The spatial distribution of otosclerosis: a quantitative study using design-based stereology
Research output: Contribution to journal › Journal article › Research › peer-review
This study documents that otosclerotic bone remodeling is distributed centripetally around the inner ear space whereas normal bone remodeling is distributed centrifugally. We suggest that this inverse relation reflects the unique osteo-dynamic setting of the otic capsule: since perilabyrinthine bone remodeling is extremely low, osteocyte deficiency and microcracks accumulate in excess toward the inner ear space with age. This may disrupt the osseus functional network, impede propagation of anti-resorptive signals, and precipitate otosclerotic bone remodeling with a spatial preference for older bone.
Original language | English |
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Journal | Acta Oto-Laryngologica |
Volume | 130 |
Issue number | 5 |
Pages (from-to) | 532-9 |
Number of pages | 8 |
ISSN | 0001-6489 |
DOIs | |
Publication status | Published - 1 May 2010 |
ID: 34055730