The KCNQ1 potassium channel: from gene to physiological function.
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The KCNQ1 potassium channel: from gene to physiological function. / Jespersen, Thomas; Grunnet, Morten; Olesen, Søren-Peter.
In: Physiology, Vol. 20, 2005, p. 408-16.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The KCNQ1 potassium channel: from gene to physiological function.
AU - Jespersen, Thomas
AU - Grunnet, Morten
AU - Olesen, Søren-Peter
N1 - Keywords: Animals; Electrophysiology; Epithelium; Heart; Humans; KCNQ1 Potassium Channel
PY - 2005
Y1 - 2005
N2 - The voltage-gated KCNQ1 (KvLQT1, Kv7.1) potassium channel plays a crucial role in shaping the cardiac action potential as well as in controlling the water and salt homeostasis in several epithelial tissues. KCNQ1 channels in these tissues are tightly regulated by auxiliary proteins and accessory factors, capable of modulating the properties of the channel complexes. This paper reviews the current knowledge about the KCNQ1 channel with a major focus on interacting proteins and physiological functions.
AB - The voltage-gated KCNQ1 (KvLQT1, Kv7.1) potassium channel plays a crucial role in shaping the cardiac action potential as well as in controlling the water and salt homeostasis in several epithelial tissues. KCNQ1 channels in these tissues are tightly regulated by auxiliary proteins and accessory factors, capable of modulating the properties of the channel complexes. This paper reviews the current knowledge about the KCNQ1 channel with a major focus on interacting proteins and physiological functions.
U2 - 10.1152/physiol.00031.2005
DO - 10.1152/physiol.00031.2005
M3 - Journal article
C2 - 16287990
VL - 20
SP - 408
EP - 416
JO - Physiology
JF - Physiology
SN - 1548-9213
ER -
ID: 8418747