The aminoterminal propeptide of type III procollagen provides new information on prognosis after acute myocardial infarction
Research output: Contribution to journal › Journal article › Research › peer-review
The aim of the study was to examine sequential changes in serum levels of the aminoterminal propeptide of type III procollagen (S-PIIINP) after acute myocardial infarction (AMI), and to assess the value of S-PIIINP as a predictor of outcome. The study group comprised 74 patients with AMI, and 24 patients in whom AMI was suspected but disproved. S-PIIINP changed characteristically after AMI, and in patients not receiving thrombolytic therapy or having cardiogenic shock, the changes correlated to peak enzyme values (r = 0.4, p < or = 0.03). S-PIIINP was higher at days 0 to 2 in nonsurviving AMI patients than in survivors (p < 0.05). With use of either the upper quartile for S-PIIINP at day 0 for nonsurviving AMI patients or the mean value of S-PIIINP in a normal population plus 2 SDs as a cutoff, the predictive value of a negative test ranged from 0.79 to 0.87 at days 0 to 2, and the predictive value of a positive test ranged from 0.39 to 0.67. Thus, S-PIIINP on admission and for the following few days after AMI is higher in patients with poor outcome.
Original language | English |
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Journal | American Journal of Cardiology |
Volume | 76 |
Issue number | 12 |
Pages (from-to) | 869-73 |
Number of pages | 5 |
ISSN | 0002-9149 |
Publication status | Published - 1 Nov 1995 |
- Adult, Aged, Aged, 80 and over, Biomarkers, Female, Humans, Male, Middle Aged, Myocardial Infarction, Peptide Fragments, Predictive Value of Tests, Procollagen, Prognosis, Journal Article, Research Support, Non-U.S. Gov't
Research areas
ID: 168532819