The interplay between trehalose and dextran as spray drying precursors for cationic liposomes
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The interplay between trehalose and dextran as spray drying precursors for cationic liposomes. / Lutta, Anitta; Knopp, Matthias M.; Tollemeto, Matteo; Pedersen, Gabriel K.; Schmidt, Signe T.; Grohganz, Holger; Hagner Nielsen, Line.
In: International Journal of Pharmaceutics, Vol. 652, 123798, 2024.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The interplay between trehalose and dextran as spray drying precursors for cationic liposomes
AU - Lutta, Anitta
AU - Knopp, Matthias M.
AU - Tollemeto, Matteo
AU - Pedersen, Gabriel K.
AU - Schmidt, Signe T.
AU - Grohganz, Holger
AU - Hagner Nielsen, Line
N1 - Publisher Copyright: © 2024 The Authors
PY - 2024
Y1 - 2024
N2 - Successful oral delivery of liposomes requires formulations designed to withstand harsh gastrointestinal conditions, e.g., by converting to solid-state followed by loading into gastro-resistant delivery devices. The hypothesis was that the use of dextran-trehalose mixtures for spray drying would improve the rehydration kinetics of dried liposomes. The objectives were to determine the protective capacity of trehalose-dextran dehydration precursors and to increase the concentration of liposomes in the dry formulation volume. The study successfully demonstrated that 8.5% dextran combined with 76.5% trehalose protected CAF®04 liposomes during drying, with the liposome content maintained at 15% of the dry powder. Accordingly, the rehydration kinetics were slightly improved in formulations containing up to 8.5% dextran in the dry powder volume. Additionally, a 2.4-fold increase in lipid concentration (3 mM vs 7.245 mM) was achieved for spray dried CAF®04 liposomes. Ultimately, this study demonstrates the significance of trehalose as a primary carrier during spray drying of CAF®04 liposomes and highlights the advantage of incorporating small amounts of dextran to tune rehydration kinetics of spray-dried liposomes.
AB - Successful oral delivery of liposomes requires formulations designed to withstand harsh gastrointestinal conditions, e.g., by converting to solid-state followed by loading into gastro-resistant delivery devices. The hypothesis was that the use of dextran-trehalose mixtures for spray drying would improve the rehydration kinetics of dried liposomes. The objectives were to determine the protective capacity of trehalose-dextran dehydration precursors and to increase the concentration of liposomes in the dry formulation volume. The study successfully demonstrated that 8.5% dextran combined with 76.5% trehalose protected CAF®04 liposomes during drying, with the liposome content maintained at 15% of the dry powder. Accordingly, the rehydration kinetics were slightly improved in formulations containing up to 8.5% dextran in the dry powder volume. Additionally, a 2.4-fold increase in lipid concentration (3 mM vs 7.245 mM) was achieved for spray dried CAF®04 liposomes. Ultimately, this study demonstrates the significance of trehalose as a primary carrier during spray drying of CAF®04 liposomes and highlights the advantage of incorporating small amounts of dextran to tune rehydration kinetics of spray-dried liposomes.
KW - Dextran
KW - Liposomes
KW - Rehydration kinetics
KW - Solid solubility
KW - Spray drying
KW - Trehalose
U2 - 10.1016/j.ijpharm.2024.123798
DO - 10.1016/j.ijpharm.2024.123798
M3 - Journal article
C2 - 38190949
AN - SCOPUS:85184752254
VL - 652
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
SN - 0378-5173
M1 - 123798
ER -
ID: 383088098