Targeted metabolic engineering guided by computational analysis of single-nucleotide polymorphisms (SNPs)
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Targeted metabolic engineering guided by computational analysis of single-nucleotide polymorphisms (SNPs). / Udatha, D B R K Gupta; Rasmussen, Simon; Sicheritz-Pontén, Thomas; Panagiotou, Gianni.
In: Methods in molecular biology (Clifton, N.J.), Vol. 985, 2013, p. 409-28.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Targeted metabolic engineering guided by computational analysis of single-nucleotide polymorphisms (SNPs)
AU - Udatha, D B R K Gupta
AU - Rasmussen, Simon
AU - Sicheritz-Pontén, Thomas
AU - Panagiotou, Gianni
PY - 2013
Y1 - 2013
N2 - The non-synonymous SNPs, the so-called non-silent SNPs, which are single-nucleotide variations in the coding regions that give "birth" to amino acid mutations, are often involved in the modulation of protein function. Understanding the effect of individual amino acid mutations on a protein/enzyme function or stability is useful for altering its properties for a wide variety of engineering studies. Since measuring the effects of amino acid mutations experimentally is a laborious process, a variety of computational methods have been discussed here that aid to extract direct genotype to phenotype information.
AB - The non-synonymous SNPs, the so-called non-silent SNPs, which are single-nucleotide variations in the coding regions that give "birth" to amino acid mutations, are often involved in the modulation of protein function. Understanding the effect of individual amino acid mutations on a protein/enzyme function or stability is useful for altering its properties for a wide variety of engineering studies. Since measuring the effects of amino acid mutations experimentally is a laborious process, a variety of computational methods have been discussed here that aid to extract direct genotype to phenotype information.
KW - Amino Acid Substitution
KW - Computational Biology
KW - Genome
KW - Genotyping Techniques
KW - Metabolic Engineering
KW - Models, Biological
KW - Polymorphism, Single Nucleotide
KW - Protein Stability
KW - Saccharomyces cerevisiae/genetics
KW - Saccharomyces cerevisiae Proteins/chemistry
KW - Sequence Alignment
KW - Sequence Analysis, DNA
U2 - 10.1007/978-1-62703-299-5_20
DO - 10.1007/978-1-62703-299-5_20
M3 - Journal article
C2 - 23417815
VL - 985
SP - 409
EP - 428
JO - Methods in Molecular Biology
JF - Methods in Molecular Biology
SN - 1064-3745
ER -
ID: 214019471