The use of combined heart rate response and accelerometry to assess the level and predictors of physical activity in tuberculosis patients in Tanzania
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The use of combined heart rate response and accelerometry to assess the level and predictors of physical activity in tuberculosis patients in Tanzania. / Faurholt-Jepsen, Maria; Faurholt-Jepsen, Daniel; Range, N; Praygod, G; Jeremiah, K; Aabye, M G; Changalucha, J; Krarup, H; Christensen, Dirk Lund; Andersen, A B; Brage, Søren; Friis, Henrik.
In: Epidemiology and Infection, Vol. 142, No. 6, 2014, p. 1334-1342.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The use of combined heart rate response and accelerometry to assess the level and predictors of physical activity in tuberculosis patients in Tanzania
AU - Faurholt-Jepsen, Maria
AU - Faurholt-Jepsen, Daniel
AU - Range, N
AU - Praygod, G
AU - Jeremiah, K
AU - Aabye, M G
AU - Changalucha, J
AU - Krarup, H
AU - Christensen, Dirk Lund
AU - Andersen, A B
AU - Brage, Søren
AU - Friis, Henrik
N1 - CURIS 2014 NEXS 218
PY - 2014
Y1 - 2014
N2 - SUMMARY: We assessed the role of tuberculosis (TB) disease and HIV infection on the level of physical activity. A combined heart rate and movement sensor was used to assess habitual physical activity in TB patients and non-TB controls. The association between sputum-negative TB, sputum-positive TB, HIV and physical activity estimates were assessed in multivariable linear regression models adjusted for age, sex, haemoglobin and alpha-1-acid glycoprotein (AGP). Sputum-positive [eB 0·43, 95% confidence interval (CI) 0·29-0·64] and sputum-negative (eB 0·67, 95% CI 0·47-0·94) TB as well as HIV infection (eB 0·59, 95% CI 0·46-0·75) were associated with reduced activity compared to controls. Anaemia accounted for a substantial part of the effects of HIV, while elevated AGP primarily mediated the TB effect. The level of physical activity is highly influenced by TB and HIV, and mainly mediated through anaemia of infection and associated with elevated acute phase response.
AB - SUMMARY: We assessed the role of tuberculosis (TB) disease and HIV infection on the level of physical activity. A combined heart rate and movement sensor was used to assess habitual physical activity in TB patients and non-TB controls. The association between sputum-negative TB, sputum-positive TB, HIV and physical activity estimates were assessed in multivariable linear regression models adjusted for age, sex, haemoglobin and alpha-1-acid glycoprotein (AGP). Sputum-positive [eB 0·43, 95% confidence interval (CI) 0·29-0·64] and sputum-negative (eB 0·67, 95% CI 0·47-0·94) TB as well as HIV infection (eB 0·59, 95% CI 0·46-0·75) were associated with reduced activity compared to controls. Anaemia accounted for a substantial part of the effects of HIV, while elevated AGP primarily mediated the TB effect. The level of physical activity is highly influenced by TB and HIV, and mainly mediated through anaemia of infection and associated with elevated acute phase response.
KW - Accelerometry
KW - Adult
KW - Female
KW - Heart Rate
KW - Humans
KW - Male
KW - Monitoring, Physiologic
KW - Motor Activity
KW - Tanzania
KW - Tuberculosis
U2 - 10.1017/S0950268813002070
DO - 10.1017/S0950268813002070
M3 - Journal article
C2 - 24007696
VL - 142
SP - 1334
EP - 1342
JO - Epidemiology and Infection
JF - Epidemiology and Infection
SN - 0950-2688
IS - 6
ER -
ID: 120025418