The pathophysiology of osteoporosis in obesity and type 2 diabetes in aging women and men: The mechanisms and roles of increased bone marrow adiposity
Research output: Contribution to journal › Review › Research › peer-review
Standard
The pathophysiology of osteoporosis in obesity and type 2 diabetes in aging women and men : The mechanisms and roles of increased bone marrow adiposity. / Ali, Dalia; Tencerova, Michaela; Figeac, Florence; Kassem, Moustapha; Jafari, Abbas.
In: Frontiers in Endocrinology, Vol. 13, 981487, 2022.Research output: Contribution to journal › Review › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - The pathophysiology of osteoporosis in obesity and type 2 diabetes in aging women and men
T2 - The mechanisms and roles of increased bone marrow adiposity
AU - Ali, Dalia
AU - Tencerova, Michaela
AU - Figeac, Florence
AU - Kassem, Moustapha
AU - Jafari, Abbas
N1 - Publisher Copyright: Copyright © 2022 Ali, Tencerova, Figeac, Kassem and Jafari.
PY - 2022
Y1 - 2022
N2 - Osteoporosis is defined as a systemic skeletal disease characterized by decreased bone mass and micro-architectural deterioration leading to increased fracture risk. Osteoporosis incidence increases with age in both post-menopausal women and aging men. Among other important contributing factors to bone fragility observed in osteoporosis, that also affect the elderly population, are metabolic disturbances observed in obesity and Type 2 Diabetes (T2D). These metabolic complications are associated with impaired bone homeostasis and a higher fracture risk. Expansion of the Bone Marrow Adipose Tissue (BMAT), at the expense of decreased bone formation, is thought to be one of the key pathogenic mechanisms underlying osteoporosis and bone fragility in obesity and T2D. Our review provides a summary of mechanisms behind increased Bone Marrow Adiposity (BMA) during aging and highlights the pre-clinical and clinical studies connecting obesity and T2D, to BMA and bone fragility in aging osteoporotic women and men.
AB - Osteoporosis is defined as a systemic skeletal disease characterized by decreased bone mass and micro-architectural deterioration leading to increased fracture risk. Osteoporosis incidence increases with age in both post-menopausal women and aging men. Among other important contributing factors to bone fragility observed in osteoporosis, that also affect the elderly population, are metabolic disturbances observed in obesity and Type 2 Diabetes (T2D). These metabolic complications are associated with impaired bone homeostasis and a higher fracture risk. Expansion of the Bone Marrow Adipose Tissue (BMAT), at the expense of decreased bone formation, is thought to be one of the key pathogenic mechanisms underlying osteoporosis and bone fragility in obesity and T2D. Our review provides a summary of mechanisms behind increased Bone Marrow Adiposity (BMA) during aging and highlights the pre-clinical and clinical studies connecting obesity and T2D, to BMA and bone fragility in aging osteoporotic women and men.
KW - aging
KW - bone fragility
KW - bone marrow adiposity
KW - obesity
KW - osteoporosis
KW - type 2 diabetes (T2D)
U2 - 10.3389/fendo.2022.981487
DO - 10.3389/fendo.2022.981487
M3 - Review
C2 - 36187112
AN - SCOPUS:85139015283
VL - 13
JO - Frontiers in Endocrinology
JF - Frontiers in Endocrinology
SN - 1664-2392
M1 - 981487
ER -
ID: 323839727