TY - JOUR

T1 - The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation

T2 - Thirty-eighth adult lung transplantation report — 2021; Focus on recipient characteristics

AU - Chambers, Daniel C.

AU - Perch, Michael

AU - Zuckermann, Andreas

AU - Cherikh, Wida S.

AU - Harhay, Michael O.

AU - HayesJr, Don

AU - Hsich, Eileen

AU - Khush, Kiran K.

AU - Potena, Luciano

AU - Sadavarte, Aparna

AU - Lindblad, Kelsi

AU - Singh, Tajinder P.

AU - Stehlik, Josef

AU - for the International Society for Heart and Lung Transplantation

N1 - Funding Information: Daniel C. Chambers received travel support from Astellas Pharma, Inc, and served as a consultant and speaker for Roche Ltd; Kiran K. Khush serves as a consultant and speaker for CareDx, Inc; Josef Stehlik serves as a consultant for Medtronic, receives research funding from Natera and receives funding from ISHLT; Michael Perch receives research funding from Roche, travel support from Boeringer-Ingelheim, and is a speaker for Mallinckrodt, Glaxo Smith Kline, and Astra-Zeneca; Wida S. Cherikh, Aparna Sadavarte, and Kelsi Lindblad received funding from ISHLT; Don Hayes, Jr; Michael O. Harhay; Aparna Sadavarte; Eileen Hsich; Luciano Potena; and Tajinder P. Singh do not have any relevant disclosures. Publisher Copyright: © 2021

PY - 2021/10

Y1 - 2021/10

N2 - For over 30 years, the International Society for Heart and Lung Transplantation (ISHLT) International Thoracic Organ Transplant (TTX) Registry has gathered data regarding transplant procedures, donor and recipient characteristics, and outcomes from a global community of transplant centers. Almost 70,000 adult lung transplant procedures have been reported to the Registry since its inception, each one providing an opportunity for a recipient with end-stage lung disease to regain quality of life and longevity. With each year's report, we provide more detailed analyses on a particular focus theme important to recipient outcomes. Since 2013, these have been donor and recipient age; retransplantation; early graft failure; indication for transplant; allograft ischemic time; multiorgan transplantation; and donor and recipient size matching.1-7 In response to a changing regulatory environment, the ISHLT TTX Registry is undergoing an update in data acquisition, and the patient cohort examined in this report is therefore derived from the same data source or datasets as that examined in the 2019 annual reports.2,8-10 We refer the reader to the 2019 and prior reports for a detailed description of the baseline characteristics of the cohort, and additional core analyses not directly related to the focus explored in this year's report. To complement the 2020 report which focussed on donor characteristics, the goal of this year's report was to focus entirely on changes in recipient factors over the past 3 decades and to identify important recipient characteristics and transplant processes that may influence post-transplant outcomes. Due to small numbers, heart-lung transplant recipient characteristics and transplant outcomes have not been included. This 38th annual adult lung transplant report is hence based on data submitted to the ISHLT TTX Registry on 67,493 adult recipients of deceased recipient transplants between January 1, 1992 and June 30, 2018.

AB - For over 30 years, the International Society for Heart and Lung Transplantation (ISHLT) International Thoracic Organ Transplant (TTX) Registry has gathered data regarding transplant procedures, donor and recipient characteristics, and outcomes from a global community of transplant centers. Almost 70,000 adult lung transplant procedures have been reported to the Registry since its inception, each one providing an opportunity for a recipient with end-stage lung disease to regain quality of life and longevity. With each year's report, we provide more detailed analyses on a particular focus theme important to recipient outcomes. Since 2013, these have been donor and recipient age; retransplantation; early graft failure; indication for transplant; allograft ischemic time; multiorgan transplantation; and donor and recipient size matching.1-7 In response to a changing regulatory environment, the ISHLT TTX Registry is undergoing an update in data acquisition, and the patient cohort examined in this report is therefore derived from the same data source or datasets as that examined in the 2019 annual reports.2,8-10 We refer the reader to the 2019 and prior reports for a detailed description of the baseline characteristics of the cohort, and additional core analyses not directly related to the focus explored in this year's report. To complement the 2020 report which focussed on donor characteristics, the goal of this year's report was to focus entirely on changes in recipient factors over the past 3 decades and to identify important recipient characteristics and transplant processes that may influence post-transplant outcomes. Due to small numbers, heart-lung transplant recipient characteristics and transplant outcomes have not been included. This 38th annual adult lung transplant report is hence based on data submitted to the ISHLT TTX Registry on 67,493 adult recipients of deceased recipient transplants between January 1, 1992 and June 30, 2018.

KW - lung transplantation

KW - morbidity

KW - post-transplant survival

KW - recipient characteristics

KW - registry

U2 - 10.1016/j.healun.2021.07.021

DO - 10.1016/j.healun.2021.07.021

M3 - Journal article

C2 - 34446355

AN - SCOPUS:85113370560

VL - 40

SP - 1060

EP - 1072

JO - Journal of Heart and Lung Transplantation

JF - Journal of Heart and Lung Transplantation

SN - 1053-2498

IS - 10

ER -