The CNTF-derived peptide mimetic Cintrofin attenuates spatial-learning deficits in a rat post-status epilepticus model
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The CNTF-derived peptide mimetic Cintrofin attenuates spatial-learning deficits in a rat post-status epilepticus model. / Russmann, Vera; Seeger, Natalie; Zellinger, Christina; Hadamitzky, Martin; Pankratova, Stanislava; Wendt, Hannes; Bock, Elisabeth; Berezin, Vladimir; Potschka, Heidrun.
In: Neuroscience Letters, Vol. 556, 27.11.2013, p. 170-5.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The CNTF-derived peptide mimetic Cintrofin attenuates spatial-learning deficits in a rat post-status epilepticus model
AU - Russmann, Vera
AU - Seeger, Natalie
AU - Zellinger, Christina
AU - Hadamitzky, Martin
AU - Pankratova, Stanislava
AU - Wendt, Hannes
AU - Bock, Elisabeth
AU - Berezin, Vladimir
AU - Potschka, Heidrun
N1 - Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.
PY - 2013/11/27
Y1 - 2013/11/27
N2 - Ciliary neurotrophic growth factor is considered a potential therapeutic agent for central nervous system diseases. We report first in vivo data of the ciliary neurotrophic growth factor peptide mimetic Cintrofin in a rat post-status epilepticus model. Cintrofin prevented long-term alterations in the number of doublecortin-positive neuronal progenitor cells and attenuated the persistence of basal dendrites. In contrast, Cintrofin did neither affect acute status epilepticus-associated alterations in hippocampal cell proliferation and neurogenesis nor reveal any relevant effect on seizure activity. Whereas status epilepticus caused a significant disturbance in spatial learning in reversed peptide-treated rats, the performance of Cintrofin-treated rats did not differ from controls. The study confirms that Cintrofin comprises an active sequence mimicking effects of its parent molecule. While the data argue against an antiepileptogenic effect, they indicate a putative disease-modifying impact of Cintrofin.
AB - Ciliary neurotrophic growth factor is considered a potential therapeutic agent for central nervous system diseases. We report first in vivo data of the ciliary neurotrophic growth factor peptide mimetic Cintrofin in a rat post-status epilepticus model. Cintrofin prevented long-term alterations in the number of doublecortin-positive neuronal progenitor cells and attenuated the persistence of basal dendrites. In contrast, Cintrofin did neither affect acute status epilepticus-associated alterations in hippocampal cell proliferation and neurogenesis nor reveal any relevant effect on seizure activity. Whereas status epilepticus caused a significant disturbance in spatial learning in reversed peptide-treated rats, the performance of Cintrofin-treated rats did not differ from controls. The study confirms that Cintrofin comprises an active sequence mimicking effects of its parent molecule. While the data argue against an antiepileptogenic effect, they indicate a putative disease-modifying impact of Cintrofin.
KW - Animals
KW - Ciliary Neurotrophic Factor
KW - Female
KW - Hippocampus
KW - Learning
KW - Microglia
KW - Molecular Mimicry
KW - Nerve Degeneration
KW - Neurogenesis
KW - Neurons
KW - Peptide Fragments
KW - Rats
KW - Rats, Sprague-Dawley
KW - Status Epilepticus
U2 - 10.1016/j.neulet.2013.10.003
DO - 10.1016/j.neulet.2013.10.003
M3 - Journal article
C2 - 24120433
VL - 556
SP - 170
EP - 175
JO - Neuroscience letters. Supplement
JF - Neuroscience letters. Supplement
SN - 0167-6253
ER -
ID: 118388488