The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages

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The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages. / Yang, Yunlong; Andersson, Patrik; Hosaka, Kayoko; Zhang, Yin; Cao, Renhai; Iwamoto, Hideki; Yang, Xiaojuan; Nakamura, Masaki; Wang, Jian; Zhuang, Rujie; Morikawa, Hiromasa; Xue, Yuan; Braun, Harald; Beyaert, Rudi; Samani, Nilesh; Nakae, Susumu; Hams, Emily; Dissing, Steen; Fallon, Padraic G; Langer, Robert; Cao, Yihai.

In: Nature Communications, Vol. 7, 2016, p. 11385.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Yang, Y, Andersson, P, Hosaka, K, Zhang, Y, Cao, R, Iwamoto, H, Yang, X, Nakamura, M, Wang, J, Zhuang, R, Morikawa, H, Xue, Y, Braun, H, Beyaert, R, Samani, N, Nakae, S, Hams, E, Dissing, S, Fallon, PG, Langer, R & Cao, Y 2016, 'The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages', Nature Communications, vol. 7, pp. 11385. https://doi.org/10.1038/ncomms11385

APA

Yang, Y., Andersson, P., Hosaka, K., Zhang, Y., Cao, R., Iwamoto, H., Yang, X., Nakamura, M., Wang, J., Zhuang, R., Morikawa, H., Xue, Y., Braun, H., Beyaert, R., Samani, N., Nakae, S., Hams, E., Dissing, S., Fallon, P. G., ... Cao, Y. (2016). The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages. Nature Communications, 7, 11385. https://doi.org/10.1038/ncomms11385

Vancouver

Yang Y, Andersson P, Hosaka K, Zhang Y, Cao R, Iwamoto H et al. The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages. Nature Communications. 2016;7:11385. https://doi.org/10.1038/ncomms11385

Author

Yang, Yunlong ; Andersson, Patrik ; Hosaka, Kayoko ; Zhang, Yin ; Cao, Renhai ; Iwamoto, Hideki ; Yang, Xiaojuan ; Nakamura, Masaki ; Wang, Jian ; Zhuang, Rujie ; Morikawa, Hiromasa ; Xue, Yuan ; Braun, Harald ; Beyaert, Rudi ; Samani, Nilesh ; Nakae, Susumu ; Hams, Emily ; Dissing, Steen ; Fallon, Padraic G ; Langer, Robert ; Cao, Yihai. / The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages. In: Nature Communications. 2016 ; Vol. 7. pp. 11385.

Bibtex

@article{08ce3e6922314e42b19aed7727ed8b2a,
title = "The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages",
abstract = "Signalling molecules and pathways that mediate crosstalk between various tumour cellular compartments in cancer metastasis remain largely unknown. We report a mechanism of the interaction between perivascular cells and tumour-associated macrophages (TAMs) in promoting metastasis through the IL-33-ST2-dependent pathway in xenograft mouse models of cancer. IL-33 is the highest upregulated gene through activation of SOX7 transcription factor in PDGF-BB-stimulated pericytes. Gain- and loss-of-function experiments validate that IL-33 promotes metastasis through recruitment of TAMs. Pharmacological inhibition of the IL-33-ST2 signalling by a soluble ST2 significantly inhibits TAMs and metastasis. Genetic deletion of host IL-33 in mice also blocks PDGF-BB-induced TAM recruitment and metastasis. These findings shed light on the role of tumour stroma in promoting metastasis and have therapeutic implications for cancer therapy.",
author = "Yunlong Yang and Patrik Andersson and Kayoko Hosaka and Yin Zhang and Renhai Cao and Hideki Iwamoto and Xiaojuan Yang and Masaki Nakamura and Jian Wang and Rujie Zhuang and Hiromasa Morikawa and Yuan Xue and Harald Braun and Rudi Beyaert and Nilesh Samani and Susumu Nakae and Emily Hams and Steen Dissing and Fallon, {Padraic G} and Robert Langer and Yihai Cao",
year = "2016",
doi = "10.1038/ncomms11385",
language = "English",
volume = "7",
pages = "11385",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages

AU - Yang, Yunlong

AU - Andersson, Patrik

AU - Hosaka, Kayoko

AU - Zhang, Yin

AU - Cao, Renhai

AU - Iwamoto, Hideki

AU - Yang, Xiaojuan

AU - Nakamura, Masaki

AU - Wang, Jian

AU - Zhuang, Rujie

AU - Morikawa, Hiromasa

AU - Xue, Yuan

AU - Braun, Harald

AU - Beyaert, Rudi

AU - Samani, Nilesh

AU - Nakae, Susumu

AU - Hams, Emily

AU - Dissing, Steen

AU - Fallon, Padraic G

AU - Langer, Robert

AU - Cao, Yihai

PY - 2016

Y1 - 2016

N2 - Signalling molecules and pathways that mediate crosstalk between various tumour cellular compartments in cancer metastasis remain largely unknown. We report a mechanism of the interaction between perivascular cells and tumour-associated macrophages (TAMs) in promoting metastasis through the IL-33-ST2-dependent pathway in xenograft mouse models of cancer. IL-33 is the highest upregulated gene through activation of SOX7 transcription factor in PDGF-BB-stimulated pericytes. Gain- and loss-of-function experiments validate that IL-33 promotes metastasis through recruitment of TAMs. Pharmacological inhibition of the IL-33-ST2 signalling by a soluble ST2 significantly inhibits TAMs and metastasis. Genetic deletion of host IL-33 in mice also blocks PDGF-BB-induced TAM recruitment and metastasis. These findings shed light on the role of tumour stroma in promoting metastasis and have therapeutic implications for cancer therapy.

AB - Signalling molecules and pathways that mediate crosstalk between various tumour cellular compartments in cancer metastasis remain largely unknown. We report a mechanism of the interaction between perivascular cells and tumour-associated macrophages (TAMs) in promoting metastasis through the IL-33-ST2-dependent pathway in xenograft mouse models of cancer. IL-33 is the highest upregulated gene through activation of SOX7 transcription factor in PDGF-BB-stimulated pericytes. Gain- and loss-of-function experiments validate that IL-33 promotes metastasis through recruitment of TAMs. Pharmacological inhibition of the IL-33-ST2 signalling by a soluble ST2 significantly inhibits TAMs and metastasis. Genetic deletion of host IL-33 in mice also blocks PDGF-BB-induced TAM recruitment and metastasis. These findings shed light on the role of tumour stroma in promoting metastasis and have therapeutic implications for cancer therapy.

U2 - 10.1038/ncomms11385

DO - 10.1038/ncomms11385

M3 - Journal article

C2 - 27150562

VL - 7

SP - 11385

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

ER -

ID: 166269740