The Role of CTLA-4 in T Cell Exhaustion in Chronic Hepatitis B Virus Infection
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The Role of CTLA-4 in T Cell Exhaustion in Chronic Hepatitis B Virus Infection. / Apol, Ása Didriksen; Winckelmann, Anni Assing; Duus, Rasmus Bülow; Bukh, Jens; Weis, Nina.
In: Viruses, Vol. 15, No. 5, 1141, 2023.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - The Role of CTLA-4 in T Cell Exhaustion in Chronic Hepatitis B Virus Infection
AU - Apol, Ása Didriksen
AU - Winckelmann, Anni Assing
AU - Duus, Rasmus Bülow
AU - Bukh, Jens
AU - Weis, Nina
N1 - Publisher Copyright: © 2023 by the authors.
PY - 2023
Y1 - 2023
N2 - Patients with chronic hepatitis B (CHB) gradually develop T cell exhaustion, and the inhibitory receptor molecule, cytotoxic T-lymphocyte antigen-4 (CTLA-4), may play a role in this phenomenon. This systematic review investigates the role of CTLA-4 in the development of T cell exhaustion in CHB. A systematic literature search was conducted on PubMed and Embase on 31 March 2023 to identify relevant studies. Fifteen studies were included in this review. A majority of the studies investigating CD8+ T cells demonstrated increased expression of CTLA-4 in CHB patients, though one study found this only in HBeAg-positive patients. Three out of four studies investigating the expression of CTLA-4 on CD4+ T cells found upregulation of CTLA-4. Several studies showed constitutive expression of CLTA-4 on CD4+ regulatory T cells. CTLA-4 blockade resulted in heterogeneous responses for all T cell types, as it resulted in increased T cell proliferation and/or cytokine production in some studies, while other studies found this only when combining blockade of CTLA-4 with other inhibitory receptors. Although mounting evidence supports a role of CTLA-4 in T cell exhaustion, there is still insufficient documentation to describe the expression and exact role of CTLA-4 in T cell exhaustion in CHB.
AB - Patients with chronic hepatitis B (CHB) gradually develop T cell exhaustion, and the inhibitory receptor molecule, cytotoxic T-lymphocyte antigen-4 (CTLA-4), may play a role in this phenomenon. This systematic review investigates the role of CTLA-4 in the development of T cell exhaustion in CHB. A systematic literature search was conducted on PubMed and Embase on 31 March 2023 to identify relevant studies. Fifteen studies were included in this review. A majority of the studies investigating CD8+ T cells demonstrated increased expression of CTLA-4 in CHB patients, though one study found this only in HBeAg-positive patients. Three out of four studies investigating the expression of CTLA-4 on CD4+ T cells found upregulation of CTLA-4. Several studies showed constitutive expression of CLTA-4 on CD4+ regulatory T cells. CTLA-4 blockade resulted in heterogeneous responses for all T cell types, as it resulted in increased T cell proliferation and/or cytokine production in some studies, while other studies found this only when combining blockade of CTLA-4 with other inhibitory receptors. Although mounting evidence supports a role of CTLA-4 in T cell exhaustion, there is still insufficient documentation to describe the expression and exact role of CTLA-4 in T cell exhaustion in CHB.
KW - chronic hepatitis B
KW - CTLA-4
KW - immune checkpoint inhibitors
KW - T cell exhaustion
U2 - 10.3390/v15051141
DO - 10.3390/v15051141
M3 - Review
C2 - 37243227
AN - SCOPUS:85160638157
VL - 15
JO - Viruses
JF - Viruses
SN - 1999-4915
IS - 5
M1 - 1141
ER -
ID: 356559065