 10.1002/jcp.25990
DO - 10.1002/jcp.25990
M3 - Review
C2 - 28475219
AN - SCOPUS:85021227833
VL - 233
SP - 2815
EP - 2823
JO - Journal of Cellular Physiology
JF - Journal of Cellular Physiology
SN - 0021-9541
IS - 4
ER -
ID: 188481907