The Role of a Colon-in-Continuity in Short Bowel Syndrome
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The Role of a Colon-in-Continuity in Short Bowel Syndrome. / Verbiest, Astrid; Jeppesen, Palle Bekker; Joly, Francisca; Vanuytsel, Tim.
In: Nutrients, Vol. 15, No. 3, 628, 2023.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - The Role of a Colon-in-Continuity in Short Bowel Syndrome
AU - Verbiest, Astrid
AU - Jeppesen, Palle Bekker
AU - Joly, Francisca
AU - Vanuytsel, Tim
N1 - Publisher Copyright: © 2023 by the authors.
PY - 2023
Y1 - 2023
N2 - Short bowel syndrome (SBS) is a rare gastrointestinal condition that is defined as having less than 200 cm of remaining small intestine. SBS results from extensive surgical resection and is associated with a high risk for intestinal failure (IF) with a need for parenteral support (PS). Depending on the region of intestinal resection, three different main anatomy types can be distinguished from each other. In this review, we synthesize the current knowledge on the role of the colon in the setting of SBS-IF with a colon-in-continuity (SBS-IF-CiC), e.g., by enhancing the degree of intestinal adaptation, energy salvage, and the role of the microbiota. In addition, the effect of the disease-modifying treatment with glucagon-like peptide-2 (GLP-2) analogs in SBS-IF-CiC and how it differs from patients without a colon will be discussed. Overall, the findings explained in this review highlight the importance of preservation of the colon in SBS-IF.
AB - Short bowel syndrome (SBS) is a rare gastrointestinal condition that is defined as having less than 200 cm of remaining small intestine. SBS results from extensive surgical resection and is associated with a high risk for intestinal failure (IF) with a need for parenteral support (PS). Depending on the region of intestinal resection, three different main anatomy types can be distinguished from each other. In this review, we synthesize the current knowledge on the role of the colon in the setting of SBS-IF with a colon-in-continuity (SBS-IF-CiC), e.g., by enhancing the degree of intestinal adaptation, energy salvage, and the role of the microbiota. In addition, the effect of the disease-modifying treatment with glucagon-like peptide-2 (GLP-2) analogs in SBS-IF-CiC and how it differs from patients without a colon will be discussed. Overall, the findings explained in this review highlight the importance of preservation of the colon in SBS-IF.
KW - colon-in-continuity
KW - glucagon-like peptide-2 analogs
KW - intestinal adaptation
KW - intestinal failure
KW - parenteral support
KW - short bowel syndrome
U2 - 10.3390/nu15030628
DO - 10.3390/nu15030628
M3 - Review
C2 - 36771335
AN - SCOPUS:85147802754
VL - 15
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 3
M1 - 628
ER -
ID: 367837289