The selective 5-HT2A receptor agonist 25CN-NBOH does not affect reversal learning in mice
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The selective 5-HT2A receptor agonist 25CN-NBOH does not affect reversal learning in mice. / Odland, Anna U.; Kristensen, Jesper L.; Andreasen, Jesper T.
In: Behavioural Pharmacology, Vol. 32, No. 5, 2021, p. 448-452.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The selective 5-HT2A receptor agonist 25CN-NBOH does not affect reversal learning in mice
AU - Odland, Anna U.
AU - Kristensen, Jesper L.
AU - Andreasen, Jesper T.
PY - 2021
Y1 - 2021
N2 - Psychedelic 5-hydroxytryptamine 2A receptor (5-HT2AR) agonists are showing promise in the treatment of psychiatric disorders, such as treatment-resistant depression and anxiety. Human studies suggest that enhanced cognitive flexibility may contribute to their clinical efficacy. Both improvement and impairment of cognitive flexibility has been reported with 5-HT2AR ligands, making the link between 5-HT2AR pharmacology and cognitive flexibility equivocal. We tested the selective 5-HT2AR agonist 25CN-NBOH in healthy male C57BL/6JOlaHsd mice in a touchscreen-based mouse reversal learning test. No effects were observed on acquisition of the new stimulus-reward contingency, learning errors, or perseverative responses during reversal. Our results suggest that 25CN-NBOH does not affect reversal learning in the schedule used in this study.
AB - Psychedelic 5-hydroxytryptamine 2A receptor (5-HT2AR) agonists are showing promise in the treatment of psychiatric disorders, such as treatment-resistant depression and anxiety. Human studies suggest that enhanced cognitive flexibility may contribute to their clinical efficacy. Both improvement and impairment of cognitive flexibility has been reported with 5-HT2AR ligands, making the link between 5-HT2AR pharmacology and cognitive flexibility equivocal. We tested the selective 5-HT2AR agonist 25CN-NBOH in healthy male C57BL/6JOlaHsd mice in a touchscreen-based mouse reversal learning test. No effects were observed on acquisition of the new stimulus-reward contingency, learning errors, or perseverative responses during reversal. Our results suggest that 25CN-NBOH does not affect reversal learning in the schedule used in this study.
KW - 25CN-NBOH
KW - cognitive flexibility
KW - 5-HT2A receptor
KW - psychedelic
KW - reversal learning
KW - serotonin
U2 - 10.1097/FBP.0000000000000626
DO - 10.1097/FBP.0000000000000626
M3 - Journal article
C2 - 33595957
VL - 32
SP - 448
EP - 452
JO - Behavioural Pharmacology
JF - Behavioural Pharmacology
SN - 0955-8810
IS - 5
ER -
ID: 275429179