The significance of mitochondrial haplogroups in preeclampsia risk
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Objective: To determine whether mitochondrial haplogroups function as disease-modifiers or as susceptibility factors in preeclampsia using a traditional haplogroup association model. Methods: This retrospective study haplotyped 235 control and 78 preeclamptic pregnancies from Denmark using either real-time PCR or Sanger sequencing depending on the rarity of the haplogroup. Results: No significant association between haplogroups and the risk of preeclampsia was found, nor was any role for haplogroups in disease severity uncovered. Conclusion: Mitochondrial haplogroups are not associated with preeclampsia or the severity of preeclampsia in the Danish population. However, this study cannot exclude a role for less common mtDNA variation. Models that can examine these should be applied in preeclamptic patients.
Original language | English |
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Journal | Pregnancy Hypertension |
Volume | 34 |
Pages (from-to) | 146-151 |
Number of pages | 6 |
ISSN | 2210-7789 |
DOIs | |
Publication status | Published - 2023 |
Bibliographical note
Publisher Copyright:
© 2023 The Authors
- Mitochondrial DNA, Mitochondrial haplogroups, Preeclampsia, Pregnancy
Research areas
ID: 374404566